Journal of Hebei University(Natural Science Edition) >

2023 , Vol. 43 >Issue 5: 512 - 516

DOI: https://doi.org/10.3969/j.issn.1000-1565.2023.05.010

Isolation and identification of secondary metabolites of Fusarium equiseti

  • PAN Huayang ,
  • LIU Huaguang ,
  • QI Zexin ,
  • ZHAO Xiaolong ,
  • LUO Duqiang
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  • 1. College of Chemistry and Materials Science, Hebei University, Baoding 071002, China; 2. College of Life Sciences, Hebei University, Baoding 071002, China

Received date: 2022-10-21

  Online published: 2023-10-25

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Abstract

In order to find compounds with new structures and significant pharmacological effects, three compounds 1, 2 and 3 were isolated and identified from the secondary metabolites of the endophytic fungus Fusarium equiseti from Harmonia axyridis by modern isolation methods. Among them, compounds 1(equisetin)and 2(epi-equisetin)are a pair of epiisomers, and 3(6-methoxy-droperylene)belongs to steroids. In vitro protein tyrosine phosphatase 1B(PTP1B)inhibitory activity test showed that compounds 1 and 2 had certain inhibitory activity on PTP1B, and IC50 values were(8.73 ± 0.03),(12.88 ± 0.16)μg/mL. It provides potential drug lead compounds for the development of new PTP1B inhibitors.

Key words： insect endophytic fungi; structure identification; activity test

Cite this article

PAN Huayang , LIU Huaguang , QI Zexin , ZHAO Xiaolong , LUO Duqiang . Isolation and identification of secondary metabolites of Fusarium equiseti[J]. Journal of Hebei University(Natural Science Edition), 2023 , 43(5) : 512 -516 . DOI: 10.3969/j.issn.1000-1565.2023.05.010

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