金纳米粒子与谷胱甘肽相互作用及其分析应用

doi:10.3969/j.issn.1000-1565.2007.03.012

河北大学学报(自然科学版) ›› 2007, Vol. 27 ›› Issue (3): 265-269.DOI: 10.3969/j.issn.1000-1565.2007.03.012

金纳米粒子与谷胱甘肽相互作用及其分析应用

许文杰¹,李正平²,段新瑞²,秦磊²

1.河北大学,医学部,河北,保定,071000； 2.河北大学,化学与环境科学学院,河北,保定,071002

出版日期:2007-05-25 发布日期:2007-05-25
基金资助:
教育部自然科学基金重点项目

Study on Interaction Between Gold Nanoparticles and Glutathione and Its Analytical Application

XU Wen-jie¹,LI Zheng-ping²,DUAN Xin-rui²,QIN Lei²

Online:2007-05-25 Published:2007-05-25

摘要/Abstract

摘要： 通过谷胱甘肽的巯基(-SH)与金纳米粒子的共价结合和氨基(-NH3+)与金纳米粒子的静电作用,使金纳米粒子自组装为有序的网状超分子结构,导致金纳米粒子的最大吸收波长从520 nm红移到668 nm,且在668 nm处的吸光度与谷胱甘肽的浓度在一定范围内呈正比.由此建立了以金纳米粒子为探针,简便、灵敏的测定谷胱甘肽的分析方法.本方法线性范围为0.01～0.20 mg/L,检出限3.0 μg/L(3 σ,9.8 nmol/L).

中图分类号:

O657.31

许文杰,李正平,段新瑞,秦磊. 金纳米粒子与谷胱甘肽相互作用及其分析应用[J]. 河北大学学报(自然科学版), 2007, 27(3): 265-269.

XU Wen-jie,LI Zheng-ping,DUAN Xin-rui,QIN Lei. Study on Interaction Between Gold Nanoparticles and Glutathione and Its Analytical Application[J]. Journal of Hebei University (Natural Science Edition), 2007, 27(3): 265-269.

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金纳米粒子与谷胱甘肽相互作用及其分析应用

Study on Interaction Between Gold Nanoparticles and Glutathione and Its Analytical Application

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