红酒中鞣酸和白藜芦醇含量测定及比较

  • 张园园 ,
  • 李佳佳 ,
  • 韩雪 ,
  • 张建平 ,
  • 楚立
展开
张园园(1987—),女,河北邢台人,河北中医学院讲师,河北中医学院在读博士,主要从事心血管药物方向研究. E-mail: zhangyuanyuan0815@163.com

收稿日期: 2018-06-29

  网络出版日期: 2019-09-25

基金资助

国家自然科学基金资助项目(81573669);河北省中医药管理局科研计划项目(2017022)

Quantitative determination and comparison the contents of tannic acid and resveratrol in red wine

  • ZHANG Yuanyuan ,
  • LI Jiajia ,
  • HAN Xue ,
  • ZHANG Jianping ,
  • CHU Li
Expand
  • 1. School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang 050200, China; 2. Department of pharmacy, The Fourth Hospital of Shifiazhuang, Shijiazhuang 050011, China; 3. School of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang 050200, China

Received date: 2018-06-29

  Online published: 2019-09-25

摘要

为了测定红酒中鞣酸和白藜芦醇的质量浓度,确定红酒中关于“法兰西悖论”的主要功效物质,采用高效液相色谱法,对市售4种不同品牌红酒进行了质量浓度测定. 结果显示红酒中鞣酸质量浓度为0.81~1.44 mg/mL,白藜芦醇质量浓度为0.14~2.49 mg/L,鞣酸质量浓度比白藜芦醇高约103倍. 随着对鞣酸心血管活性药理学研究的不断深入,提示鞣酸也可能是解释“法兰西悖论”的主要功效物质.

本文引用格式

张园园 , 李佳佳 , 韩雪 , 张建平 , 楚立 . 红酒中鞣酸和白藜芦醇含量测定及比较[J]. 河北大学学报(自然科学版), 2019 , 39(5) : 498 -503 . DOI: 10.3969/j.issn.1000-1565.2019.05.009

Abstract

To determine the content of tannic acid and resveratrol in red wine, and to identify the main functional substances in red wine about the “French paradox”, the high performance liquid chromatography(HPLC)was used to quantitative determine the contents of tannic acid and resveratrol in four different brands red wine. The results showed that the content of tannic acid in red wine was 0.81~1.44 mg /mL, and the content of resveratrol was 0.14~2.49 mg /L, that is to say, the content of tannin was about 103 times higher than resveratrol. Considering the more and more pharmacological studies on the cardiovascular activity of tannic acid, the results suggested that tannic acid may also be the main functional substance to explain the French paradox.

参考文献

[1] XIA N, DAIBER A, FORSTERMANN U, et al. Antioxidant effects of resveratrol in the cardiovascular system[J]. British Journal of Pharmacology, 2017, 174(12): 1633-1646. DOI: 10.1111/bph.13492.
[2] SHI Y, ZHOU J, JIANG B, et al. Resveratrol and inflammatory bowel disease[J]. Annals of the New York Academy of Science, 2017, 1403(1): 38-47. DOI: 10.1111/nyas.13426.
[3] BIRD JK, RAEDERSTORFF D, WEBER P, et al. Cardiovascular and antiobesity effects of resveratrol mediated through the gut microbiota[J]. Advances in Nutrition, 2017, 8(6): 839-849. DOI: 10.3945/an.117.016568.
[4] BONNEFONT-ROUSSELOT D. Resveratrol and cardiovascular diseases[J]. Nutrients, 2016, 8: 250. DOI: 10.3390/nu8050250.
[5] 冯愈钦, 郭红艳, 刘贵珊, 等. 宁夏葡萄酒中白藜芦醇含量的高效液相色谱[J]. 食品研究与开发, 2017, 38(5): 156-161. DOI: 10.3969/j.issn.1005-6521.2017.05.033.
[6] 刘庆, 曹福成, 孙英鸿[J]. 高效液相色谱法测定葡萄酒中白黎芦醇的含量[J]. 生命科学仪器, 2013, 11(2): 9-11.
[7] 赵丽青, 方佳茂, 肖向东, 等. 高效液相色谱法快速测定红酒中的白藜芦醇含量[J]. 广东化工, 2012, 39(7): 157-158.
[8] 程江峰, 王帅. 葡萄酒中白藜芦醇研究进展[J]. 酿酒科技, 2009(9): 102-106.
[9] CHU X, GUO Y, XU B, et al. Effects of tannic acid, green tea and red wine on hERG channels expressed in HEK293 Cells[J]. PloS One, 2015, 10: e0143797. DOI: 10.1371/journal.pone.0143797.
[10] ZHANG Y, CHU X, LIU L, et al. Tannic acid activates the Kv7.4 and Kv7.3/7.5 K(+)channels expressed in HEK293 cells and reduces tension in the rat mesenteric arteries[J]. The Journal of Pharmacy and Pharmacology, 2016, 68: 494-502. DOI: 10.1111/jphp.12527.
[11] CHU L, LI P, SONG T, et al. Protective effects of tannic acid on pressure overload-induced cardiac hypertrophy and underlying mechanisms in rats[J]. The Journal of Pharmacy and Pharmacology, 2017, 69: 1191-1207. DOI: 10.1111/jphp.12763.
文章导航

/

〈 〉