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Influencing factors and mechanism of genetic diversity of arbuscular mycorrhizal fungi HE Xueli, QIANG Wei, ZHAO Lili Journal of Hebei University (Natural Science Edition)    2018, 38 (5): 509-516.   DOI: 10.3969/j.issn.1000-1565.2018.05.010 Abstract （1521）      PDF（pc） （1500KB）（433）       Knowledge map    Save The factors affecting the genetic diversity of AM fungi, the maintenance mechanism and the significance were summarized. This paper looks forward to the future development and application prospects of this field, in order to provide a basis for a comprehensive understanding and utilization of AM fungal genetic diversity. Reference | Related Articles | Metrics | Comments（0）

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Study on degranulation model of RBL-2H3 cells LIU Zhongcheng,LIU Shifang,LI Fei,WANG Nannan,ZHANG Nan,YUAN Xin,ZHANG Yanfen Journal of Hebei University (Natural Science Edition)    2018, 38 (2): 159-167.   DOI: 10.3969/j.issn.1000-1565.2018.02.008 Abstract （1449）      PDF（pc） （2900KB）（800）       Knowledge map    Save RBL-2H3 cells are commonly used to research on the pathogenesis of allergic diseases in vitro.In order to establish a detection model of degranulation of RBL-2H3 cells,C48/80 was used as a positive drug to analyze and compare different methods for cells degranulation detection,including the cell morphology observation,trypan blue staining,beta hexosaminidase release rate and calcium ion concentrations.Through studying the concentration and time of C48/80,the optimized drug condition was established for RBL-2H3 cell degranulation induced by C48/80.The results showed that the C48/80 concentration was 60 μg/mL with 40 min,and there was dose-effect relationship between the degree of degranulation and the beta hexosaminidase- DOI:10.3969/j.issn.1000-1565.2018.02.008RBL-2H3细胞脱颗粒模型研究刘中成1,2,刘世芳1,2,李飞1,2,王南南1,2,张楠1,2,袁欣1,2,张艳芬2,3(1.河北大学 药学院,河北 保定 071002;2.河北省药物质量分析控制重点实验室,河北 保定 071002;3.河北大学 科学技术处,河北 保定 071002)摘 要:RBL-2H3细胞是体外研究变态反应的常用细胞,为了建立RBL-2H3细胞脱颗粒检测模型,以C48/80作为阳性药物,分析比较了细胞形态观测法、台盼蓝染色法、β-氨基己糖苷酶释放率及钙离子质量浓度检测等细胞脱颗粒检测方法.通过对C48/80 作用质量浓度及时间的摸索,建立C48/80刺激RBL-2H3细胞脱颗粒的最佳药物作用条件.结果表明,β-氨基己糖苷酶释放率与细胞脱颗粒程度存在显著量-效关系,且操作简单、结果稳定.C48/80工作质量浓度为60 μg/mL,最佳作用时间40 min.在此基础上,优化了DNP-IgE/DNP-BSA诱导细胞脱颗粒体系,0.4 μg/mL DNP-IgE致敏RBL-2H3细胞过夜,10 μg/mL DNP-BSA诱导细胞,细胞脱颗粒程度最严重.同时发现,不同释放介质对DNP-BSA诱导细胞脱颗粒有显著影响.该结果可为变态反应相关研究提供实验基础.关键词:嗜碱性白血病粒细胞;脱颗粒;变态反应中图分类号:Q291 文献标志码:A 文章编号:1000-1565(2018)02-0159-09Study on degranulation model of RBL-2H3 cellsLIU Zhongcheng1,2,LIU Shifang1,2,LI Fei1,2,WANG Nannan1,2,ZHANG Nan1,2,YUAN Xin1,2,ZHANG Yanfen2,3(1.College of Pharmaceutical Sciences,Hebei University,Baoding 071002,China;2.Key Laboratory of Pharmaceutical Quality Control of Hebei Province,Baoding 071002,China;3.Office of Science and Technology,Hebei University,Baoding 071002,China)Abstract:RBL-2H3 cells are commonly used to research on the pathogenesis of allergic diseases in vitro.In order to establish a detection model of degranulation of RBL-2H3 cells,C48/80 was used as a positive drug to analyze and compare different methods for cells degranulation detection,including the cell morphology observation,trypan blue staining,beta hexosaminidase release rate and calcium ion concentrations.Through studying the concentration and time of C48/80,the optimized drug condition was established for RBL-2H3 cell degranulation induced by C48/80.The results showed that the C48/80 concentration was 60 μg/mL with 40 min,and there was dose-effect relationship between the degree of degranulation and the beta hexosaminidase- 收稿日期:2017-11-25 基金项目:国家自然科学基金资助项目(81202338);河北省自然科学基金资助项目(H2016201121);河北省高等学校科学技术研究项目(ZD2017010);国家级大学生创新创业训练计划项目(201610075007;201710075016);河北省研究生创新项目(CXZZSS2017014);河北大学实验室开放项目(sy201665) 第一作者:刘中成(1979—),男,河北抚宁人,河北大学教授,博士,主要从事分子药理学研究.E-mail:liuzc@hbu.edu.cn 通信作者:张艳芬(1979—),女,河北邯郸人,河北大学副教授,主要从事微生物生化药学研究.E-mail:zhangjing@hbu.edu.cn第2期刘中成等:RBL-2H3细胞脱颗粒模型研究release rate.Furthermore,this method was simple and reliable,the beta hexosaminidase release rate was applied to detect the degranulation of cells in subsequent experiments.when the model of cell degranulation was successfully induced by DNP-IgE/DNP-BSA,0.4 μg/mL DNP-IgE sensitized RBL-2H3 cells overnight,and 10 μg/mL DNP-BSA induced cells,the cell degranulation was the most serious.The results also showed that the cell degranulation was affected significantly by different release mediums.These results will provide the experimental basis for further studying the allergic diseases. Reference | Related Articles | Metrics | Comments（0）

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Comparative evaluation of the active ingredients and pharmacological activities of ordinary P. notoginseng powder and lyophilized P. notoginseng powder ZHANG Jun, SUN Simian, ZHAO Lin, ZHOU Hang, LIN Dongju, HUO Xiaowei Journal of Hebei University (Natural Science Edition)    2020, 40 (3): 269-275.   DOI: 10.3969/j.issn.1000-1565.2020.03.007 Abstract （1391）      PDF（pc） （969KB）（101）       Knowledge map    Save To compare the active ingredients and pharmacological activities of ordinary Panax notoginseng powder and freeze-dried P. notoginseng powder. The differences of active ingredients between the ordinary and the freeze-dried P. notoginseng powder were determined by observing the particle size of ordinary powder and freeze-dried P. notoginseng powder under the microscope, visually observing the solubility of the suspension and detecting the active ingredient content by HPLC. The differences of pharmacological effects between ordinary powder and freeze-dried P. notoginseng powder were determined by capillary tube method, tail-cut method, xylene-induced ear swelling test and organ index. The results showed that these two P. notoginseng powders were different in the particle size, solubility and active ingredient content;ordinary powder had strong effect on blood coagulation and lyophilized powder exhibited anti-inflammatory effect;- DOI:10.3969/j.issn.1000-1565.2020.03.007普通和冻干三七粉的有效成分及药理作用比较张君,孙思勉,赵琳,周航,林冬菊,霍小位 (河北大学 药学院,河北省药物质量分析控制重点实验室,河北 保定 071002)摘 要:为比较普通三七Panax notoginseng粉和冻干三七粉的有效成分及药理活性,通过在显微镜下观察普通三七粉和冻干三七粉的粒径,肉眼观察其混悬液的溶解度,HPLC法检测有效成分含量来明确普通三七粉和冻干三七粉在有效成分方面的区别.通过毛细玻管法、剪尾法、二甲苯所致小鼠耳肿胀实验和器官指数等实验研究普通三七粉和冻干三七粉在药理作用方面的差异.研究结果表明:2种三七粉的粒径、溶解度、有效成分含量存在差异.普通粉高剂量组有一定的凝血作用;冻干粉高剂量组有一定的抗炎作用,2者对免疫器官均无明显影响.关键词:三七;冻干粉;普通粉;有效成分;药理作用中图分类号:R96;R917 文献标志码:A 【additional_page=282】文章编号:1000-1565(2020)03-0269-07Comparative evaluation of the active ingredients and pharmacological activities of ordinary P. notoginseng powder and lyophilized P. notoginseng powderZHANG Jun, SUN Simian, ZHAO Lin, ZHOU Hang, LIN Dongju, HUO Xiaowei(Key Laboratory of Pharmaceutical Quality Control of Hebei Province,College of Pharmaceutical Science, Hebei University, Baoding 071002, China)Abstract: To compare the active ingredients and pharmacological activities of ordinary Panax notoginseng powder and freeze-dried P. notoginseng powder. The differences of active ingredients between the ordinary and the freeze-dried P. notoginseng powder were determined by observing the particle size of ordinary powder and freeze-dried P. notoginseng powder under the microscope, visually observing the solubility of the suspension and detecting the active ingredient content by HPLC. The differences of pharmacological effects between ordinary powder and freeze-dried P. notoginseng powder were determined by capillary tube method, tail-cut method, xylene-induced ear swelling test and organ index. The results showed that these two P. notoginseng powders were different in the particle size, solubility and active ingredient content;ordinary powder had strong effect on blood coagulation and lyophilized powder exhibited anti-inflammatory effect;- 收稿日期:2019-07-20 基金项目:河北省教育厅资助项目(QN2018153);河北大学大学生创新创业训练计划项目(2018116,2018111);河北大学研究生创新项目(hbu2019ss082) 第一作者:张君(1993—),女,河北保定人,河北大学在读硕士研究生,主要从事药理学方向的研究.E-mail:zhangjun696@126.com 通信作者:霍小位(1988—),女,山东滨州人,河北大学讲师,主要从事药理学方向的研究.E-mail:huoxiaoweiforever@163.com林冬菊(1987—),女,黑龙江哈尔滨人,河北大学讲师,主要从事药物分析方向的研究.E-mail:lindo.ngju@163.com第3期张君等:普通和冻干三七粉的有效成分及药理作用比较they both had no significant effect on immune organs. Reference | Related Articles | Metrics | Comments（0）

