三维石墨烯/L-胱氨酸复合物修饰电极的制备及对氯氮平的测定

doi:10.3969/j.issn.1000-1565.2018.05.009

河北大学学报(自然科学版) ›› 2018, Vol. 38 ›› Issue (5): 503-508.DOI: 10.3969/j.issn.1000-1565.2018.05.009

三维石墨烯/L-胱氨酸复合物修饰电极的制备及对氯氮平的测定

梁宁刚,李娟娟,蔡卓,蒋翠文,叶丹妮

收稿日期:2017-11-23 出版日期:2018-09-25 发布日期:2018-09-25
通讯作者: 蔡卓(1959—),男,广东台山人,广西大学教授,主要从事电化学分析的研究工作.E-mail:zhuocai@gxu.edu.cn
作者简介:梁宁刚(1992—),男,广西上思人,广西大学硕士研究生,主要从事电化学分析的研究工作. E-mail:64289319@qq.com
基金资助:
广西自然科学基金资助项目(2015GXNSFAA139239)

Preparation of three-dimensional graphene/L-CysS composite modified electrode and its application in determination of clozapine

LIANG Ninggang, LI Juanjuan, CAI Zhuo, JIANG Cuiwen, YE Danni

School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China

Received:2017-11-23 Online:2018-09-25 Published:2018-09-25

摘要/Abstract

摘要： 采用滴涂法制备三维石墨烯/L-胱氨酸复合物修饰电极(3DGR/L-CysS/GCE),并用电化学交流阻抗谱(EIS)和扫描电镜(SEM)对电极材料进行表征.以循环伏安法(CV)、恒电位库伦分析法(CPC)、差分脉冲伏安法(DPV)和计时电量法(CC)研究了氯氮平在该修饰电极上的电化学行为.实验结果表明:在pH6.8的 Na₂HPO₄-NaH₂PO₄溶液中,氯氮平在3DGR/L-CysS/GCE上是单电子和单质子转移的电化学反应,在2.0×10^-5~5.0×10^-4 mol/L浓度内,氧化峰电流与氯氮平的线性关系良好,其检出限(S/N=3)为1.21×10^-6 mol/L.样品测定的回收率为97.5%~100.8%.

关键词: 修饰电极, L-胱氨酸, 三维石墨烯, 氯氮平

Abstract: The 3DGR/L-CysS/GCE was prepared by drop-coating method, and characterized by electrochemical impedance spectroscopy(EIS)and scanning electron microscopy(SEM). The electrochemical behaviors of clozapine at 3DGR/L-CysS/GCE were studied by cyclic voltammetry(CV), controlled potential coulometry(CPC), differential pulse voltammetry(DPV)and chronocoulometry(CC). The experimental results showed that the reaction of clozapine at 3DGR/L-CysS/GCE was an electrochemical reaction with one electron and one proton transfer. The peak current and clozapine content showed a good linear relationship in the concentration range of 2.0×10^-5~5.0×10^-4 mol/L, and the detection limit was 1.21×10^-6 mol/L(S/N=3). 3DGR/L-CysS/GCE was used for the determination of clozapine in tablets, and the recovery was 97.5%~100.8%.

Key words: modified electrode, L-cystine, three-dimensional graphene, clozapine

中图分类号:

O657.1
R914

梁宁刚,李娟娟,蔡卓,蒋翠文,叶丹妮. 三维石墨烯/L-胱氨酸复合物修饰电极的制备及对氯氮平的测定[J]. 河北大学学报(自然科学版), 2018, 38(5): 503-508.

LIANG Ninggang, LI Juanjuan, CAI Zhuo, JIANG Cuiwen, YE Danni. Preparation of three-dimensional graphene/L-CysS composite modified electrode and its application in determination of clozapine[J]. Journal of Hebei University (Natural Science Edition), 2018, 38(5): 503-508.

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三维石墨烯/L-胱氨酸复合物修饰电极的制备及对氯氮平的测定

Preparation of three-dimensional graphene/L-CysS composite modified electrode and its application in determination of clozapine

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