Experimental research on dynamic process of bubble generation and trapping induced by self-focused femto-second laser pulses using fast-frame video microscopy and high frequency ultrasound imaging.Experimental results indicate that after the appearance of a series of microbubbles around the laser focus, a single microbubble generated via laser induced optical breakdown(LIOB)could be trapped stably by the self-focused SF femtosecond laser in water.The trapped bubble could be operated in the non-contact and three-dimensional way afterwards.Furthermore, the spatiotemporal and mechanical characteristics of bubble generation and trapping by self-focused femtosecond laser pulses at multiple locations along the laser beam were discussed.The experimental results can supply with new technological supports for the application of microbubble in targeted therapy at molecular level.
XUE Linyan
,
YANG Kun
,
CAO Biao
,
YAN Weina
,
LIU Yuhang
,
LIU Shuang
. Experimental research of microbubble generation and trapping induced by femto-second laser pulses[J]. Journal of Hebei University(Natural Science Edition), 2019
, 39(4)
: 359
-365
.
DOI: 10.3969/j.issn.1000-1565.2019.04.005
[1] 叶佳丹,余克富,朱斌,等.肿瘤靶向药物的分类与研究进展[J].药学进展, 2018,42(5):351-358.
[2] RAWAT A, VAIDYA B, KHATRI K, et al.Targeted intracellular delivery of therapeutics: an overview[J].Pharmazie, 2007, 62(9): 643-658.DOI:10.1007/s00248-008-9473-9.
[3] KEELER A M, ELMALLAH M K, FLOTTE T R.Gene therapy 2017: progress and future directions[J].Clinical and Translational Science, 2017,10(4):242-248.DOI:10.1111/cts.12466.
[4] GARIBAY A P R D.Endocytosis in gene therapy with non-viral vectors[J].Wiener Medizinische Wochenschrift, 2016, 166(7-8): 227-235.DOI:10.1007/s10354-016-0450-5.
[5] DUAN X, CHAN K T, LEE K K H, et al.Oxidative stress and plasma membrane repair in single myoblasts after femtosecond laser photoporation[J].Annals of Biomedical Engineering, 2015,43(11):2735-2744.DOI:10.1007/s10439-015-1341-4.
[6] FOLDVARI M, NAZARALI A, ELSABAHY M.Non-viral nucleic acid delivery: key challenges and future directions[J].Curr Drug Deliv, 2011, 8(3): 1-10.DOI:10.2174/156720111795256174.
[7] HEISER W C.Delivery of DNA to cells in culture using particle bombardment[J].Methods Mol Biol, 2004, 245: 175-184.DOI:10.1385/1-59259-649-5:175.
[8] DENG C X, SIELING F, PAN H, et al.Ultrasound-induced cell membrane porosity[J].Ultrasound in Medicine & Biology, 2004, 30(4): 519-526.DOI:10.1016/j.ultrasmedbio.2004.01.005.
[9] JACKSON J D.Classical Electrodynamics[J].Physics Today, 1998, 30(5226): 832.DOI:10.1063/1.3037637.
[10] POTEMKIN F, MAREEV E.Dynamics of multiple bubbles, excited by a femtosecond filament in water[J].Laser Physics Letters, 2015,12(1):015405.DOI:10.1088/1612-2011/12/1/015405.
[11] ZHOU Y, YANG K, CUI J, et al.Controlled permeation of cell membrane by single bubble acoustic cavitation[J].Journal of Controlled Release, 2012,157(1):103-111.DOI:10.1016/j.jconrel.2011.09.068.
[12] JOSÉ ERNESTO ALBAARROYO, QUINTOSU P A, CARMONASOSA V.Characterization of periodic cavitation in optical tweezers[J].Journal of Environmental Radioactivity, 2016, 102(6):543-550.DOI:10.1002/(SICI)1520-636X(2000)12:5/6<529:: AID-CHIR41>3.0.CO;2-3.
[13] VOGEL A, VENUGOPALAN V.Mechanisms of pulsed laser ablation of biological tissues[J].Chemical Reviews,2003,103(5): 2079-2079.DOI:10.1002/chin.200318293.
[14] 倪晓武, 陈笑, 陆建.激光与液态物质相互作用机理的研究进展[J].激光技术, 2002,26(4):258-261.DOI:10.3969/j.issn.1001-3806.2002.04.003.