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Determination of related substances in edoxaban tosilate hydrate by HPLC LI Zhiwei,ZHANG Renfei,LIU Yingna,YU Yeguang,XIE Yinghua,QIU Yan Journal of Hebei University (Natural Science Edition)    2017, 37 (5): 489-496.   DOI: 10.3969/j.issn.1000-1565.2017.05.008 Abstract （1180）      PDF（pc） （1149KB）（734）       Knowledge map    Save A HPLC method was established to separate edoxaban tosilate hydrate and its related substances. SunFire C8(250 mm×4.6 mm, 5 μm)column was adopted in the analysis method and its temperature was kept at 30 ℃. The mobile phase A consisted of 20 mmol/L K2HPO4(pH 4.0)-acetonitrile(90∶10, V/V)and the mobile phase of B consisted of 20 mmol/L K2HPO4(pH 4.0)-acetonitrile(30∶70, V/V). A gradient elution at flow of 1.0 mL/min was used. The detection wavelength was 290 nm and the injection volume was 10 μL. The calibration curve of all substances were linear in appropriate concentration range, and the average recovery of all compounds were among 98.0%~102.0%, RSD(n=9)values were less than 2.0%. Each impurity was separated when the parameters had small changes and the assay variation of impurities was accepted. Methodology validation results proved that the method had good selectivity, high sensitivity, high accuracy and good robustness and it can be used for quality control of edoxaban tosilate hydrate. Reference | Related Articles | Metrics | Comments（0）

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Pyrogallol autoxidation and its application to SOD activity assay JIA Hongyu, WANG Yasen, TIAN Xiaohui, ZHANG Wei, DU Jianfang, KANG Ming, LIU Jianrong Journal of Hebei University (Natural Science Edition)    2018, 38 (3): 284-290.   DOI: 10.3969/j.issn.1000-1565.2018.03.009 Abstract （1156）      PDF（pc） （3639KB）（786）       Knowledge map    Save To verify the accuracy and feasibility of the pyrogallol autoxidation, the UV-Vis absorption spectra of autoxidation products of pyrogallol were scanned systematically in Tris-HCl and phosphate buffers for optimal wavelength determination. The inhibition modes of tcv Cu,Zn-SOD and Bovine Cu,Zn-SOD to pyrogallol autoxidation were characterized in the two buffers. The autoxidation products showed a quickly increased absorption at 320 nm in 30 s, and reached to the maxima in 30 min in a solution of 0.225 mmol/L pyrogallol in 50 mmol/L Tris-HCl, pH8.2; a weak absorption at 440 nm was also observed 30 min after the reaction started; and the rate of autoxidation of pyrogallol was A320 0.139/min.The- DOI:10.3969/j.issn.1000-1565.2018.03.009邻苯三酚自氧化法在SOD活性测定中的应用贾红玉1,王亚森1,田晓辉1,张伟1,杜建芳2,康明1,刘建荣2(1. 河北大学 生命科学学院, 河北省微生物多样性研究与应用实验室,河北 保定 071002;2. 河北大学 生物技术研究中心,河北 保定 071002)摘 要:为了验证邻苯三酚自氧化法的准确性和实用性,对邻苯三酚在Tris-HCl和磷酸盐2种不同反应体系(缓冲液)中的自氧化产物进行UV-Vis吸收光谱扫描, 确定其最适吸收峰; 同时研究了tcv Cu,ZnSOD(简称tcvSOD)和Bovine Cu,Zn-SOD(简称Bovine SOD)分别在2种缓冲液中对邻苯三酚自氧化反应的抑制模式. 波长扫描显示, 终浓度为0.225 mmol/L的邻苯三酚在50 mmol/L Tris-HCl pH 8.2缓冲液中于320 nm处30 s出现明显吸收峰, 30 min吸收峰达到最高值; 30 min 后440 nm附近出现吸收峰; A320处的自氧化速率为0.139/min. 同样浓度邻苯三酚在0.2 mol/L pH8.0磷酸缓冲液中除了A320的自氧化速率稍高(A320 0.152/min)外, 其他性质与50 mmol/L Tris-HCl相同. tcvSOD和Bovine SOD在Tris-HCl缓冲液中对邻苯三酚自氧化反应的抑制作用较磷酸盐缓冲液为强.研究结果确认320 nm可作为检测邻苯三酚自氧化、SOD对其产生抑制及SOD活性间接测定的特定波长. 关键词:邻苯三酚; 自氧化; 铜锌超氧化物歧化酶(Cu,Zn-SOD); 波长扫描中图分类号:Q554 文献标志码:A 文章编号:1000-1565(2018)03-0284-07Pyrogallol autoxidation and its application to SOD activity assay JIA Hongyu1, WANG Yasen1, TIAN Xiaohui1, ZHANG Wei1, DU Jianfang2, KANG Ming1, LIU Jianrong2(1. Key Laboratory of Microbial Diversity Research and Application of Hebei Province, College of Life Sciences, Hebei University, Baoding 071002, China;2. Biotechnology Center,Hebei University, Baoding 071002, China)Abstract:To verify the accuracy and feasibility of the pyrogallol autoxidation, the UV-Vis absorption spectra of autoxidation products of pyrogallol were scanned systematically in Tris-HCl and phosphate buffers for optimal wavelength determination. The inhibition modes of tcv Cu,Zn-SOD and Bovine Cu,Zn-SOD to pyrogallol autoxidation were characterized in the two buffers. The autoxidation products showed a quickly increased absorption at 320 nm in 30 s, and reached to the maxima in 30 min in a solution of 0.225 mmol/L pyrogallol in 50 mmol/L Tris-HCl, pH8.2; a weak absorption at 440 nm was also observed 30 min after the reaction started; and the rate of autoxidation of pyrogallol was A320 0.139/min.The- 收稿日期:2017-10-25 基金项目:国家自然科学基金资助项目(31470192);河北省自然科学基金资助项目(C2016201180) 第一作者:贾红玉(1991—), 女, 河北邢台人, 河北大学在读硕士研究生. E-mail:jhy121818298@sina.com 通信作者:刘建荣(1963—), 女, 河北保定人,河北大学副研究员, 主要从事生化与分子生物学研究. E-mail:bioinfo5@hbu.edu.cn康明(1962—), 男, 河北昌黎人,河北大学教授,博士, 主要从事微生物代谢工程以及病毒宿主相互作用研究. E-mail:mingkang@hbu.edu.cn第3期贾红玉等:邻苯三酚自氧化法在SOD活性测定中的应用autoxidation mode of 0.225 mmol/L pyrogallol in 0.2 mol/L phosphate, pH8.0 was the same as that in 50 mmol/L Tris-HCl except the rate of autoxidation associated with phosphate buffer was a little higher(A320 0.152/min). Both the tcvSOD and Bovine SOD showed slightly stronger inhibition to pyrogallol autoxidation in Tris-HCl than that in phosphate buffer. It was validated that 320 nm is the optimal wavelength for measuring the rate of pyrogallol autoxidation, the inhibition of pyrogallol autoxidation, and the indirectly determination of SOD activity. Reference | Related Articles | Metrics | Comments（0）

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Synthesis and manufacture of piperazine and its N-substituted derivatives BAI Guoyi, DONG Jie Journal of Hebei University (Natural Science Edition)    2018, 38 (5): 472-479.   DOI: 10.3969/j.issn.1000-1565.2018.05.005 Abstract （1156）      PDF（pc） （1661KB）（857）       Knowledge map    Save The main synthetic route and domestic manufacture of piperazine and its major N-substituted derivatives were reviewed in this paper. Piperazine can be synthesized by using N-β-hydroxyethyl ethylenediamine, diethylenetriamine, ethylenediamine, ethanolamine and other raw materials. Among them, the route using N-hydroxyethyl ethylenediamine as the starting material is believed as the most efficient route for the synthesis of piperazine. N-substituted derivatives of piperazine can be synthesized via either piperazine and N-alkyl agents or related primary amines, ethylene oxide and ammonia. Synthesis and manufacture of piperazine and its N-substituted derivatives have broad prospects of development due to their wide application areas and huge demand. Reference | Related Articles | Metrics | Comments（0）

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Investigation of Electromagnetically Induced Transparency Journal of Hebei University (Natural Science Edition)    2004, 24 (3): 315-319.   DOI: 10.3969/j.issn.1000-1565.2004.03.023 Abstract （1134）      PDF（pc） （347KB）（943）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Recent advances in active learning algorithms YANG Wenzhu,TIAN Xiaoxiao,WANG Sile,ZHANG Xizhong Journal of Hebei University (Natural Science Edition)    2017, 37 (2): 216-224.   DOI: 10.3969/j.issn.1000-1565.2017.02.017 Abstract （1032）      PDF（pc） （5540KB）（1206）       Knowledge map    Save Active learning mainly aims at reducing the cost of manual annotation without decreasing the accuracy of the classifier.Active learning algorithm gets high quality training sample set by selecting the informative unlabeled samples which are labeled by domain experts later.The selected sample set is used to train the classifier.This improves the generalization ability of trained classifier while minimizes the cost of the labeling.Firstly,the recent advances in the three key steps in active learning algorithm was summarized,including:1)the method for constructing the initial training sample set and its improvement;2)the sample selection strategy and its improvement;3)the termination condition and its improvement.Then,the problems in active learning were analyzed and the corresponding countermeasures were presented.Finally,the future works in active learning were addressed. Reference | Related Articles | Metrics | Comments（0）

