Journal of Hebei University(Natural Science Edition) >

2019 , Vol. 39 >Issue 4: 366 - 371

DOI: https://doi.org/10.3969/j.issn.1000-1565.2019.04.006

anticancer effect of degradable nano-yttrium oxide hollow sphere drug delivery system

  • HAN Yu ,
  • ZHANG Fangbo ,
  • YU Linkang ,
  • JIA Guang ,
  • GE Kun
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  • Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry & Environmental Science, Hebei University, Baoding 071002, China

Received date: 2019-02-25

  Online published: 2019-07-25

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Abstract

Nano-yttrium oxide hollow sphere has broad application in the field of biological medicine.The uniform and well-dispersed Y2O3 hollow spheres(HYNPs)have been fabricated using phenolic resin spheres as template.The HYNP snot only exhibited a high DOX loading and release efficiency, but also showed the pH-sensitive degradableand drug release profiles. And the DOX release from the HYNPs-DOX in the cells increased with time. Moreover, the low cytotoxicity of HYNPs was found on MCF-7and MDA-MB-231 cells. When loaded with DOX, HYNPs-DOX exhibited a good anticancer efficiency in vitro, which showed a great potential in cancer treatment.

Key words： Y2O3 nanoparticle; hollow sphere; drug loading; drug release; anticancer

Cite this article

HAN Yu , ZHANG Fangbo , YU Linkang , JIA Guang , GE Kun . anticancer effect of degradable nano-yttrium oxide hollow sphere drug delivery system[J]. Journal of Hebei University(Natural Science Edition), 2019 , 39(4) : 366 -371 . DOI: 10.3969/j.issn.1000-1565.2019.04.006

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