环糊精诺氟沙星片剂的制备及溶出度考察

doi:10.3969/j.issn.1000-1565.2012.04.007

摘要/Abstract

摘要： 采用正交实验优化诺氟沙星片剂的制备条件,获得最佳处方:淀粉为填充剂,质量分数为5％的羧甲基淀粉钠(CMS-Na)为崩解剂,1％的滑石粉为润滑剂,10％的淀粉浆为黏合剂.为增大诺氟沙星药物的溶出,采用研磨法制备β-环糊精诺氟沙星包合物,经湿法制粒压片工艺制备环糊精诺氟沙星片剂.环糊精诺氟沙星片的片重差异、脆碎度和崩解时限均符合2010版中国药典要求,其中诺氟沙星的溶出度得到有效改善,解决了诺氟沙星片剂对照组的主药溶出度低的问题.采用优化处方和制备工艺,制备环糊精诺氟沙星片,可改善难溶性诺氟沙星药物的溶出度且工艺简单易行.

关键词: 诺氟沙星, 环糊精, 湿法制粒压片, 溶出度

中图分类号:

O658

杨文智,王芳,李海鹰,张亚静,李月龙. 环糊精诺氟沙星片剂的制备及溶出度考察[J]. 河北大学学报(自然科学版), 2012, 32(4): 369-374.

YANG Wen-zhi,WANG Fang,LI Hai-ying,ZHANG Ya-jing,LI Yue-long. Preparation of β-cyclodextrin norfloxacin tablets and evaluation its dissolution rate[J]. Journal of Hebei University (Natural Science Edition), 2012, 32(4): 369-374.

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