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Research on the Image Feature Extraction ZHAI Jun-hai,ZHAO Wen-xiu,WANG Xi-zhao Journal of Hebei University (Natural Science Edition)    2009, 29 (1): 106-112.   DOI: 10.3969/j.issn.1000-1565.2009.01.024 Abstract （990）      PDF（pc） （414KB）（1506）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Approximate Algorithm for the Budgeted Maximum Coverage Problem ZHANG Sheng,HE Shang-lu Journal of Hebei University (Natural Science Edition)    2008, 28 (1): 7-9,13.   DOI: 10.3969/j.issn.1000-1565.2008.01.004 Abstract （984）      PDF（pc） （184KB）（446）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Physical modeling and finite element simulation of liver biopsy based on ANSYS ZHOU Ning,YANG Fan,SHI Ya-song,CHEN Fei,WANG Guang-lei,LIU Xiu-ling Journal of Hebei University (Natural Science Edition)    2015, 35 (2): 188-192.   DOI: 10.3969/j.issn.1000-1565.2015.02.014 Abstract （974）      PDF（pc） （1122KB）（1050）       Knowledge map    Save In order to improve the?accuracy of operation process of?needle?puncture in?virtual?operation ,we complete finite element?simulation?of ?the?typical soft tissue --liver?puncture, based on the?experimental data?and result of ?puncture real?soft tissue. Because of?the diversity?of human tissue, and the complexity of?the biomechanical properties from?soft tissues, according to the comprehensive?consideration of the material and the?mechanical properties of the soft?tissue, in this paper, we abstracted the?liver parenchyma as Mooney-Rivlin?materials, combining with deformation mechanism of ?soft tissue by stress, complete contrasting between real experiment?and simulation?based on MATLAB. It can be seen in the comparison of the curve, stress-strain curve from simulation results by ANSYS is similar with the?real data. It verify ?the effectiveness and ?the feasibility for liver puncture experiment by finite element simulation. Reference | Related Articles | Metrics | Comments（0）

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Experimental study on the relationship between concrete stress and ultrasonic velocity DU Erxia, ZHANG Junhong,YAN Yujie Journal of Hebei University (Natural Science Edition)    2018, 38 (4): 356-361.   DOI: 10.3969/j.issn.1000-1565.2018.04.003 Abstract （964）      PDF（pc） （1065KB）（369）       Knowledge map    Save Based on the ultrasonic nondestructive testing method,the natural maintained pumping concrete blocks of C20 and C30 is tested.Through the test of different ages and different points, the ultrasonic velocity and working stress are obtained. Then the Origin software is used to analyze the relationship between ultrasonic velocity and the concrete working stress.The result shows that linear function is reasonable in describing the relationship of ultrasonic velocity and working stress of concrete. Then a reference can be provided in testing the working stress of in-service concrete by nondestructive testing technology. Reference | Related Articles | Metrics | Comments（0）

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Preparation, characterization, and in vitro and in vivo evaluation of acetaminophen-PEG 6000 suppositories YANG Wenzhi, ZHANG Yi,LI Kaiyue,WU Tong,LI Haiying Journal of Hebei University (Natural Science Edition)    2018, 38 (4): 368-374.   DOI: 10.3969/j.issn.1000-1565.2018.04.005 Abstract （864）      PDF（pc） （1152KB）（879）       Knowledge map    Save In this paper, acetaminophen-PEG 6000 suppositories were prepared by solid dispersion technique. The FTIR and XRD spectra confirmed that the hydrogen bonds between drugs and matrix in solid dispersion formed and ensured the drug to be dispersed in the PEG matrix with an amorphous state, which could contribute to the rapid dissolution of the drug. The release behavior of the solid dispersion was studied in vitro. The weight ratio of drug and PEG 6000(1∶7)showed the best drug release profile among the solid dispersion samples and the drug release behaviour in vitro was close to zero order equation. Therefore, the weight ratio of drug and PEG 6000(1∶7)was chosen to prepare the acetaminophen suppositories using solid dispersion technique. Moreover, the acetaminophen suppositories and intramuscular injection dosage forms were evaluated in vivo by New Zealand rabbits experiment. The time-concentration curve of acetaminophen was determined.The pharmacokinetics showed that the ρmax reached to 169.1 μg/mL at 60 min, and the curve displayed obvious peak and valley when administrated by intramuscular injection. The pharmacokinetics of the suppositories group was obtained at 90 min and ρmax was 35.4 μg/mL,the blood drug concentration was stable and maintained continued release. There was a good correlation between - DOI:10.3969/j.issn.1000-1565.2018.04.005对乙酰氨基酚栓剂的制备、表征及兔体内外评价杨文智,章一,李凯悦,吴桐,李海鹰(河北大学 药学院,河北 保定 071002)摘 要:采用固体分散体技术,制备对乙酰氨基酚-聚乙二醇-6000(PEG 6000)基质栓剂.经FTIR和XRD验证,固体分散体中药物与基质形成分子间氢键,保证药物以无定型状态分散于基质,利于药物快速溶出.体外溶出实验显示,药基比(m(对乙酰氨基酚)∶m(PEG-6000))为1∶7时,固体分散体药物溶出较优,该比例的药物体外溶出接近零级方程,故选择此投料比自制药物栓剂.选用新西兰兔,分别给予对乙酰氨基酚栓剂和注射剂,测定药-时曲线,药代动力学表明:肌注组血药质量浓度60 min达峰值,ρmax为169.1 μg/mL,血药峰谷明显;栓剂组血药质量浓度90 min时达峰值,ρmax为35.4 μg/mL,血药质量浓度平稳并在6 h内持续释放.研究表明自制药物栓剂体内外释放呈良好的相关性,即可通过药物体外释放状况预测药物的体内吸收.关键词:对乙酰氨基酚;聚乙二醇-6000;固体分散体;栓剂中图分类号:O625 文献标志码:A 文章编号:1000-1565(2018)04-0368-07Preparation, characterization, and in vitro and in vivo evaluation ofacetaminophen-PEG 6000 suppositoriesYANG Wenzhi, ZHANG Yi,LI Kaiyue,WU Tong,LI Haiying(College of Pharmacy,Hebei University,Baoding 071002,China)Abstract: In this paper, acetaminophen-PEG 6000 suppositories were prepared by solid dispersion technique. The FTIR and XRD spectra confirmed that the hydrogen bonds between drugs and matrix in solid dispersion formed and ensured the drug to be dispersed in the PEG matrix with an amorphous state, which could contribute to the rapid dissolution of the drug. The release behavior of the solid dispersion was studied in vitro. The weight ratio of drug and PEG 6000(1∶7)showed the best drug release profile among the solid dispersion samples and the drug release behaviour in vitro was close to zero order equation. Therefore, the weight ratio of drug and PEG 6000(1∶7)was chosen to prepare the acetaminophen suppositories using solid dispersion technique. Moreover, the acetaminophen suppositories and intramuscular injection dosage forms were evaluated in vivo by New Zealand rabbits experiment. The time-concentration curve of acetaminophen was determined.The pharmacokinetics showed that the ρmax reached to 169.1 μg/mL at 60 min, and the curve displayed obvious peak and valley when administrated by intramuscular injection. The pharmacokinetics of the suppositories group was obtained at 90 min and ρmax was 35.4 μg/mL,the blood drug concentration was stable and maintained continued release. There was a good correlation between - 收稿日期:2017-10-14 基金项目:河北省高等学校科学技术项目(ZD2016102);河北省自然科学基金资助项目(H2017201052,H2018201045);河北大学精品实验项目(2017-BZ-JPSY26);河北大学2016年实验室开放项目(sy201668) 第一作者:杨文智(1972—),男,内蒙古锡林浩特人,河北大学副教授,从事生物医用材料及药物缓控释制剂方面研究.E-mail:wenzhi_yang@sina.com第4期杨文智等:对乙酰氨基酚栓剂的制备、表征及兔体内外评价in vitro drug release and in vivo drug absorption using acetaminophen suppositories, and the drug release in vitro could well predict its absorption in vivo. Reference | Related Articles | Metrics | Comments（0）

