Journal of Hebei University(Natural Science Edition) >

2022 , Vol. 42 >Issue 2: 199 - 207

DOI: https://doi.org/10.3969/j.issn.1000-1565.2022.02.014

Research progress of photodynamic therapy for osteomyelitis

  • ZHAO Jianxi ,
  • YIN Xiujuan ,
  • FANG Ziyuan ,
  • DU Zishuo ,
  • ZHU Lin ,
  • ZHAO Zhanjuan
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  • 1. Department of Radiology, Affiliated Hospital of Hebei University, Baoding 071002, China; 2. School of Clinical Medicine, Hebei University, Baoding 071002, China; 3. School of Basic Medicine Sciences, Hebei University, Baoding 071002, China; 4. College of Basic Medicine, Hebei Medical University, Shijiazhuang 050000, China

Received date: 2021-09-16

  Online published: 2022-04-12

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Abstract

Osteomyelitis is an infectious inflammation of deep tissues caused by bacterial infection. Persistent infection will lead to dissolution and necrosis of bone tissues. At present, it is difficult to cure osteomyelitis completely by surgical treatment and antibiotic treatment, and long-term use of antibiotics will make bacteria resistant, which makes it more difficult to treat osteomyelitis. Photodynamic antibacterial chemotherapy(PACT)is a new method of anti-infection treatment. Infection caused by drug-resistant bacteria has a good curative effect. This paper introduces the causes of refractory osteomyelitis, the advantages of PACT in the treatment of osteomyelitis and the recent experimental research progress. With the in-depth study of PACT for osteomyelitis, PACT is expected to become a new method to completely cure osteomyelitis.

Key words： photodynamic antibacterial chemotherapy(PACT); osteomyelitis; photosensitizer; multi-drug resistant bacteria

Cite this article

ZHAO Jianxi , YIN Xiujuan , FANG Ziyuan , DU Zishuo , ZHU Lin , ZHAO Zhanjuan . Research progress of photodynamic therapy for osteomyelitis[J]. Journal of Hebei University(Natural Science Edition), 2022 , 42(2) : 199 -207 . DOI: 10.3969/j.issn.1000-1565.2022.02.014

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