艾叶配方颗粒的制备

doi:10.3969/j.issn.1000-1565.2022.03.006

河北大学学报(自然科学版) ›› 2022, Vol. 42 ›› Issue (3): 256-264.DOI: 10.3969/j.issn.1000-1565.2022.03.006

艾叶配方颗粒的制备

梁思怡¹,纪胜男¹,田璐肖¹,智静驿¹,李丽丽²,哈婧¹

收稿日期:2021-12-04 出版日期:2022-05-25 发布日期:2022-06-16
通讯作者: 哈婧(1970—)
作者简介:梁思怡(1997—),女,山西长治人,河北科技大学在读硕士研究生,主要从事药物分析研究.
E-mail:1042478460@qq.com
基金资助:
河北省自然科学基金资助项目(H20200824)

Preparation technology of Artemisia argyi formula granules

LIANG Siyi¹, JI Shengnan¹, TIAN Luxiao¹, ZHI Jingyi¹, LI Lili², HA Jing¹

1.School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China; 2.Hebei Yuzhilin Pharmaceutical Company Limited, Xingtai 054400, China

Received:2021-12-04 Online:2022-05-25 Published:2022-06-16

摘要/Abstract

摘要： 为减少标准汤剂和配方颗粒制备过程中挥发油的损失,将挥发油与β-环糊精(β-CD)包合,以挥发油的包合率为评价指标,优化艾叶挥发油与β-CD的包合工艺,并采用气相色谱法测定包合率.通过指标成分桉油精和龙脑的含量测定及指纹图谱考查饮片、标准汤剂、配方颗粒的相关性.最终确定最佳包合条件,所得挥发油平均包合率为96.40%,建立了艾叶标准汤剂和配方颗粒的制备方法,制得的配方颗粒中桉油精的平均质量分数0.738 4 mg/g,转移率33.48%,龙脑的平均质量分数0.334 1 mg/g,转移率25.41%.所建立包合工艺和配方颗粒制备工艺稳定性高,重复性好,标准汤剂和配方颗粒在指标成分含量上具有较好的一致性,可为企业工业化生产提供理论参考.

关键词: 色谱分析, 艾叶, 桉油精, 龙脑, β-环糊精

Abstract: In order to reduce the loss of volatile was oil in the preparation of standard decoction and formula granules, the volatile oil was included with β-cyclodextrin(β-CD), and the inclusion rate of volatile oil was used as an evaluation index to optimize the package of volatile oil and β-CD. Gas chromatography was used to determine the inclusion rate. The correlation among decoction pieces, standard decoction and formula granules was investigated by the content determination of index components and fingerprint. The average inclusion rate of volatile oil obtained by inclusion process was 96.40%, and the preparation method of Artemisia argyi standard decoction and formula granules was established. The average content of eucalyptus olein in the formula granules was 0.738 4 mg/g, and the transfer rate was 33.48%. The average content of borneol was 0.334 1 mg/g, and the transfer rate was 25.41%. The inclusion process and the preparation process of formula granules have high stability and good repeatability.The content of index components of standard decoction and formula granules is consistent, which can provide theoretical reference for industrial production of enterprises.

Key words: chromatographic analysis, Artemisia argyi, eucalyptol, borneol, β-cyclodextrin

中图分类号:

R917

梁思怡,纪胜男,田璐肖,智静驿,李丽丽,哈婧. 艾叶配方颗粒的制备[J]. 河北大学学报(自然科学版), 2022, 42(3): 256-264.

LIANG Siyi, JI Shengnan, TIAN Luxiao, ZHI Jingyi, LI Lili, HA Jing. Preparation technology of Artemisia argyi formula granules[J]. Journal of Hebei University(Natural Science Edition), 2022, 42(3): 256-264.

