诺氟沙星对水生生物细胞色素P450作用机制研究进展

doi:10.3969/j.issn.1000-1565.2020.06.011

河北大学学报(自然科学版) ›› 2020, Vol. 40 ›› Issue (6): 631-636.DOI: 10.3969/j.issn.1000-1565.2020.06.011

诺氟沙星对水生生物细胞色素P450作用机制研究进展

王宏伟^1,2,崔铁峰^1,2,张蒙^1,2,孙枭琼^1,2,方楠^1,2

收稿日期:2019-03-18 发布日期:2021-01-10
通讯作者: 国家自然科学基金联合项目(U1133005);河北省自然科学基金资助项目(C2019201390);教育部留学回国基金资助项目(201808130270);河北省高层次人才基金资助项目;国家自然科学基金资助项目(21207046);广东省自然科学基金资助项目(S2012010008396)
作者简介:王宏伟(1970—),女,河北张家口人,河北大学教授,博士,主要从事水生生物学研究. E-mail: wanghw6688@gmail.com

Progress in research on the mechanism of norfloxacin on cytochrome P450 in aquatic organisms

WANG Hongwei^1,2, CUI Tiefeng^1,2, ZHANG Meng^1,2, SUN Xiaoqiong^1,2,FANG Nan^1,2

1. School of Life Sciences, Hebei University, Baoding 071002, China; 2. Institute of Life Science and Green Development, Hebei University, Baoding 071002, China

Received:2019-03-18 Published:2021-01-10

摘要/Abstract

摘要： 环境中的抗生素主要来源于生活污水、医疗废水以及水产养殖废水等.2013年中国抗生素总使用量约为1.62×10⁵ t,其中48%为人用抗生素,其余为兽用抗生素.大量具有活性的抗生素经地表径流和城市排污管道最终积聚到河流湖泊中.这些活性物质会对水生生物产生危害,尤其是在较长的时间跨度上,这种危害会进一步扩大.文章概述了近几年基于细胞色素P450(cytochrome P450,CYP450)作为检测指标,诺氟沙星(norfloxacin,NFLX)对一些水生生物的生态毒理效应.同时介绍了NFLX对于选取的指标CYP450的影响机制,以及检测这些指标的可行性方法.

关键词: 诺氟沙星(NFLX), 细胞色素P450(CYP450), 水生生物

Abstract: Main sources of antibiotics in the environment were detected in sewage, medical wastewater and aquaculture wastewater. In 2013, the weight of the total use of antibiotics in China was about 1.62×10⁵ t, of which 48% were human antibiotics and the rest were veterinary antibiotics. A lot of them still have the activity of antibiotics. They were accumulated in rivers and lakes by the surface runoff, and urban sewage pipe in end. These active substances are harmful to aquatic organisms, especially over longer time spans, and this hazard will expand further. The article briefly outlined the research about the ecotoxicological effects of norfloxacin(NFLX)on some aquatic organisms in recent years, based on cytochrome P450(CYP450)as an indicator of detection. The influencing mechanism of NFLX on CYP450 as selected indicators was introduced, and the feasibility methods for testing these indicators was discussed.

Key words: norfloxacin(NFLX), cytochrome P450(CYP450), aquatic organisms

中图分类号:

S966.281

王宏伟,崔铁峰,张蒙,孙枭琼,方楠. 诺氟沙星对水生生物细胞色素P450作用机制研究进展[J]. 河北大学学报(自然科学版), 2020, 40(6): 631-636.

WANG Hongwei, CUI Tiefeng, ZHANG Meng, SUN Xiaoqiong,FANG Nan. Progress in research on the mechanism of norfloxacin on cytochrome P450 in aquatic organisms[J]. Journal of Hebei University(Natural Science Edition), 2020, 40(6): 631-636.

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诺氟沙星对水生生物细胞色素P450作用机制研究进展

Progress in research on the mechanism of norfloxacin on cytochrome P450 in aquatic organisms

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