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K-nearest neighbor algorithm for big data classification based on Spark and SimHash ZHAI Junhai, SHEN Chu, ZHANG Sufang, WANG Tingting Journal of Hebei University (Natural Science Edition)    2019, 39 (2): 201-210.   DOI: 10.3969/j.issn.1000-1565.2019.02.014 Abstract （860）      PDF（pc） （1190KB）（198）       Knowledge map    Save In our previous work, based on MapRecuce and SimHash, we proposed a K-Nearest Neighbor(K-NN)algorithm denoted by H-MR-K-NN for big data classification. Although H-MR-K-NN can effectively solve the computational efficiency problem of K-NN for big data classification, and the running time of H-MR-K-NN is far lower than the one of MapRecuce K-NN denoted by MR-K-NN. However, when one handles big data with MapReduce, it is inevitable to read data from disk and to write the intermediate result back to disk, which results in huge I/O overhead and greatly degenerates the efficiency of MapReduce. Different from MapReduce, Spark is a memory-based computing framework that reads data into memory from disk first and then generates an abstract memory object RDD(resilient distributed datasets). Therefore,Spark only manipulates RDD in memory, and the- DOI:10.3969/j.issn.1000-1565.2019.02.014基于Spark和SimHash的大数据K-近邻分类算法翟俊海1,沈矗1,张素芳2,王婷婷1 (1. 河北大学 数学与信息科学学院 河北省机器学习与计算智能重点实验室,河北保定 071002;2. 中国气象局气象干部培训学院 河北分院,河北 保定 071000)摘 要: 在笔者之前的工作中,提出了一种基于MapReduce和SimHash的大数据K-近邻算法(H-MR-K-NN).虽然该算法能够有效解决大数据K-近邻算法的计算效率问题,运行时间远远低于基于MapReduce的K-近邻(MR-K-NN)所用的运行时间.然而,用MapReduce处理大数据时,需要从磁盘读取数据,再将中间结果写回磁盘,导致系统的I/O开销极大,这大大降低了MapReduce的效率.与MapReduce不同,Spark是一种基于内存的计算框架,它将数据第1次从磁盘读入内存,生成一种抽象的内存对象RDD(resilient distributed datasets).此后,Spark只操作内存中的RDD,计算过程只涉及内存读写,因此大幅提升了数据处理效率.基于这一事实,对算法H-MR-K-NN进行了改进,提出了一种改进的算法(简记为H-Spark-K-NN),可以进一步提高大数据K-近邻分类的运行效率.关键词:内存计算框架;K-近邻;哈希技术;分类算法;大数据集中图分类号:TP181 文献标志码:A 文章编号:1000-1565(2019)02-0201-10K-nearest neighbor algorithm for big data classification based onSpark and SimHashZHAI Junhai1, SHEN Chu1, ZHANG Sufang2, WANG Tingting1(1. Key Laboratory of Machine Learning and Computational Intelligence of Hebei Province, College of Mathematics and Information Science, Hebei University, Baoding 071002, China; 2. Hebei Branch of ChinaMeteorological Administration Training Centre, China Meteorological Administration, Baoding 071000, China)Abstract:In our previous work, based on MapRecuce and SimHash, we proposed a K-Nearest Neighbor(K-NN)algorithm denoted by H-MR-K-NN for big data classification. Although H-MR-K-NN can effectively solve the computational efficiency problem of K-NN for big data classification, and the running time of H-MR-K-NN is far lower than the one of MapRecuce K-NN denoted by MR-K-NN. However, when one handles big data with MapReduce, it is inevitable to read data from disk and to write the intermediate result back to disk, which results in huge I/O overhead and greatly degenerates the efficiency of MapReduce. Different from MapReduce, Spark is a memory-based computing framework that reads data into memory from disk first and then generates an abstract memory object RDD(resilient distributed datasets). Therefore,Spark only manipulates RDD in memory, and the- 收稿日期:2018-10-15 基金项目:河北省自然科学基金资助项目(F2017201026);河北大学自然科学研究计划项目(799207217071);河北大学研究生创新项目(hbu2018ss47);河北省研究生专业学位教学案例库建设项目(KCJSZ2018009) 第一作者:翟俊海(1964—),男,河北易县人,河北大学教授,博士,主要从事云计算与大数据处理和机器学习方向研究.E-mail:mczjh@hbu.cn 通信作者:张素芳(1966—),女,河北蠡县人,中国气象局气象干部培训学院副教授,主要从事机器学习方向研究.E-mail:mczsf@126.com第2期翟俊海等:基于Spark和SimHash的大数据K-近邻分类算法calculation process involves only memory reads and writes. Consequently, it greatly improves efficiency of data processing. Based on this fact, we improved the algorithm H-MR-K-NN, and proposed an improved algorithm denoted shortly by H-Spark-K-NN which can further improve the efficiency of K-NN for big data classification. Reference | Related Articles | Metrics | Comments（0）

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Comparison Analysis on Ranking Consensus Li Chunguo, Li Haifeng Journal of Hebei University (Natural Science Edition)    2015, 35 (2): 182-187.   DOI: 10.3969/j.issn.1000-1565.2015.02.013 Abstract （853）      PDF（pc） （1173KB）（616）       Knowledge map    Save Unsupervised ranking has a big challenge that there is no standard metric to measure the ranking results. This paper tries to propose a comparison scheme for unsupervised ranking based on ranking consensus. Some metrics used in supervised ranking can be used here to measure unsupervised ranking consensus. However, these metrics are taken between ranking lists and attributes, rather than ranking lists and ranking labels. Experimental results on UCI datasets show that RPC, which is one kind of unsupervised ranking aggregation method, has the minimum Kendall Distance and Spearman Footrule Distance than the other representative unsupervised ranking methods. Reference | Related Articles | Metrics | Comments（0）

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Multi-generator generative adversarial networks SHEN Ruicai, ZHAI Junhai, HOU Yingzhen Journal of Hebei University(Natural Science Edition)    2021, 41 (6): 734-744.   DOI: 10.3969/j.issn.1000-1565.2021.06.014 Abstract （842）      PDF（pc） （2282KB）（272）       Knowledge map    Save Generative adversarial networks(GAN)are widely used in various fields, especially in image generation. The model consists of two parts, a generative network and a discriminative network, and the two networks compete with each other to improve each other in an unsupervised training method. However, GAN often suffers from pattern collapse during training, which leads to slow convergence of the model and poor diversity of generated samples. To solve this problem, a multi-generator generative adversarial network model based on deep convolutional neural networks is proposed. The model consists of multiple generative networks, each of which is built using residual networks, and a collaboration mechanism is introduced among the generative networks to speed up the information acquisition and reduce the number of parameters, and finally the feature maps of each generative network are fused to obtain the final image and input to the discriminative network. GAN also has the problems of gradient disappearance and training instability. To address the two problems, Wasserstein distance and gradient penalty are introduced into the loss function of the mode. Through experimental comparison with several related methods on multiple datasets, the results show that the proposed model significantly outperforms several- DOI:10.3969/j.issn.1000-1565.2021.06.014多生成器生成对抗网络申瑞彩,翟俊海,侯璎真(河北大学 数学与信息科学学院,河北省机器学习与计算智能重点实验室,河北 保定 071002)摘 要:生成对抗网络(Generative adversarial networks,GAN)广泛应用于各种领域,尤其在图像生成方面.该模型由生成网络与判别网络2部分组成,在无监督的训练方式下,2个网络相互竞争相互提高.然而,GAN在训练时经常出现模式崩溃问题,进而导致模型收敛较慢,生成样本多样性较差.为解决这一问题,在深度卷积神经网络的基础上提出了一种多生成器生成对抗网络模型.该模型包含多个生成网络,每个生成网络均使用残差网络进行搭建,同时在生成网络间引入协作机制,以加快模型获取信息并减少参数量,最后将各生成网络的特征图进行融合得到最终图像输入到判别网络中.GAN在训练过程中还会出现梯度消失、训练不稳定问题.为避免出现这些问题,将Wasserstein距离和梯度惩罚引入模型的损失函数.通过在多个数据集上与多种相关方法进行实验比较,结果表明提出的模型在缓解模式崩溃问题、加快模型收敛速度以及减少参数量上均明显优于其他几种方法.关键词:生成对抗网络;残差网络;集成学习;模式崩溃;Wasserstein距离 中图分类号:TP181 文献标志码:A 文章编号:1000-1565(2021)06-0734-11Multi-generator generative adversarial networksSHEN Ruicai, ZHAI Junhai, HOU Yingzhen(Hebei Key Laboratory of Machine Learning and Computational Intelligence, College of Mathematics and Information Science, Hebei University, Baoding 071002,China)Abstract: Generative adversarial networks(GAN)are widely used in various fields, especially in image generation. The model consists of two parts, a generative network and a discriminative network, and the two networks compete with each other to improve each other in an unsupervised training method. However, GAN often suffers from pattern collapse during training, which leads to slow convergence of the model and poor diversity of generated samples. To solve this problem, a multi-generator generative adversarial network model based on deep convolutional neural networks is proposed. The model consists of multiple generative networks, each of which is built using residual networks, and a collaboration mechanism is introduced among the generative networks to speed up the information acquisition and reduce the number of parameters, and finally the feature maps of each generative network are fused to obtain the final image and input to the discriminative network. GAN also has the problems of gradient disappearance and training instability. To address the two problems, Wasserstein distance and gradient penalty are introduced into the loss function of the mode. Through experimental comparison with several related methods on multiple datasets, the results show that the proposed model significantly outperforms several- 收稿日期:2021-05-26 基金项目:河北省科技计划重点研发计划项目(19210310D); 河北省自然科学基金资助项目(F2021201020) 第一作者:申端彩(1993—),女,河北邯郸人,河北大学在读硕士研究生,主要从事深度学习研究.E-mail:1943303808@qq.com 通信作者:翟俊海(1964—),男, 河北易县人, 河北大学教授, 博士生导师, 主要从事云计算与大数据处理和深度学习方向研究.E-mail:mczjh@hbu.cn第6期申瑞彩等:多生成器生成对抗网络other methods in alleviating the pattern collapse problem, speeding up model convergence, and reducing the number of parameters. Reference | Related Articles | Metrics | Comments（0）

