在无溶剂和催化剂的条件下,以卤代酮和硫脲或取代硫脲为原料,于 100 ℃反应5～15 min,合成了2-氨基噻唑及2-甲基噻唑类衍生物.在明显减少硫脲或取代硫脲用量的基础上,使产物的收率达到了85%～98%.此方法具有反应条件温和、操作简单、反应时间短和收率高等特点.
A series of 2-aminothiazoles, 2-methylthiazoles were synthesized by the reaction of phenacyl halides, thioura or thioacetamide under solvent-free and catalyst-free conditions. The reactions were completed within 5-15 min giving the yields of 85%-98%, and the amount of thioura or thioacetamide was reduced to equivalent mole. The procedure offers several advantages including milder reaction conditions, easier work-up, shorter reaction time, and higher yields.
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