采用生物可降解、无毒性的透明质酸以及右旋糖酐40等原料分别合成透明质酸酰肼(HA-NHNH2)与氧化右旋糖酐40(Odex 40),并通过氧化度测定,确定了合成Odex 40的最优方法.将上述2种物质进行反应,合成得到含腙键的透明质酸-氧化右旋糖酐嵌段聚合物(HA-Hz-Odex).通过核磁共振波谱实验表明成功合成了含腙键的嵌段聚合物HA-Hz-Odex.
Hyaluronic acid hydrazide(HA-NHNH2)and oxidized dextran 40(Odex 40)were synthesized by using biodegradable and non-toxic hyaluronic acid and dextran 40. The optimum method for the synthesis of oxidized dextran 40 was determined by oxidation degree. The above two substances were reacted with each other to obtain a hyaluronic acid-oxidized dextran block copolymer(HA-Hz-Odex)containing a hydrazine bond. The NMR study shows that the HA-Hz-Odex block copolymers containing hydrazine bonds have been successfully synthesized.
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