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Analysis of the magnetic field distribution uniformity of two electricity circular coil axis ZHANG Fengchun,MA Quanxi Journal of Hebei University (Natural Science Edition)    2014, 34 (4): 368-371.   DOI: 10.3969/j.issn.1000-1565.2014.04.007 Abstract （841）      PDF（pc） （655KB）（621）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Effects of reactive diluents type on chemical structure and property of epoxy resin system LI Shanjian,DENG Shuanghui,FENG Yunlong,LIU Chaofan,LIU Zuozhen Journal of Hebei University (Natural Science Edition)    2016, 36 (6): 604-613.   DOI: 10.3969/j.issn.1000-1565.2016.06.007 Abstract （827）      PDF（pc） （1200KB）（646）       Knowledge map    Save The chemical reactivity and network and properties after curing of diglycidyl ether of bisphenol A(DGEBA)/amine systems were studied using viscosity analysis,different scanning calorimetry analysis(DSC),thermogravimetric analysis and universal testing machine.using three different diluents,including 1,4-butanediol diglycidyl ether,phenyl glycidyl ether and decylglycide ether.The result showed that the addition of aromatic diluents PGE into DGEBA curing system accelerated the curing reaction to a certain extent,resulted in enhancement of tensile and flexural strength and modulus,but led to a reduction of both elongation and the impact strength.However,the addition of the other two diluents had the contrary effects on these properties and the DGE which had the longest fatty chain segment had the most obvious effects.All tested modified epoxy compositions had lower thermal stability than unmodified epoxy resin.- DOI:10.3969/j.issn.1000-1565.2016.06.007活性稀释剂对环氧树脂结构和性能的影响李山剑1,邓双辉2,冯云龙2,刘超凡1,刘坐镇1,2(1.华东理工大学 材料科学与工程学院,特种功能高分子材料及相关技术教育部重点实验室,上海 200237;2.华东理工大学 华昌聚合物有限公司,上海防腐蚀新材料工程技术研究中心,上海 200237)摘 要:选用3种具有不同分子结构和官能度的缩水甘油醚——1,4-丁二醇二缩水甘油醚(BDDGE)、苯基缩水甘油醚(PGE)和癸基缩水甘油醚(DGE)作为活性稀释剂,通过黏度、DSC、热重分析和万能实验机等方法考察了其对双酚A环氧-胺固化体系的反应活性、交联网络结构和性能的影响.结果表明:芳香类稀释剂的加入,对环氧-胺固化体系的反应活性影响不大甚至有所提升,且固化物的强度和模量提高,韧性降低;而脂肪族稀释剂则明显降低了固化体系的反应活性,随着脂肪链长度的增加,固化物的强度和模量下降,韧性提高;3种稀释剂的加入均降低了环氧体系的耐热性能.关键词:环氧树脂;活性稀释剂;反应活性;交联结构;性能中图分类号:O631 文献标志码:A 文章编号:1000-1565(2016)06-0604-10Effects of reactive diluents type on chemical structure and property of epoxy resin systemLI Shanjian1,DENG Shuanghui2,FENG Yunlong2,LIU Chaofan1,LIU Zuozhen1,2(1.Key Laboratory for Special Functional Polymers and Related Technology of Ministry of Education,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237; 2.Shanghai Engineering Research Center of New Anti-corrosion Materials,Sino Polymer Co Ltd,East ChinaUniversity of Science and Technology,Shanghai 200237,China)Abstract: The chemical reactivity and network and properties after curing of diglycidyl ether of bisphenol A(DGEBA)/amine systems were studied using viscosity analysis,different scanning calorimetry analysis(DSC),thermogravimetric analysis and universal testing machine.using three different diluents,including 1,4-butanediol diglycidyl ether,phenyl glycidyl ether and decylglycide ether.The result showed that the addition of aromatic diluents PGE into DGEBA curing system accelerated the curing reaction to a certain extent,resulted in enhancement of tensile and flexural strength and modulus,but led to a reduction of both elongation and the impact strength.However,the addition of the other two diluents had the contrary effects on these properties and the DGE which had the longest fatty chain segment had the most obvious effects.All tested modified epoxy compositions had lower thermal stability than unmodified epoxy resin.- 收稿日期:2016-07-01 基金项目:上海市重大科技攻关项目(12dz1100401);上海工程技术研究中心能力提升项目(13DZ2280900) 第一作者:李山剑(1992—),男,江苏如皋人,华东理工大学在读硕士研究生.E-mail:lsj262728@126.com 通信作者:刘坐镇(1965—),男,河南新密人,华东理工大学教授,主要从事热固性树脂及其复合材料的研究.E-mail:lzz@hchp.com.cn第6期李山剑等:活性稀释剂对环氧树脂结构和性能的影响 Reference | Related Articles | Metrics | Comments（0）

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Research progress of loop-mediated isothermal amplification technology SHI Lei, WANG Man, SHI Guoqiang, DONG Zhenguo, LIU Yu Journal of Hebei University(Natural Science Edition)    2021, 41 (5): 565-571.   DOI: 10.3969/j.issn.1000-1565.2021.05.013 Abstract （815）      PDF（pc） （775KB）（312）       Knowledge map    Save Loop-mediated isothermal amplification(LAMP)is an efficient, simple, highly specific nucleic acid amplification technology without thermal cycling equipment.As LAMP still has great potential for- DOI:10.3969/j.issn.1000-1565.2021.05.013环介导等温扩增技术研究进展石磊1,王曼2,时国强3,董振国3,刘昱2(1.暨南大学 食品安全与营养研究院,广东 广州 510000;2.河北农业大学 生命科学学院,河北 保定 071003; 3. 河北三狮生物科技有限公司 研发部,河北 石家庄 050000)石磊 博士,教授,博士生导师,1985年毕业于河北大学生物系并获学士学位,现任暨南大学食品安全与营养研究院院长,河北农业大学生命科学学院特聘兼职教授;国家重大人才工程入选者,国家重点研发计划首席科学家,肉食品安全生产技术国家重点实验室主任,第一届国家食品安全标准审评委员会委员,中国食源性微生物检测技术创新战略联盟副理事长,广东省免疫学会副理事长,广州双螺旋基因技术有限公司董事长;主要从事病原微生物快速诊断方法、临床微生物耐药基因解析及耐药性基因诊断研究;在SCI收录期刊上发表论文100余篇,申请专利26项,其中发明专利25项,实用新型专利1项;先后主持“国家重点研发计划”、“国家973计划项目”、“国家海洋经济创新发展区域示范专项”等10余项国家级项目;2018年获中国人民解放军军队科技进步二等奖,2019年获第四届中国水产学会范蠡科学技术奖技术推广奖、优秀成果奖.摘 要:环介导等温扩增(loop-mediated isothermal amplification,LAMP)技术是一种高效、简便、高特异性、无需热循环设备的核酸扩增技术. 由于LAMP依然具备巨大的改造潜力,所以近些年来,一直有研究改进其技术以期达到更好的扩增检测效果. 本文对LAMP的基本原理、应用领域范围以及技术改良方向进行了综述,为今后该技术的改良与发展提供参考. 关键词:环介导等温扩增(LAMP);技术改良;发展方向中图分类号:Q7 文献标志码:A 文章编号:1000-1565(2021)05-0565-07Research progress of loop-mediated isothermal amplification technologySHI Lei1, WANG Man2, SHI Guoqiang3, DONG Zhenguo3, LIU Yu2(1. Institute of Food Safety and Nutrition,Jinan University, Guangzhou 510000, China; 2. College of Life Science, Agricultural University of Hebei, Baoding 071003, China; 3.Research and Development Department,Hebei Sanshi Biological Technology Co., LTD, Shijiazhuang 050000, China)Abstract: Loop-mediated isothermal amplification(LAMP)is an efficient, simple, highly specific nucleic acid amplification technology without thermal cycling equipment.As LAMP still has great potential for- 收稿日期:2021-06-16 基金项目:河北省创新能力提升计划项目(205A7601D);石家庄市高层次科技创新创业人才项目(05202001) 第一作者:石磊(1961—),男,河北保定人,暨南大学教授,博士生导师,主要从事病原微生物核酸分子检测等研究. E-mail:leishi88@139.com 通信作者:刘昱(1990—),男,山东临沂人,河北农业大学在读博士研究生,主要从事病原微生物核酸分子检测的研究.E-mail:1085869940@qq.com第5期石磊等:环介导等温扩增技术的研究进展modification, many studies have been conducted in recent years to improve its technology in order to achieve better amplification detection results.In this paper, the basic principle, application scope and technical improvement direction of LAMP were reviewed, to provide references for the improvement and development of LAMP technology in the future. Reference | Related Articles | Metrics | Comments（0）

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A survey on user behavior of social network based on knowledge graph YANG Xiaohui, SUN Ying Journal of Hebei University(Natural Science Edition)    2021, 41 (1): 77-86.   DOI: 10.3969/j.issn.1000-1565.2021.01.012 Abstract （807）      PDF（pc） （617KB）（479）       Knowledge map    Save Social networks contain complex structural information and rich semantic information. The research of multi-type data of interconnection and the behavioral relationship security of entity objects are facing great challenges. Knowledge graph is designed to process user data knowledge and behavior information, and to find the complex relationship between things, concepts and entity objects, so that the relationship between things can be clearly explained. Firstly, basic knowledge of knowledge graph was introduced. Secondly, based on knowledge graph, the behavioral relationship of users is visualized in the social network, and the key technologies and research progress of the three modules of behavioral knowledge extraction, behavioral knowledge expression, and behavioral knowledge processing are summarized. By experimental analysis and comparison of the technical models, the visual identification technology was introduced. By using probability soft logic to identify candidate behavioral knowledge, the accuracy of user behavior relationship visualization was improved. Finally, the application of user behavior relation visualization in user information retrieval, user security evaluation and behavior correlation analysis is introduced, the challenges of current research are discussed and analyzed, and its development is prospected. Reference | Related Articles | Metrics | Comments（0）

