研究了去除土霉素药渣中残留有效成分的方法,探讨了盐酸、氧化钙、甲醇及加热温度对去除土霉素药渣中残留有效成分的影响因素,确定了最佳条件.药渣经2.0 mol/L盐酸浸泡,95 ℃水浴加热搅拌,放置至室温,加甲醇,搅拌、抽滤,滤渣加蒸馏水混匀,用CaO调pH为5.0,95 ℃水浴搅拌,过滤,滤渣95 ℃烘干.处理后的土霉素滤渣的效价平均结果为430.0 U/g,消除率可达96.9%.

The effective method of removal the remaining active ingredient in oxytetracycline residues is studied. The influence of hydrochloride acid, calcium oxide, methanol and heating temperature on the removal of the remaining ingredient in oxytetracycline residue is investigated. In the process, the residue is firstly immersed by 2.0 mol/L HCl with mechanical stirring in a water bath of 95 ℃, and then it is cooled to room temperature accompany with adding methanol, mechanical stirring and leaching reaction solution. The filter residue is mixed by adding distilled water, adjusting the pH to 5.0 by CaO, stirring in a water bath of 95 ℃ and filtering, and then the filter residue is dried at 95 ℃. The average result of oxytetracycline residues titer after treated is 430.0 U/g and the elimination factor is 96.9%.