参考文献

[1] 雷琼.不同产地艾叶主要成分比较研究[D].杨凌:西北农林科技大学,2020. DOI:10.27409/d.cnki.gxbnu.2020.001224.
[2] 郑昆,钟肖飞,张华.艾叶挥发油类成分及其药理作用的研究进展[J].中国实验方剂学杂志,2020,26(18):224-234. DOI:10.13422/j.cnki.syfjx.20201917.
[3] JIANG Z T, TAN J, TAN J, et al. Chemical components and molecular microcapsules of folium artemisia argyi essential oil with β-cyclodextrin derivatives[J]. Journal of Essential Oil Bearing Plants, 2016, 19(5).:1155-1169. DOI:10.1080/0972060x.2016.1185973.
[4] 詹国平,郝丽.艾叶挥发油-羟丙基-β-环糊精包合物的制备[J].合成化学,2010,18(4):493-496. DOI:10.15952/j.cnki.cjsc.2010.04.036.
[5] 李真真,吕洁丽,张来宾,等.艾叶的化学成分及药理作用研究进展[J].国际药学研究杂志,2016,43(6):1059-1066. DOI:10.13220/j.cnki.jipr.2016.06.007.
[6] 张元,康利平,郭兰萍,等.艾叶的本草考证和应用研究进展[J].上海针灸杂志,2017,36(3):245-255. DOI:10.13460/j.issn.1005-0957.2017.03.0245.
[7] PANDEY B P, THAPA R, UPRETI A. Chemical composition, antioxidant and antibacterial activities of essential oil and methanol extract of Artemisia vulgaris and Gaultheria fragrantissima collected from Nepal[J]. Asian Pacific Journal of Tropical Medicine, 2017, 10(10): 952-959. DOI:10.1016/j.apjtm.2017.09.005.
[8] XIA J X, ZHAO B B, ZAN J F, et al. Simultaneous determination of phenolic acids and flavonoids in Artemisiae Argyi Folium by HPLC-MS/MS and discovery of antioxidant ingredients based on relevance analysis[J]. Journal of Pharmaceutical and Biomedical Analysis, 2019, 175:112734. DOI:10.1016/j.jpba.2019.06.031.
[9] 禹亚杰,包锐.中药配方颗粒质量控制研究现状分析与思考[J].智慧健康,2021,7(13):49-51. DOI:10.19335/j.cnki.2096-1219.2021.13.015.
[10] 叶心怡,陈更新.关于中药配方颗粒临床应用价值的思考[J].中医药管理杂志,2021,29(16):217-218. DOI:10.16690/j.cnki.1007-9203.2021.16.101.
[11] 曾瑾,陈平,尹竹君,等.中药配方颗粒质量保障关键技术及智能制造装备研究现状[J/OL].中药药理与临床:1-16[2021-05-24]. DOI:10.13412/j.cnki.zyyl.20210524.004.
[12] 张育贵,辛二旦,边甜甜,等.中药配方颗粒的发展分析[J].中医药通报,2019,18(4):44-47. DOI:10.14046/j.cnki.zyytb2002.2019.04.018.
[13] 谢谭芳.中药配方颗粒与标准汤剂等效性的研究概况[J].广东化工,2021,48(15):142-143. DOI:10.3969/j.issn.1007-1865.2021.15.054.
[14] 陈士林,代云桃.标准汤剂-提升中药配方颗粒质量的重要桥梁[N].中国医药报,2021-03-09(003).
[15] 郑佳成,李瑞雪,史博,等.功能化β-环糊精的制备及其应用研究进展[J].化工时刊,2021,35(6):21-24. DOI:10.16597/j.cnki.issn.1002-154x.2021.06.006.
[16] 田亚超,袁超,刘祎祯,等.β-环糊精辅助制备脱臭速溶大蒜粉[J].中国调味品,2021,46(8):92-95. DOI:10.3969/j.issn.1000-9973.2021.08.020.
[17] 邹新城.艾叶挥发油-β环糊精包合物的制备及其稳定性的研究[D].长沙:湖南农业大学,2010.
[18] 周瑶,陈岗,詹永,等.艾叶挥发油-环糊精包合物研究概述[J].食品工业,2020,41(8):240-244.
[19] 沈德凤,孟祥丽,杨波.艾叶挥发油β-环糊精包合物的制备[J].中国野生植物资源,2004(3):45-46. DOI:10.3969/j.issn.1006-9690.2004.03.017.
[20] KOSE M D, TEKIN B N, BAYRAKTAR O. Simultaneous isolation and selective encapsulation of volatile compounds from essential oil during electrospraying of β-Cyclodextrin[J]. Carbohydrate Polymers, 2021, 258(2):117673. DOI:10.1016/j.carbpol.2021.117673.
[21] 赵雨晴,张芯,穆开朗.安徽产薄荷挥发油提取工艺优化研究[J].湖北农业科学,2021,60(8):131-133. DOI:10.14088/j.cnki.issn0439-8114.2021.08.
[22] 国家药典委员会.中华人民共和国药典[M].北京:中国医药科技出版社,2020.
[23] 张志,张大委,高雪梅.艾叶挥发油-羟丙基-β-环糊精包合物的制备及鉴定[J].时珍国医国药,2018,29(6):1356-1357. DOI:10.3969/j.issn.1008-0805.
[24] 林瑞东. 川芎配方颗粒生产工艺和质量标准的研究[D].长春:吉林大学,2015.
[25] GE Y, WANG Z, XIONG Y, et al. Anti-inflammatory and blood stasis activities of essential oil extracted from Artemisia argyi leaf in animals[J]. Journal of Natural Medicines, 2016, 70(3):531-538. DOI:10.1007/s11418-016-0972-6
[26] 段迪,梁惠媛,吴秋霞,等. GC-MS结合化学计量学方法分析艾叶挥发油成分[J/OL].化学试剂, 2021,43(10):1313-1321. DOI:10.13822/j.cnki.hxsj.2021008215.
[27] 张丽佳,薛银,张岑容,等.桉油精的抗菌抗炎作用研究[J].中国兽药杂志,2013,47(3):21-24.
[28] 杨鹏飞,卢慧,王新峰,等.龙脑樟挥发油化学成分、抗烟草花叶病毒及抑菌活性研究[J].化学试剂,2021,43(8):1090-1094. DOI:10.13822/j.cnki.hxsj.2021008099. (

艾叶配方颗粒的制备

Preparation technology of Artemisia argyi formula granules

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 1

编辑推荐

Metrics

本文评价