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Detection algorithm of tea tender buds under complex background based on deep learning SUN Xiaoxiao, MU Shaomin, XU Yongyu, CAO Zhihao, SU Tingting Journal of Hebei University (Natural Science Edition)    2019, 39 (2): 211-216.   DOI: 10.3969/j.issn.1000-1565.2019.02.015 Abstract （806）      PDF（pc） （1561KB）（352）       Knowledge map    Save The traditional tea bud detection method based on machine vision has the problems of poor robustness and low accuracy in manual feature extraction. The target detection algorithm YOLO based on deep learning is applied to the detection of tea tender image under complex background for the first time, and the architecture of YOLO network is improved from the aspect of multi-scale detection, using large-scale and mesoscale detection instead of the original multi-scale detection. In the preprocessing stage, the image of tea shoots under complex background is segmented by combining the super green feature and the OSTU algorithm, which makes the tea tender bud area more obvious. The experimental results show that, by comparing with other algorithms, the target detection algorithm based on deep learning has a high detection precision for the tea tender shoots under complex background, which provides a basis for the research of intelligent picking equipment for tea tender shoots under complex background. Reference | Related Articles | Metrics | Comments（0）

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Enhancing effect of mushroom activating enzymes on Lentinus edodes ZHANG Heying, LUO Junmian,YUAN Erying, GENG Liduo, WU Jinxia Journal of Hebei University (Natural Science Edition)    2019, 39 (2): 183-187.   DOI: 10.3969/j.issn.1000-1565.2019.02.011 Abstract （799）      PDF（pc） （1692KB）（451）       Knowledge map    Save The influence of mushroom activating enzymes on mycelium growth cycle,mycelium extracellular enzyme activity,physical and chemical indicators of cultivation material,biological efficiency and nutrient content of the Lentinus edodes fruiting body were studied during the fruiting body growth stage when 0.2% of mushroom activating enzymes were added in culture and the solid strains were inoclulated into the culture.The results showed that the time of mycelium growing full of the bags was 70 days, being shortened by 15 days compared with control.The cellulase、protease and amylase activity of mycelium in the mushroom activating enzymes group increased continuously during the colour changing period and the enzyme activities were significantly higher than that of control.After fruiting, the L. edodes fruiting body were collected and analyzed.The biological efficiency of the mushroom activating enzymes group achieved 96.75%,21.99% higher than that of control.The nutrient content was slightly higher than that of control,however,there was no significant difference between the two groups. Reference | Related Articles | Metrics | Comments（0）

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Convolutional neural network and its research advances ZHAI Junhai,ZHANG Sufang,HAO Pu Journal of Hebei University (Natural Science Edition)    2017, 37 (6): 640-651.   DOI: 10.3969/j.issn.1000-1565.2017.06.012 Abstract （796）      PDF（pc） （1277KB）（910）       Knowledge map    Save Deep learning is the most popular research topic in the field of machine learning,AlphaGo which overwhelmingly impacts the world is trained with deep learning algorithms.Convolution neural network(CNN)is a model trained with deep learning algorithm,CNN is widely and successfully applied in computer version.The main purpose of this paper includes two aspects:one is to provide readers with some insights into CNN including its architecture,related concepts,operations and its training; the other is to present a comprehensive survey on research advances of CNN,mainly focusing on 4 aspects: activation functions,pooling,training and applications of CNN.Furthermore,the emerging challenges and hot research topics of CNN are also discussed.This paper can be very helpful to researchers in related field. Reference | Related Articles | Metrics | Comments（0）

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Microwave assisted synthesis and antibacterial study of 2-aryl-1,3-benzoxathiin-4-ones FENG Junna,PENG Shaohui,CUI Penglei,CHEN Hua,LI Xiaoliu Journal of Hebei University (Natural Science Edition)    2016, 36 (4): 396-401.   DOI: 10.3969/j.issn.1000-1565.2016.04.011 Abstract （773）      PDF（pc） （983KB）（384）       Knowledge map    Save A series of 2-aryl-1,3-benzoxathiin-4-ones were synthesized by aromatic aldehyde and thiosalicylic acid under microwave irradiation for 5 min.The reaction is fast,simple and has high yield.The structures of the synthesized compounds were characterized by IR,NMR,MS spectra and elemental analysis.Antibacterial(Escherichia coli and Dysentery bacillus)activities of the compounds against Escherichia coli and Dysentery bacillus were evaluated.The results showed that 2-aryl-1,3-benzoxathiin-4-ones had good antibacterial activity. Reference | Related Articles | Metrics | Comments（0）

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On Some Centipede Species of the Genus Otostigmus From China (Scolopendromorpha: Scolopendridae) SONG Zhi-shun,GAl Yong-hua,SONG Da-xiang,ZHU Ming-sheng Journal of Hebei University (Natural Science Edition)    2005, 25 (3): 295-304.   DOI: 10.3969/j.issn.1000-1565.2005.03.016 Abstract （771）      PDF（pc） （693KB）（409）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Analysis of spatiotemporal changes of vegetation net primary productivity and correlation between NPP and climate factors in Hebei province from 2001 to 2010 ZHANG Sha,YUAN Jinguo,ZHANG Yujia,WU Xifang Journal of Hebei University (Natural Science Edition)    2014, 34 (5): 516-523.   DOI: 10.3969/j.issn.1000-1565.2014.05.013 Abstract （770）      PDF（pc） （1337KB）（505）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Progress in phenol hydrogenation WEN Xin, DONG Jie, SHE Tiantian, BAI Guoyi Journal of Hebei University (Natural Science Edition)    2018, 38 (3): 239-247.   DOI: 10.3969/j.issn.1000-1565.2018.03.003 Abstract （769）      PDF（pc） （1754KB）（530）       Knowledge map    Save Cyclohexanol and cyclohexanone are important chemical raw materials, which are the key intermediates in the manufacture of nylon 6 and nylon 66. The hydrogenation of phenol to cyclohexanol or cyclohexanone has attracted much attention due to its low energy consumption, good atom economy and good selectivity. In this review, the hydrogenation mechanism of phenol is introduced, and the different kinds of metal catalysts in the hydrogenation of phenol are reviewed. Finally, the problems and development strategies in phenol hydrogenation are also discussed. Reference | Related Articles | Metrics | Comments（0）

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Fabrication of hollow porous carbon nanofibers by coaxial electrospinning YANG Zelin,ZHENG Haoran,ZHI Shenghui,YANG Yanxing,ZHANG Wenming Journal of Hebei University (Natural Science Edition)    2016, 36 (3): 237-241.   DOI: 10.3969/j.issn.1000-1565.2016.03.004 Abstract （757）      PDF（pc） （290KB）（530）       Knowledge map    Save Core/shell polyacrylonitrile(PAN)fibers were prepared by coaxial electrospinning using PMMA solution as the core,PAN solution as the shell,ZnO as the pore former.After calcination and acid treatment,the hollow porous carbon nanofibers were obtained.Morphologies of the fibers were characterized by transmission electron microscope(TEM); and the effect of solution concentration,voltage and flow rates on core and shell diameters were also investigated.The results showed that the optimized condition for the satisfactory hollow porous carbon nanofibers was 10% PMMA,10% PAN,6% zinc acetate,15 kV,1.0 mL/h inner rate and 1.5 mL/h outer rates. Reference | Related Articles | Metrics | Comments（0）

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Influencing Factors of the Crystal Growth Under Hydrothermal Condition Journal of Hebei University (Natural Science Edition)    2002, 22 (4): 345-350.   DOI: 10.3969/j.issn.1000-1565.2002.04.009 Abstract （757）      PDF（pc） （250KB）（1404）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Effects of crosslinking point functionality and network entanglement on buckling instability of hydrogel films LI Tao, YANG Qingsheng Journal of Hebei University(Natural Science Edition)    2020, 40 (6): 591-596.   DOI: 10.3969/j.issn.1000-1565.2020.06.005 Abstract （754）            Knowledge map    Save The research on the buckling instability of hydrogel films has been the focus of the application of hydrogel films. In this paper, effects of topological network structure of hydrogels and network entanglement effect of polymer network that constitutes hydrogels on large coupling deformation of hydrogels are taken into account. A free energy equation combining the slip-link model proposed by Edwards-Vilgis with Flory-Huggins theory is introduced to demonstrate the real influence of polymer network on large deformation of hydrogels in the chemo-mechanical coupling field. The critical stress and wavelength of unidirectional nonlinear buckling of two-dimensional hydrogel films were solved by analytical method, and the influence of the microstructure of polymer network that constitutes hydrogels on the buckling of hydrogel films under different external solution environment conditions was discussed.- DOI:10.3969/j.issn.1000-1565.2020.06.005交联点官能度和网络缠结效应对凝胶薄膜屈曲失稳的影响李涛,杨庆生(北京工业大学 机械工程与应用电子技术学院,北京 100124)摘 要:对于响应型水凝胶薄膜屈曲失稳行为的研究一直是水凝胶薄膜应用中的重点.本文考虑水凝胶拓扑网络结构以及构成水凝胶的高分子网络缠结效应凝胶耦合大变形中的影响,引入了一种将Edwards-Vilgis的slip-link模型与Flory-Huggins理论相结合的自由能方程,旨在还原水凝胶在化学-力学耦合场作用下发生大变形时真实高分子网络的作用.通过解析方法求解了二维水凝胶薄膜单向非线性屈曲的临界应力和波长,探讨了外部溶液环境变化时,构成水凝胶的高分子网络微结构对凝胶薄膜屈曲的影响.结果表明:水凝胶的微结构参数在较小数值变化时对水凝胶增量模量以及凝胶薄膜屈曲的临界应力和波长有显著影响,当微结构参数不断变大这种影响逐渐减弱.关键词:水凝胶薄膜;屈曲;化学-力学耦合;解析解中图分类号:O345 文献标志码:A 文章编号:1000-1565(2020)06-0591-06Effects of crosslinking point functionality and network entanglement on buckling instability of hydrogel filmsLI Tao, YANG Qingsheng(College of Engineering Mechanics, Beijing University of Technology, Beijing 100124, China)Abstract: The research on the buckling instability of hydrogel films has been the focus of the application of hydrogel films. In this paper, effects of topological network structure of hydrogels and network entanglement effect of polymer network that constitutes hydrogels on large coupling deformation of hydrogels are taken into account. A free energy equation combining the slip-link model proposed by Edwards-Vilgis with Flory-Huggins theory is introduced to demonstrate the real influence of polymer network on large deformation of hydrogels in the chemo-mechanical coupling field. The critical stress and wavelength of unidirectional nonlinear buckling of two-dimensional hydrogel films were solved by analytical method, and the influence of the microstructure of polymer network that constitutes hydrogels on the buckling of hydrogel films under different external solution environment conditions was discussed.- 收稿日期:2020-03-02 基金项目:国家自然科学基金资助项目(11572109;11632005);河北省自然科学基金资助项目(11572109);河北省高校技术研究项目(ZD2017006) 第一作者:李涛(1989—),男,河北保定人,北京工业大学在读博士,主要从事智能软材料多物理场耦合行为研究. E-mail:1047427142@emails.bjut.edu.cn 通信作者:杨庆生(1962—),男,河北故城人,北京工业大学教授,博士,主要从事智能软材料多物理场耦合行为研究.E-mail:qsyang@bjut.edu.cn第6期李涛等:交联点官能度和网络缠结效应对凝胶薄膜屈曲失稳的影响The results show that the microstructure parameters of hydrogels have a significant influence on the incremental modulus of hydrogels and the critical stress and wavelength of the buckling of hydrogel firms when the value change of parameter is small. Reference | Related Articles | Metrics | Comments（0）

