The construction of the quaternary carbon center has been a difficult and hot issue in organic synthesis.In particular, the synthesis of quaternary carbon center by the formation of the intermolecular C(sp3)—C(sp3)bond with cheap tert-alkyl bromides is rarely reported.Recently, our group reported that nickel-catalyzed reductive coupling of aryl bromides with tertiary alkyl halides.Based on this, we proposed that using cheap reductive metal as a free radical initiator, mediated the formation of tertiary carbon free radicals from tert-alkyl bromides, and then the free radical captured by olefin to build C(sp3)—C(sp3)bond quaternary carbon center efficiently.Herein, we report the application of this strategy in constructing quaternary carbon center by Zn powder mediated reductive coupling reaction.
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