通过4-氯苯氧乙酸、2,4-二氯苯氧乙酸与硫氰酸钾反应合成取代苯氧异硫氰酸酯,再分别与5-氨基-1,2,3,4-四氮唑发生亲核加成反应,合成了2种未见报道的酰基硫脲衍生物.其结构经元素分析、IR和1H NMR确证,并初步测定了其生物活性.
[1] 汪焱钢, 卢冰熙, 叶文法, 赵新筠, 杨军. α-(5-四唑基)氨基烃基膦酸酯的合成及其生物活性 [J]. 有机化学 2002.doi:10.3321/j.issn:0253-2786.2002.11.008
[2] 李金昶, 王璐, 韩明友, 包明, 王广, 王元鸿, Li Jinchang, Wang Lu, Han Mingyou, BAO Ming, Wang Guang, Wang Yuanhong. 固相萃取富集高效液相色谱法测定苯氧乙酸和2, 4-二氯苯氧乙酸 [J]. 分析化学 2001.doi:10.3321/j.issn:0253-3820.2001.05.022
[3] EL- SAYED I, EL DESOKY S. Bis(methylthio)methylene malononitrile in the synthesis of heterocyclic compounds with bridgehead nitrogen [J]. Journal of Chemical Technology and Biotechnology 1996, 67.
[4] Jose L C, RICHARD G B. Controlled modification of acidity in cholecysto-kinin B receptor antagonists [J]. Journal of Medicinal Chemistry 1996, 39.
[5] 张自义, 杨虎. 酰氨基硫脲及其相关杂环衍生物研究 [J]. 有机化学 1986, 3.
[6] Brown B T, HARRIS R L N. Derivatives of 1(2' - pyridyl) thiourea as root growth inhibitors [J]. Pesticide science 1973, 4(02).
[7] MADAN V K, TANEJA A D. Preparation of spectral studies of some carboxyalkyl substuted thioureas as potential fungicides and nematicides [J]. Journal of the Indian Chemical Society 1991, 68(03).
[8] BRET E H, MICHAEL A S. A new method for the preparation of tetrazoles from nitriles using trimethsilylazied [J]. Tetrahedron Letters 1993, 34(50).
[9] 王积涛. 酰基硫脲分子内氢键与取代基效应的定量关系 [J]. 1995.