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Biocontrol and growth promotion mechanisms of Bacillus velezensis 3A3-15 LIU Xuejiao,LI Hongya,LI Shuna,ZHU Baocheng,GAO Tongguo Journal of Hebei University (Natural Science Edition)    2019, 39 (3): 302-310.   DOI: 10.3969/j.issn.1000-1565.2019.03.012 Abstract （753）      PDF（pc） （1427KB）（800）       Knowledge map    Save In order to reveal the biocontrol and promotion mechanism of Bacillus velezensis 3A3-15, PCR with 9 pairs of specific primers were used to detect genes related to inhibitory and growth promotion, and the ability to secrete indole-3-acetic acid(IAA)and siderophore was tested by the methods of Sackowski, Schwyn and Neiland, respectively. At the same time, the inhibitory substances of the fermentation broth were analyzed by high performance liquid chromatography-electrospray ionization mass spectrometry(HPLC-ESI-MS). Finally, the inhibitory mechanism of the strain was analyzed by plate dual-culture antagonistic test and spore germination inhibition test. Results showed that the inhibitory genes in B. velezensis 3A3-15 include yndJ, srfAB, ituC, bamC and fenD, the growth-promoting genes include ysnE and dhbC. The strain had a strong ability to secrete siderophore with a As/Ar value of 0.238, and its inhibitory substance was C14~C15 SurfactinA. Moreover, the secondary metabolites production of B.velezensis 3A3-15 could cause- DOI:10.3969/j.issn.1000-1565.2019.03.012贝莱斯芽孢杆菌3A3-15生防和促生机制刘雪娇,李红亚,李术娜,朱宝成,高同国(河北农业大学 生命科学学院,河北 保定 071000)摘 要:为揭示贝莱斯芽孢杆菌(Bacillus velezensis)3A3-15生防和促生作用相关机理,采用9对特异性引物对其抑菌基因和促生长基因进行PCR检测,并分别通过Sackowski法、Schwyn和Neiland法检测其分泌吲哚乙酸(IAA)和嗜铁素能力,通过高效液相色谱-电喷雾质谱(HPLC-ESI-MS)分析其发酵液抑菌成分,采用平板对峙实验和孢子萌发抑制实验分析该菌株的抑菌机理.结果表明,贝莱斯芽孢杆菌3A3-15中的抑菌基因包括yndJ、srfAB、ituC、bamC和fenD,促生长基因包括ysnE和dhbC.该菌株分泌嗜铁素能力较强,As/Ar值达到0.238,鉴定其抑菌物质为C14~C15 surfactinA,且贝莱斯芽孢杆菌3A3-15的次生代谢物能导致病原菌(尖孢镰刀菌)菌丝扭曲、膨大、畸形,对其孢子萌发抑制作用较强,抑制率达93.2%.以上结果说明贝莱斯芽孢杆菌3A3-15具有较好的生防和促生潜力,是防治尖孢镰刀菌引起的大豆根腐病的潜在菌株.关键词:贝莱斯芽孢杆菌;生防作用;促生作用中图分类号:S476 文献标志码:A 文章编号:1000-1565(2019)03-0302-09Biocontrol and growth promotion mechanisms of Bacillus velezensis 3A3-15LIU Xuejiao,LI Hongya,LI Shuna,ZHU Baocheng,GAO Tongguo(College of Life Sciences,Hebei Agricultural University,Baoding 071000,China)Abstract:In order to reveal the biocontrol and promotion mechanism of Bacillus velezensis 3A3-15, PCR with 9 pairs of specific primers were used to detect genes related to inhibitory and growth promotion, and the ability to secrete indole-3-acetic acid(IAA)and siderophore was tested by the methods of Sackowski, Schwyn and Neiland, respectively. At the same time, the inhibitory substances of the fermentation broth were analyzed by high performance liquid chromatography-electrospray ionization mass spectrometry(HPLC-ESI-MS). Finally, the inhibitory mechanism of the strain was analyzed by plate dual-culture antagonistic test and spore germination inhibition test. Results showed that the inhibitory genes in B. velezensis 3A3-15 include yndJ, srfAB, ituC, bamC and fenD, the growth-promoting genes include ysnE and dhbC. The strain had a strong ability to secrete siderophore with a As/Ar value of 0.238, and its inhibitory substance was C14~C15 SurfactinA. Moreover, the secondary metabolites production of B.velezensis 3A3-15 could cause- 收稿日期:2018-10-12 基金项目:河北省自然科学基金资助项目(C2015204031);河北省高等学校科学技术研究项目(BJ2016029) 第一作者:刘雪娇(1991—),女,河北廊坊人,河北农业大学在读硕士研究生,主要从事植物真菌病害及生物防治研究. E-mail:956760741@qq.com 通信作者:高同国(1984—),男,河北邢台人,河北农业大学讲师,博士,主要从事植物真菌病害及生物防治研究.E-mail:gtgrxf@163.com第3期刘雪娇等:贝莱斯芽孢杆菌3A3-15生防和促生机制the hyphae of the pathogenic bacteria(Fusarium oxysporum)to distort, swellen, deform and had a strong inhibitory effect on the germination of spores, with the inhibition rate of 93.2%. These results indicated that B. velezensis 3A3-15 had preferable biocontrol and growth promoting potential and was a potential strain to control soybean root rot caused by F. oxysporum. Reference | Related Articles | Metrics | Comments（0）

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Role of Light in Plant Development Journal of Hebei University (Natural Science Edition)    2001, 21 (3): 341-346.   DOI: 10.3969/j.issn.1000-1565.2001.03.031 Abstract （745）      PDF（pc） （155KB）（1654）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）

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Choquet fuzzy integral classifier based on extreme learning machine CHEN Aixia,ZHANG Chunqin Journal of Hebei University (Natural Science Edition)    2019, 39 (4): 337-341.   DOI: 10.3969/j.issn.1000-1565.2019.04.001 Abstract （737）      PDF（pc） （409KB）（213）       Knowledge map    Save In the interactive environments,fuzzy integral classifier has shown its good classification performance. A key problem in the fuzzy integral classifier is to determine the fuzzy measure defined in the power set of attributes. The computational complexity increases exponentially as the number of attributes increases. In order to solve the problem, drawing lessons from the idea of random determination of weight vector in extrem learning machine algorithm, this paper puts forward an ELM-Choquet fuzzy integral classifier. The experiment result shows that compared with the Choquet fuzzy integral classifier, this algorithm has better classification performance. Reference | Related Articles | Metrics | Comments（0）

