Quaterrylene-环糊精肿瘤光热治疗剂的大鼠肾-尿代谢研究

doi:10.3969/j.issn.1000-1565.2021.02.009

河北大学学报(自然科学版) ›› 2021, Vol. 41 ›› Issue (2): 166-170.DOI: 10.3969/j.issn.1000-1565.2021.02.009

Quaterrylene-环糊精肿瘤光热治疗剂的大鼠肾-尿代谢研究

李金梅¹,罗亚丽²,王克让²

收稿日期:2020-05-01 出版日期:2021-03-25 发布日期:2021-04-07
通讯作者: 王克让(1979—)
作者简介:李金梅(1980—),女,河北河间人,保定市第一中心医院副主任医师,主要从事肿瘤病理学研究.
E-mail:haitun111999@126.com
基金资助:
河北大学药物化学与分子诊断教育部重点实验室提升计划(ts2019002);保定市科技局项目(17ZF220)

Renal clearance of a photothermal therapy agent based on quaterrylene-cyclodextrin conjugates

LI Jinmei¹, LUO Yali², WANG Kerang²

1. Department of Pathology, The First Central Hospital of Baoding, Baoding 071000, China; 2. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China

Received:2020-05-01 Online:2021-03-25 Published:2021-04-07

摘要/Abstract

摘要： 光热治疗(photothermal therapy,PTT)是将光能转化为热能而达到治疗效果的一种新的治疗手段,然而代谢问题是其临床应用研究亟待解决的关键问题. 基于quaterrylene-环糊精衍生物(QDI-CD)良好的光热治疗效果,研究了其在sprague-dawley(SD)大鼠中的代谢情况,发现给药量为1 mg/只时,QDI-CD的平均代谢率为(48.74±11.80)%. 将SD大鼠尿液经分离后,高分辨质谱(HRMS)结果显示QDI-CD分子的结构与代谢前一致.

关键词: 光热治疗, 代谢, 环糊精, quaterrylene

Abstract: Photothermal therapy(PTT)is a promising avenue for precision cancer treatment. However, the metabolic clearance is a key issue for future clinical applications. In this paper, renal clearance of a cyclodextrin-modified quaterrylene bisimide derivative(QDI-CD)was studied. Importantly, QDI-CD administered to sprague-dawley(SD)rats by intraperitoneal injection was effectively cleared with renal clearance efficiency of(48.74 ± 11.80)% at 12 h after drug injection. In addition, the structure of QDI-CD in urines did not changed under the metabolism.

Key words: photothermal therapy, metabolic clearance, cyclodextrin, quaterrylene

中图分类号:

R73-37
R962

李金梅,罗亚丽,王克让. Quaterrylene-环糊精肿瘤光热治疗剂的大鼠肾-尿代谢研究[J]. 河北大学学报(自然科学版), 2021, 41(2): 166-170.

LI Jinmei, LUO Yali, WANG Kerang. Renal clearance of a photothermal therapy agent based on quaterrylene-cyclodextrin conjugates[J]. Journal of Hebei University(Natural Science Edition), 2021, 41(2): 166-170.

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Quaterrylene-环糊精肿瘤光热治疗剂的大鼠肾-尿代谢研究

Renal clearance of a photothermal therapy agent based on quaterrylene-cyclodextrin conjugates

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