河北大学学报(自然科学版) ›› 2010, Vol. 30 ›› Issue (1): 53-57.DOI: 10.3969/j.issn.1000-1565.2010.01.012

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无溶剂合成2-氨基噻唑和2-甲基噻唑衍生物

王书香,武倩倩,段杰,郭少波   

  1. 河北大学,化学与环境科学学院,河北省化学生物学重点实验室,河北,保定,071002
  • 出版日期:2010-01-25 发布日期:2010-01-25
  • 基金资助:
    河北大学自然科学基金

Solvent-free Synthesis of 2-Aminothiazoles and 2-Methylthiazoles

WANG Shu-xiang,WU Qian-qian,DUAN Jie,GUO Shao-bo   

  • Online:2010-01-25 Published:2010-01-25

摘要: 在无溶剂和催化剂的条件下,以卤代酮和硫脲或取代硫脲为原料,于 100 ℃反应5~15 min,合成了2-氨基噻唑及2-甲基噻唑类衍生物.在明显减少硫脲或取代硫脲用量的基础上,使产物的收率达到了85%~98%.此方法具有反应条件温和、操作简单、反应时间短和收率高等特点.

关键词: 无溶剂, 无催化剂, 2-氨基噻唑, 2-甲基噻唑

Abstract: A series of 2-aminothiazoles, 2-methylthiazoles were synthesized by the reaction of phenacyl halides, thioura or thioacetamide under solvent-free and catalyst-free conditions. The reactions were completed within 5-15 min giving the yields of 85%-98%, and the amount of thioura or thioacetamide was reduced to equivalent mole. The procedure offers several advantages including milder reaction conditions, easier work-up, shorter reaction time, and higher yields.

Key words: solvent-free, catalyst-free, 2-aminothiazoles, 2-methylthiazoles

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