阿比特龙环糊精包合物片剂的制备工艺

doi:10.3969/j.issn.1000-1565.2020.05.007

河北大学学报(自然科学版) ›› 2020, Vol. 40 ›› Issue (5): 494-499.DOI: 10.3969/j.issn.1000-1565.2020.05.007

阿比特龙环糊精包合物片剂的制备工艺

汤华阳¹,李建恒¹,许峰²

收稿日期:2019-10-20 出版日期:2020-09-25 发布日期:2020-09-25
通讯作者: 李建恒(1964—),男,河北徐水人,河北大学教授,主要从事重大疾病新药创制及中药品质提升的研究.E-mail: lijianheng@hbu.cn
作者简介:汤华阳(1992—),女,山东济宁人,河北大学在读硕士研究生,主要从事新药药理及制剂的研究. E-mail: 2576627566@qq.com
基金资助:
河北省重点研发计划新药创制技术专项(16272602D)

Preparation of abiraterone cyclodextrin inclusion complex tablets

TANG Huayang¹,LI Jianheng¹,XU Feng²

1.Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmacy, Hebei University, Baoding 071002, China; 2.Hebei Zhitong Biological Pharmaceutical Co., Ltd., Baoding 071000, China

Received:2019-10-20 Online:2020-09-25 Published:2020-09-25

摘要/Abstract

摘要： 研究了阿比特龙2-羟丙基-β-环糊精包合物片剂的最佳制备工艺.采用正交实验设计方法,以素片的崩解时限为考察指标,筛选最佳制备工艺.结果表明片剂的最佳制备工艺:乳糖15 g,交联羧甲基纤维素钠1 g,聚乙烯吡咯烷酮的质量分数为3%.通过优化制备的包合物片剂工艺稳定、可行.

关键词: 阿比特龙, 包合物片, 崩解时限, 溶出度, 生物利用度

Abstract: To study the best technie of the abiraterone-2- hydroxypropyl-β-cyclodextrin inclusion complex tablets. Orthogonal experiment was used to select of the best preparation technology by using the time limit of the disintegrating of vegetarian tablets as the investigation index. Best preparation of tablets are lactose 15 g, the amount of crosslinked sodium carboxymethylcellulose 1 g, 3%(g/g)binder. This method of preparation of the abiraterone-2-hydroxypropyl-β-cyclodextrin inclusion complex tablets is reasonable and reliable.

Key words: abiraterone, complex tablets, disintegration time limit, solubility, bioavailability

中图分类号:

汤华阳,李建恒,许峰. 阿比特龙环糊精包合物片剂的制备工艺[J]. 河北大学学报(自然科学版), 2020, 40(5): 494-499.

TANG Huayang,LI Jianheng,XU Feng. Preparation of abiraterone cyclodextrin inclusion complex tablets[J]. Journal of Hebei University (Natural Science Edition), 2020, 40(5): 494-499.

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阿比特龙环糊精包合物片剂的制备工艺

Preparation of abiraterone cyclodextrin inclusion complex tablets

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