女性阿尔茨海默病患者静息态功能磁共振图像FC分析

doi:10.3969/j.issn.1000-1565.2018.05.014

河北大学学报(自然科学版) ›› 2018, Vol. 38 ›› Issue (5): 533-542.DOI: 10.3969/j.issn.1000-1565.2018.05.014

女性阿尔茨海默病患者静息态功能磁共振图像FC分析

郑伟^1,2,3,王轩^1,2,3,刘敬^1,2,3,赵杰^1,2,3

收稿日期:2018-04-10 出版日期:2018-09-25 发布日期:2018-09-25
通讯作者: 赵杰(1969—),男,河北沧州人,河北大学教授,博士,主要从事智能图像处理、图像处理与分析、信号检测与模式识别研究. E-mail: zhaojie_bbu@126.com
作者简介:郑伟(1972—),女,黑龙江兰西人,河北大学教授,博士,主要从事图像处理与分析、图像安全通信、图像加密和隐藏研究. E-mail: 147685650@qq.com
基金资助:
国家自然科学基金资助项目(61572063);河北省自然科学基金资助项目(F2016201187);河北省高等学校科学技术研究项目(QN2016085);河北大学研究生创新项目(X2017)

Functional connectivity analysis of resting state functional magnetic resonance imaging in female patients with Alzheimers disease

ZHENG Wei^1,2,3, WANG Xuan^1,2,3, LIU Jing^1,2,3, ZHAO Jie^1,2,3

1. College of Electronic and Information Engineering, Hebei University, Baoding 071002, China; 2.Key Laboratory of Digital Medical Engineering of Hebei Province, Baoding 071002, China; 3. Machine Vision Engineering Research Center of Hebei Province, Baoding 071002, China

Received:2018-04-10 Online:2018-09-25 Published:2018-09-25

摘要/Abstract

摘要： 利用静息态功能磁共振对阿尔茨海默病(Alzheimer disease,AD)患者发病机制和病理过程的研究结果表明AD患者脑功能的改变早于脑结构的改变,女性患病率是男性的2倍.针对不同年龄段女性患者静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI),基于SPM(statistical parametric mapping,SPM)对图像进行时间上的时间层校正以消除时间差;空间上的头动校正、归一化、平滑等操作降低个体间差异. 采用独立分量分析(independent component analysis,ICA)及聚类等方法进行盲源分离和稳定性分析,通过统计检验及组间对比研究女性患者各脑区之间的连接关系及其强弱,进而判断功能连接(functional connectivity,FC)差异,为女性AD患者临床前期诊断提供参考.

关键词: 阿尔茨海默病, 静息态, 功能磁共振成像, 独立分量分析, 功能连接

Abstract: The studies on the pathogenesis and pathological process of Alzheimers disease by resting state functional magnetic resonance show that changes in brain function of AD patients are earlier than changes in brain structure, and the prevalence rate of females is twice than that of males. According to the rs-fMRI for females of different ages, time layer correction is performed on the image based on SPM to eliminate the elimination of time difference; Head motion correction, normalization and smooth skating in space reduces the difference between individuals. The blind source separation and stability analysis were carried- DOI:10.3969/j.issn.1000-1565.2018.05.014女性阿尔茨海默病患者静息态功能磁共振图像FC分析郑伟^1,2,3,王轩^1,2,3,刘敬^1,2,3,赵杰^1,2,3(1. 河北大学电子信息工程学院,河北保定 071002;2.河北省数字医疗工程重点实验室,河北保定 071002;3.河北省机器视觉工程技术研究中心,河北保定 071002)摘要:利用静息态功能磁共振对阿尔茨海默病(Alzheimer disease,AD)患者发病机制和病理过程的研究结果表明AD患者脑功能的改变早于脑结构的改变,女性患病率是男性的2倍.针对不同年龄段女性患者静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI),基于SPM(statistical parametric mapping,SPM)对图像进行时间上的时间层校正以消除时间差;空间上的头动校正、归一化、平滑等操作降低个体间差异. 采用独立分量分析(independent component analysis,ICA)及聚类等方法进行盲源分离和稳定性分析,通过统计检验及组间对比研究女性患者各脑区之间的连接关系及其强弱,进而判断功能连接(functional connectivity,FC)差异,为女性AD患者临床前期诊断提供参考.关键词:阿尔茨海默病;静息态;功能磁共振成像;独立分量分析;功能连接中图分类号:TN911 文献标志码:A 文章编号:1000-1565(2018)05-0533-10Functional connectivity analysis of resting state functional magnetic resonance imaging in female patients with Alzheimers diseaseZHENG Wei^1,2,3, WANG Xuan^1,2,3, LIU Jing^1,2,3, ZHAO Jie^1,2,3(1. College of Electronic and Information Engineering, Hebei University, Baoding 071002, China; 2.Key Laboratory of Digital Medical Engineering of Hebei Province, Baoding 071002, China; 3. Machine Vision Engineering Research Center of Hebei Province, Baoding 071002, China)Abstract:The studies on the pathogenesis and pathological process of Alzheimers disease by resting state functional magnetic resonance show that changes in brain function of AD patients are earlier than changes in brain structure, and the prevalence rate of females is twice than that of males. According to the rs-fMRI for females of different ages, time layer correction is performed on the image based on SPM to eliminate the elimination of time difference; Head motion correction, normalization and smooth skating in space reduces the difference between individuals. The blind source separation and stability analysis were carried- 收稿日期:2018-04-10 基金项目:国家自然科学基金资助项目(61572063);河北省自然科学基金资助项目(F2016201187);河北省高等学校科学技术研究项目(QN2016085);河北大学研究生创新项目(X2017) 第一作者:郑伟(1972—),女,黑龙江兰西人,河北大学教授,博士,主要从事图像处理与分析、图像安全通信、图像加密和隐藏研究.E-mail: 147685650@qq.com 通信作者:赵杰(1969—),男,河北沧州人,河北大学教授,博士,主要从事智能图像处理、图像处理与分析、信号检测与模式识别研究. E-mail: zhaojie_bbu@126.com第5期郑伟等:女性阿尔茨海默病患者静息态功能磁共振图像FC分析out by the methods of independent component analysis(ICA)and clustering. The connection and strength of the brain regions of female patients were studied by statistical test and comparison, and then the difference of functional connectivity(FC)was judged, which provide reference for females AD patients in preclinical diagnosis.

Key words: Alzheimers disease, independent component analysis, resting state, functional magnetic resonance imaging, functional connectivity

中图分类号:

TN911

郑伟,王轩,刘敬,赵杰. 女性阿尔茨海默病患者静息态功能磁共振图像FC分析[J]. 河北大学学报(自然科学版), 2018, 38(5): 533-542.

ZHENG Wei, WANG Xuan, LIU Jing, ZHAO Jie. Functional connectivity analysis of resting state functional magnetic resonance imaging in female patients with Alzheimers disease[J]. Journal of Hebei University (Natural Science Edition), 2018, 38(5): 533-542.

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女性阿尔茨海默病患者静息态功能磁共振图像FC分析

Functional connectivity analysis of resting state functional magnetic resonance imaging in female patients with Alzheimers disease

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