红酒中鞣酸和白藜芦醇含量测定及比较

doi:10.3969/j.issn.1000-1565.2019.05.009

河北大学学报(自然科学版) ›› 2019, Vol. 39 ›› Issue (5): 498-503.DOI: 10.3969/j.issn.1000-1565.2019.05.009

红酒中鞣酸和白藜芦醇含量测定及比较

张园园¹,李佳佳²,韩雪¹,张建平³,楚立¹

收稿日期:2018-06-29 出版日期:2019-09-25 发布日期:2019-09-25
通讯作者: 楚立(1957—),男,河北石家庄人,河北中医学院教授,博士生导师,主要从事心血管药物方向研究. E-mail: chuli0614@126.com
作者简介:张园园(1987—),女,河北邢台人,河北中医学院讲师,河北中医学院在读博士,主要从事心血管药物方向研究. E-mail: zhangyuanyuan0815@163.com
基金资助:
国家自然科学基金资助项目(81573669);河北省中医药管理局科研计划项目(2017022)

Quantitative determination and comparison the contents of tannic acid and resveratrol in red wine

ZHANG Yuanyuan¹, LI Jiajia², HAN Xue¹, ZHANG Jianping³, CHU Li¹

1. School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang 050200, China; 2. Department of pharmacy, The Fourth Hospital of Shifiazhuang, Shijiazhuang 050011, China; 3. School of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang 050200, China

Received:2018-06-29 Online:2019-09-25 Published:2019-09-25

摘要/Abstract

摘要： 为了测定红酒中鞣酸和白藜芦醇的质量浓度,确定红酒中关于“法兰西悖论”的主要功效物质,采用高效液相色谱法,对市售4种不同品牌红酒进行了质量浓度测定. 结果显示红酒中鞣酸质量浓度为0.81~1.44 mg/mL,白藜芦醇质量浓度为0.14~2.49 mg/L,鞣酸质量浓度比白藜芦醇高约10³倍. 随着对鞣酸心血管活性药理学研究的不断深入,提示鞣酸也可能是解释“法兰西悖论”的主要功效物质.

关键词: 高效液相色谱, 红酒, 鞣酸, 白藜芦醇, 法兰西悖论

Abstract: To determine the content of tannic acid and resveratrol in red wine, and to identify the main functional substances in red wine about the “French paradox”, the high performance liquid chromatography(HPLC)was used to quantitative determine the contents of tannic acid and resveratrol in four different brands red wine. The results showed that the content of tannic acid in red wine was 0.81~1.44 mg /mL, and the content of resveratrol was 0.14~2.49 mg /L, that is to say, the content of tannin was about 10³ times higher than resveratrol. Considering the more and more pharmacological studies on the cardiovascular activity of tannic acid, the results suggested that tannic acid may also be the main functional substance to explain the French paradox.

Key words: HPLC, red wine, tannic acid, resveratrol, French paradox

中图分类号:

O657.7

张园园,李佳佳,韩雪,张建平,楚立. 红酒中鞣酸和白藜芦醇含量测定及比较[J]. 河北大学学报(自然科学版), 2019, 39(5): 498-503.

ZHANG Yuanyuan, LI Jiajia, HAN Xue, ZHANG Jianping, CHU Li. Quantitative determination and comparison the contents of tannic acid and resveratrol in red wine[J]. Journal of Hebei University (Natural Science Edition), 2019, 39(5): 498-503.

参考文献

[1] XIA N, DAIBER A, FORSTERMANN U, et al. Antioxidant effects of resveratrol in the cardiovascular system[J]. British Journal of Pharmacology, 2017, 174(12): 1633-1646. DOI: 10.1111/bph.13492.
[2] SHI Y, ZHOU J, JIANG B, et al. Resveratrol and inflammatory bowel disease[J]. Annals of the New York Academy of Science, 2017, 1403(1): 38-47. DOI: 10.1111/nyas.13426.
[3] BIRD JK, RAEDERSTORFF D, WEBER P, et al. Cardiovascular and antiobesity effects of resveratrol mediated through the gut microbiota[J]. Advances in Nutrition, 2017, 8(6): 839-849. DOI: 10.3945/an.117.016568.
[4] BONNEFONT-ROUSSELOT D. Resveratrol and cardiovascular diseases[J]. Nutrients, 2016, 8: 250. DOI: 10.3390/nu8050250.
[5] 冯愈钦, 郭红艳, 刘贵珊, 等. 宁夏葡萄酒中白藜芦醇含量的高效液相色谱[J]. 食品研究与开发, 2017, 38(5): 156-161. DOI: 10.3969/j.issn.1005-6521.2017.05.033.
[6] 刘庆, 曹福成, 孙英鸿[J]. 高效液相色谱法测定葡萄酒中白黎芦醇的含量[J]. 生命科学仪器, 2013, 11(2): 9-11.
[7] 赵丽青, 方佳茂, 肖向东, 等. 高效液相色谱法快速测定红酒中的白藜芦醇含量[J]. 广东化工, 2012, 39(7): 157-158.
[8] 程江峰, 王帅. 葡萄酒中白藜芦醇研究进展[J]. 酿酒科技, 2009(9): 102-106.
[9] CHU X, GUO Y, XU B, et al. Effects of tannic acid, green tea and red wine on hERG channels expressed in HEK293 Cells[J]. PloS One, 2015, 10: e0143797. DOI: 10.1371/journal.pone.0143797.
[10] ZHANG Y, CHU X, LIU L, et al. Tannic acid activates the Kv7.4 and Kv7.3/7.5 K(+)channels expressed in HEK293 cells and reduces tension in the rat mesenteric arteries[J]. The Journal of Pharmacy and Pharmacology, 2016, 68: 494-502. DOI: 10.1111/jphp.12527.
[11] CHU L, LI P, SONG T, et al. Protective effects of tannic acid on pressure overload-induced cardiac hypertrophy and underlying mechanisms in rats[J]. The Journal of Pharmacy and Pharmacology, 2017, 69: 1191-1207. DOI: 10.1111/jphp.12763.