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Species diversity and ecological adaptability of AM fungi in Broussonetia papyrifera from Fengfeng mining area in Hebei Province LI Huajian,HE Xueli Journal of Hebei University (Natural Science Edition)    2019, 39 (3): 278-287.   DOI: 10.3969/j.issn.1000-1565.2019.03.009 Abstract （733）      PDF（pc） （1627KB）（408）       Knowledge map    Save In order to explore species diversity of arbuscular mycorrhizal(AM)fungi from Broussonetia papyrifera in Fengfeng mining area of Hebei Province and their ecological adaptability to polluted environment, soil samples from 0-20 cm and 20-40 cm soil layers around Broussonetia papyrifera roots were collected from Yijing Town, Jiecheng Town and Fengfeng Town in Fengfeng Mining Area in October 2016. The AM fungis germplasm resources, ecological distribution and correlation with soil factors were systematically studied. A total of 8 generas and 43 species of AM fungis were identified, Acaulospora and Glomus were of broad-spectrum ecotypes, G.reticulatum, Entrophospora infrequens, G.multiforum were of broad-spectrum ecotypes. Shannon-Weiner index, evenness and species richness of AM fungi in Yijing Town were the highest, while those in Jiecheng Town were the lowest. The content of heavy metal cadmium and zinc exceeded the standard in Fengfeng mining area. The correlation analysis showed that an extremely significant positive correlation was found between the spore density and total glomalin, a significant- DOI:10.3969/j.issn.1000-1565.2019.03.009河北峰峰矿区构树AM真菌物种多样性及生态适应性李华健,贺学礼(河北大学 生命科学学院,河北 保定 071002)摘 要:为探究河北峰峰矿区构树(Broussonetia papyrifera)arbuscular mycorrhizal(AM)真菌物种多样性及其对污染环境的生态适应性,2016年10月从峰峰矿区义井镇、界城镇与峰峰镇样地采集构树根围0~20 cm和20~40 cm土层土壤样品,系统研究AM真菌种质资源、生态分布以及与土壤因子的相关性.共分离鉴定AM真菌8属43种,其中无梗囊霉属(Acaulospora)和球囊霉属(Glomus)为广谱生态型属,网状球囊霉(G.reticulatum)、稀有内养囊霉(Entrophospora infrequens)、凹坑球囊霉(G.multiforum)为广谱生态型种.义井镇AM真菌香农-威纳指数、均匀度和种丰度最高,界城镇最低.峰峰矿区重金属镉和锌含量超标.相关性分析可知,孢子密度与总球囊霉素极显著正相关,与土壤碱解氮显著正相关,与镉含量显著负相关,土壤总球囊霉素与有机碳显著正相关,与镉含量显著负相关.峰峰矿区构树部分地区部分AM真菌孢子具有颜色深、表面网纹间隔致密等生态适应性特征,有利于AM真菌在污染土壤中分布和活动.关键词:AM真菌;构树;重金属污染;土壤因子;河北峰峰矿区中图分类号:X172 文献标志码:A 文章编号:1000-1565(2019)03-0278-10Species diversity and ecological adaptability of AM fungi in Broussonetia papyrifera from Fengfeng mining area in Hebei ProvinceLI Huajian,HE Xueli(College of Life Sciences,Hebei University,Baoding 071002,China)Abstract:In order to explore species diversity of arbuscular mycorrhizal(AM)fungi from Broussonetia papyrifera in Fengfeng mining area of Hebei Province and their ecological adaptability to polluted environment, soil samples from 0-20 cm and 20-40 cm soil layers around Broussonetia papyrifera roots were collected from Yijing Town, Jiecheng Town and Fengfeng Town in Fengfeng Mining Area in October 2016. The AM fungis germplasm resources, ecological distribution and correlation with soil factors were systematically studied. A total of 8 generas and 43 species of AM fungis were identified, Acaulospora and Glomus were of broad-spectrum ecotypes, G.reticulatum, Entrophospora infrequens, G.multiforum were of broad-spectrum ecotypes. Shannon-Weiner index, evenness and species richness of AM fungi in Yijing Town were the highest, while those in Jiecheng Town were the lowest. The content of heavy metal cadmium and zinc exceeded the standard in Fengfeng mining area. The correlation analysis showed that an extremely significant positive correlation was found between the spore density and total glomalin, a significant- 收稿日期:2018-09-23 基金项目:国家自然科学基金资助项目(31270460);河北省自然科学基金资助项目(C2014201060);河北大学研究生创新项目(X201701) 第一作者:李华健(1993—),男,河北邯郸人,河北大学在读硕士研究生,主要从事菌根生物学研究.E-mail:1138345738@qq.com 通信作者:贺学礼(1964—),男,陕西蒲城人,河北大学教授,博士生导师,主要从事生态学研究.E-mail:xuelh1256@aliyun.com第3期李华健等:河北峰峰矿区构树AM真菌物种多样性及生态适应性positive correlation was found between the spore density and soil alkalihydrolyzed nitrogen, a significant positive correlation was found between the spore density and cadmium content, a significant positive correlation was found between the total glomalin and organic carbon, and a significant positive correlation was found between the total glomalin and cadmium content. Some spores of AM fungi from Broussonetia papyrifera in some areas of Fengfeng mining area have the characteristics of dark color, dense surface reticulation spacing and other ecological adaptability, which is conducive to the distribution and activity of AM fungi in contaminated soil. Reference | Related Articles | Metrics | Comments（0）

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Flame retardant effects of GUP and sodium silicate on wood ZHAO Juanjuan, LIU Gang, GAO Ming Journal of Hebei University (Natural Science Edition)    2019, 39 (3): 264-269.   DOI: 10.3969/j.issn.1000-1565.2019.03.007 Abstract （722）      PDF（pc） （1469KB）（301）       Knowledge map    Save Wood was treated by guanyl urea phosphate(GUP)firstly and sodium silicate(Na2SiO3)secondly to impart flame retardance. The flame retarding properties of the treated samples were investigated by cone calorimeter and the thermal behaviors of these samples were studied by differential thermogravimetry(DTG)and thermogravimetry(TG)in air. It was found that the combustion parameters including peak of heat release rate(HRRpeak), total heat release(THR), smoke production rate(SPR), total smoke product(TSP)and the yield of CO2(YCO2)were decreased considerably by the treatment of GUP and Na2SiO3 when compared with those of the untreated samples. Furthermore, wood treated by both GUP and Na2SiO3 had better flame retarding properties than that by only GUP possibly because GUP could accelerate dehydration and carbonation, and simultaneously Na2SiO3 could relatively increase the activation energy of cellulose, which resulted in the enhancement of wood thermal stabilization. Reference | Related Articles | Metrics | Comments（0）

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An urban traffic congestion analysis based on the interpretive structure model and MICMAC JIA Fan Journal of Hebei University (Natural Science Edition)    2020, 40 (4): 344-350.   DOI: 10.3969/j.issn.1000-1565.2020.04.002 Abstract （722）      PDF（pc） （812KB）（521）       Knowledge map    Save Through the investigation of the current situation of urban traffic congestion, the 11 main factors causing urban traffic congestion are summarized from the three aspects, management, facilities and traffic participants. The model of interpretative structure is established, and the hierarchical relationship among factors is analyzed. The MICMAC analysis classifies the influencing factors, further analyzes the influence of each factor on the traffic congestion, finds the surface, middle and bottom influencing factors that cause the urban traffic congestion, and provides the basis for reference to alleviate the urban traffic congestion problem. Reference | Related Articles | Metrics | Comments（0）

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Research status of novel gene editing technology of CRISPR/Cas9 system QIAN Leiyang,ZHOU Zhijun,CHANG Yanlin Journal of Hebei University (Natural Science Edition)    2016, 36 (1): 84-93.   DOI: 10.3969/j.issn.1000-1565.2016.01.014 Abstract （721）      PDF（pc） （634KB）（651）       Knowledge map    Save Clustered regularly interspaced short palindromic repeats(CRISPR)and associated proteins(Cas)comprise the CRISPR/Cas system,which confers adaptive immunity against foreign invading phages,plasmids and other mobile elements in many bacteria and most archaea.On the basis of the species and homology of the Cas protein,CRISPR/Cas systems have been classified into three distinct groups(type Ⅰ~Ⅲ).The component of type Ⅱ CRISPR/Cas9 system is the simplest one,and is well-charactered in resent study.CRISPR/Cas9 system modified by genetic engineering has proven to be an efficient gene-targeting tool in various organisms.Here,the auther review the discovery,components,molecular mechanism,applications,challenges and future prospect of CRISPR/Cas9-mediated genome editing. Reference | Related Articles | Metrics | Comments（0）

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Application of data recovery in the electronic data forensics and judicial identification MA Guofu,MA Shengli,WANG Zixian,LI Shuangyin,CHENG Yusi Journal of Hebei University (Natural Science Edition)    2015, 35 (5): 538-545.   DOI: 10.3969/j.issn.1000-1565.2015.05.016 Abstract （721）      PDF（pc） （938KB）（592）       Knowledge map    Save Related Articles | Metrics | Comments（0）

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Synthesis , Crystal Structure and Characterization of the Waugh-type Compound (NH4)2(C5H6N)4MnMo9O32·8H2O LIU Xue-mei*, HU Zi-yi, LIU Man-fei，JIANG Fang Journal of Hebei University (Natural Science Edition)    2015, 35 (2): 153-158.   DOI: 10.3969/j.issn.1000-1565.2015.02.008 Abstract （714）      PDF（pc） （1556KB）（643）       Knowledge map    Save A new Waugh molybdate formulated as (NH4)2(C5H6N)4MnMo9O32·8H2O has been isolated by reacting of (NH4)6MnMo9O32·6H2O and pyridine in aqueous solution, and characterized by single X-ray diffraction, elemental analysis, IR and solid UV-Vis diffuse reflectance spectroscopy. Crystal structural analysis indicate that the title compound crystallizes in the monoclinic system with space group P21/c, a = 2.1805(17) nm, b = 1.4394(11) nm, c = 1.5707(12) nm,, β = 106.68(10)°, V = 4.7225(6) nm3, Z = 4, Dc = 3.386g cm-3, R1 = 0.0586, wR2 = 0.1831 (I>2, GOF = 1.058. Reference | Related Articles | Metrics | Comments（0）

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Note on deep architecture and deep learning algorithms LI Haifeng,LI Chunguo Journal of Hebei University (Natural Science Edition)    2012, 32 (5): 538-544.   DOI: 10.3969/j.issn.1000-1565.2012.05.016 Abstract （713）      PDF（pc） （1640KB）（1914）       Knowledge map    Save Reference | Related Articles | Metrics | Comments（0）