2,2’-联吡啶和三氟甲基修饰β-二酮金属钯
(Ⅱ)配合物的合成、表征和体外细胞毒性

doi:10.3969/j.issn.1000-1565.2017.02.005

河北大学学报(自然科学版) ›› 2017, Vol. 37 ›› Issue (2): 134-140.DOI: 10.3969/j.issn.1000-1565.2017.02.005

2,2’-联吡啶和三氟甲基修饰β-二酮金属钯 (Ⅱ)配合物的合成、表征和体外细胞毒性

杨亚星,段晓波,段飞,李胜辉,王书香,张金超

收稿日期:2016-08-23 出版日期:2017-03-25 发布日期:2017-03-25
通讯作者: 李胜辉(1972—),男,河北元氏人,河北大学教授,主要从事抗肿瘤药物研究.E-mail:lish@hbu.edu.cn张金超(1969—),男,河北衡水人,河北大学教授,主要从事纳米医学研究.E-mail:jczhang6970@163.com
作者简介:杨亚星(1990—),女,河北保定人,河北大学在读硕士研究生. E-mail:yangyaxingo@163.com
基金资助:
河北省自然科学基金资助项目(B2015201213);河北省应用基础研究计划重点基础研究项目(15962602D)

Synthesis,characterization and cytotoxicity of palladium(Ⅱ) complexes with β-diketonate ligands functionalized with trifluoromethyl group and 2,2’-bipyridine

YANG Yaxing,DUAN Xiaobo,DUAN Fei,LI Shenghui,WANG Shuxiang,ZHANG Jinchao

College of Chemistry and Environment Science, Hebei University, Baoding 071002, China

Received:2016-08-23 Online:2017-03-25 Published:2017-03-25

摘要/Abstract

摘要： 以取代苯乙酮、三氟乙酸乙酯及2,2’-联吡啶硝酸钯为原料,经Claisen缩合反应和螯合反应得到了系列三氟甲基修饰的β-二酮金属钯(Ⅱ)配合物.配合物结构通过了NMR、ESI-MS、IR及元素分析的表征,用X线单晶衍射测定了配合物3g的晶体结构.用MTT法对产物的体外细胞毒性进行了评价.初步结果表明:所得配合物对MCF-7细胞的毒性明显高于Hela和A549细胞,其中配合物3a对MCF-7的细胞毒性与顺铂相当.

关键词: Pd(Ⅱ)配合物, β-二酮, 三氟甲基, 联吡啶, 细胞毒性

Abstract: A novel series of palladium(Ⅱ)complexes with β-diketonate ligands functionalized with trifluoromethyl group and 2,2’-bipyridine(bipy)have been synthesized through a directed self-assembly approach that involves spontaneous deprotonation of the β-diketone ligands in H₂O/acetone solution.These complexes have been characterized by elemental analysis,IR,¹H NMR,and HRMS.Crystal structure of 3g has been determined by X-ray diffraction analysis.The cytotoxicity was tested by MTT assay.The preliminary results showed that most of the obtained complexes were more toxic against MCF-7 and Hela than A549 cells.The cytotoxicity of complexes 3a is almost equal to that of cisplatin against MCF-7.

Key words: palladium(Ⅱ)complexes, β-diketone, trifluoromethyl, bipyridine, cytotoxicity

中图分类号:

O621

杨亚星,段晓波,段飞,李胜辉,王书香,张金超. 2,2’-联吡啶和三氟甲基修饰β-二酮金属钯 (Ⅱ)配合物的合成、表征和体外细胞毒性[J]. 河北大学学报(自然科学版), 2017, 37(2): 134-140.

YANG Yaxing,DUAN Xiaobo,DUAN Fei,LI Shenghui,WANG Shuxiang,ZHANG Jinchao. Synthesis,characterization and cytotoxicity of palladium(Ⅱ) complexes with β-diketonate ligands functionalized with trifluoromethyl group and 2,2’-bipyridine[J]. Journal of Hebei University (Natural Science Edition), 2017, 37(2): 134-140.

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2,2’-联吡啶和三氟甲基修饰β-二酮金属钯 (Ⅱ)配合物的合成、表征和体外细胞毒性

Synthesis,characterization and cytotoxicity of palladium(Ⅱ) complexes with β-diketonate ligands functionalized with trifluoromethyl group and 2,2’-bipyridine

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