Two component binary phase diagram analysis method was used to screen the eutectic system of the insoluble drug dipyridamole, and DSC, PXRD and FTIR techniques were used to characterize it. Subsequently, the solubility and dissolution of dipyridamole in the eutectic system were studied, and the solubilization mechanism of the eutectic system was studied by fluorescence quenching and phase solubility methods. The results showed that dipyridamole and nicotinamide formed a “V” type binary phase diagram with a single melting point, which proved that they formed a eutectic system. The solubility and dissolution rate of dipyridamole were improved by this system. Fluorescence spectra showed that there was a complexation effect between dipyridamole and nicotinamide. The phase solubility results further showed that a soluble complex was formed between the two, and the molar ratio of 1∶1. The complexation constants at 25 ℃ and 37 ℃ were 150.22 L/mol and 85.14 L/mol, respectively. The complexation reaction was endothermic, and the temperature rise was not conducive to the complexation of dipyridamole and nicotinamide.
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