以取代苯乙酮、三氟乙酸乙酯及2,2’-联吡啶硝酸钯为原料,经Claisen缩合反应和螯合反应得到了系列三氟甲基修饰的β-二酮金属钯(Ⅱ)配合物.配合物结构通过了NMR、ESI-MS、IR及元素分析的表征,用X线单晶衍射测定了配合物3g的晶体结构.用MTT法对产物的体外细胞毒性进行了评价.初步结果表明:所得配合物对MCF-7细胞的毒性明显高于Hela和A549细胞,其中配合物3a对MCF-7的细胞毒性与顺铂相当.
A novel series of palladium(Ⅱ)complexes with β-diketonate ligands functionalized with trifluoromethyl group and 2,2’-bipyridine(bipy)have been synthesized through a directed self-assembly approach that involves spontaneous deprotonation of the β-diketone ligands in H2O/acetone solution.These complexes have been characterized by elemental analysis,IR,1H NMR,and HRMS.Crystal structure of 3g has been determined by X-ray diffraction analysis.The cytotoxicity was tested by MTT assay.The preliminary results showed that most of the obtained complexes were more toxic against MCF-7 and Hela than A549 cells.The cytotoxicity of complexes 3a is almost equal to that of cisplatin against MCF-7.
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