超声辐射下利用Paal-Knorr反应合成多取代吡咯衍生物

doi:10.3969/j.issn.1000-1565.2009.06.015

摘要/Abstract

摘要： 研究了在超声辐射下几种1,4-二酮与取代的芳香伯胺进行的Paal-Knorr缩合反应.与传统的加热方法相比较,在超声辐射下利用Paal-Knorr缩合反应合成多取代吡咯具有产率高、时间短、条件温和以及实验操作步骤简单等诸多优点,具有一定的实用价值.

关键词: 超声辐射, Paal-Knorr反应, 1, 4-二酮, 芳香伯胺, 多取代吡咯

Abstract: Polysubstituted pyrroles were synthesized via ultrasonic-assisted Paal-Knorr condensation of 1,4-diketone with aromatic amines at room temperature. Compared with conventional heating method, the ultrasonic-assisted reaction showed certain practical value for it's higher yield, shorter reaction time, mild reaction condition, simple procedure and so on.

Key words: ultrasound irradiation, Paal-Knorr reaction, 1.4-diketone, aromatic amine, polysubstituted pyrroles

中图分类号:

O621.3

张书文,张星,魏保君,郝鹏鹏. 超声辐射下利用Paal-Knorr反应合成多取代吡咯衍生物[J]. 河北大学学报(自然科学版), 2009, 29(6): 618-622.

ZHANG Shu-wen,ZHANG Xing,WEI Bao-jun,HAO Peng-peng. Paal-Knorr Condensation for the Synthesis of Pyrrole Derivatives Under Ultrasound Irradiation[J]. Journal of Hebei University (Natural Science Edition), 2009, 29(6): 618-622.

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