父代肥胖对精子表观遗传跨代继承的影响

  • 葛少钦 ,
  • 朱梦梦 ,
  • 封若雨 ,
  • 宋琦 ,
  • 王立鑫
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葛少钦(1967—),男,河北深州人,河北大学教授,博士,主要从事生殖基础研究. E-mail:gesq67@163.com

收稿日期: 2019-04-09

  网络出版日期: 2019-09-25

基金资助

河北省自然科学基金资助项目(H2018201218);河北省2016年度医学科学研究重点课题(20160049);河北省研究生创新项目(CXZZSS2019007)

Impact of parental obesity on sperm epigenetic intergenerational inheritance

  • GE Shaoqin ,
  • ZHU Mengmeng ,
  • FENG Ruoyu ,
  • SONG Qi ,
  • WANG Lixin
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  • 1. College of Traditional Chinese Medicine, Hebei University, Baoding 071002, China; 2. College of Basic Medical Science, Hebei University, Baoding 071002, China

Received date: 2019-04-09

  Online published: 2019-09-25

摘要

父代肥胖会导致精子表观遗传修饰的改变,这种异常的表观遗传修饰会传递至后代,对后代健康产生严重影响.本文主要综述了由于父代肥胖所致的DNA甲基化、组蛋白修饰和非编码RNA等表观遗传修饰的异常及其跨代继承的机制,从表观遗传水平阐述父代肥胖对自身和后代健康的影响,可为后代相关疾病的预防和诊断提供参考资料.

本文引用格式

葛少钦 , 朱梦梦 , 封若雨 , 宋琦 , 王立鑫 . 父代肥胖对精子表观遗传跨代继承的影响[J]. 河北大学学报(自然科学版), 2019 , 39(5) : 516 -521 . DOI: 10.3969/j.issn.1000-1565.2019.05.012

Abstract

Paternal obesity can lead to some defects of epigenetic modification in sperm, which is passed on to the offspring with a serious impact on the health. This article reviews the abnormal epigenetic modifications such as DNA methylation, histone modifications, and non-coding RNAs due to paternal obesity and the mechanism of intergenerational inheritance of paternal obesity, as well as the epigenetic effects from parental obesity on the health of parents and children, providing reference materials for prevention and diagnosis of the related diseases in offspring.

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