[1]	方雅莉,马骥. 超高效液相色谱-三重四极杆串联质谱法检测全血中常见安眠镇静类药物[J]. 河北大学学报(自然科学版), 2023, 43(2): 163-170.
[2]	韩晓利,刘广兴,李昳晴,郑佳妍,王庭欣. 鸡肉中盐酸硫利达嗪的高效液相色谱分析方法[J]. 河北大学学报(自然科学版), 2022, 42(6): 618-624.
[3]	侯慧云,徐梦蕾,郭昱娴,袁红莉,高同国,朱宝成. 黄腐酸对大豆内源激素的调控及结瘤能力的影响[J]. 河北大学学报(自然科学版), 2021, 41(6): 709-719.
[4]	蔺冬冬,侯亚璐,唐婷,柳峰松. 白藜芦醇对紫外线诱导家蝇氧化损伤的保护作用[J]. 河北大学学报(自然科学版), 2019, 39(5): 510-515.
[5]	刘丽艳,张宏馨,黄珊,廉海晨,白洁,韩艳梅,吴素焕. 双波长HPLC-荧光法同时测定褪黑素和维生素B6[J]. 河北大学学报(自然科学版), 2019, 39(5): 491-497.
[6]	李兴红,江静,杨莉纳,李美婷,何怡凡,张红医,石志红. 钴铁氧体磁性固相萃取结合高效液相色谱法测定果蔬汁中4种人工合成色素[J]. 河北大学学报(自然科学版), 2019, 39(1): 41-48.
[7]	李志伟,张任飞,刘颖娜,禹叶广,谢英花,仇燕. HPLC法测定甲苯磺酸依度沙班有关物质[J]. 河北大学学报(自然科学版), 2017, 37(5): 489-496.
[8]	赵燕燕,王静,刘丽艳,谷聪玲. [J]. 河北大学学报(自然科学版), 2017, 37(1): 31-38.
[9]	赵燕燕,柳亚飞,刘丽艳,孙东,王静. 大鼠肝微粒体中睾酮及其代谢产物 6β -羟基睾酮的高效液相色谱检测方法的改进[J]. 河北大学学报(自然科学版), 2016, 36(1): 43-51.
[10]	李志伟,夏瑾,何庆国,赵丽荣,李潇. 注射用复合维生素中草酸的HPLC法测定[J]. 河北大学学报(自然科学版), 2015, 35(3): 253-257.
[11]	赵燕燕,石敏健,刘丽艳,韩媛媛,李杨. 对中国国家药品标准甘草酸单铵盐中有关物质及含量检测方法的改进[J]. 河北大学学报(自然科学版), 2014, 34(4): 372-380.
[12]	赵杰,王菁菁,丁利杰,王庭欣,刘峥颢. 隆尧鸡腿葱中3种水溶性维生素含量分析[J]. 河北大学学报(自然科学版), 2014, 34(2): 181-186.
[13]	周建科,李向梅,付艳芳. 环境水样中苯脲类除草剂的光降解[J]. 河北大学学报(自然科学版), 2013, 33(6): 598-602.
[14]	孙娜,李挥,孙汉文. 超高效液相色谱测定肉制品中的罗丹明B、孔雀石绿和结晶紫及其代谢物残留[J]. 河北大学学报(自然科学版), 2013, 33(2): 154-160.
[15]	王庭欣,陈永刚,张晓瑜,夏立娅,李小亭. 冬枣中果糖、葡萄糖、蔗糖的高效液相色谱分析[J]. 河北大学学报(自然科学版), 2012, 32(5): 528-531.

红酒中鞣酸和白藜芦醇含量测定及比较

Quantitative determination and comparison the contents of tannic acid and resveratrol in red wine

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价