采用乳化溶剂蒸发法制备了油酰壳聚糖(OCS)包被的聚乙丙交酯(PLGA)纳米粒子(OCS-PL-GA NPs).采用红外光谱分析OCS-PLGA NPs.扫描电镜结果显示纳米微球形态规整、分布范围小,表面没有小孔、裂纹.PLGA浓度增大,缓释效果增强.PLGA的加入改变了疏水性内核的构造,在内核中形成网络状屏障,从而降低了药物的释放速度.OCS浓度增大,增加了纳米微球的稳定性,也增加了纳米微球外壳的厚度和致密性,增强了药物释放过程中的物理屏障,缓释效果增强.
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