Progress in research on the mechanism of norfloxacin on cytochrome P450 in aquatic organisms

doi:10.3969/j.issn.1000-1565.2020.06.011

Abstract

Abstract: Main sources of antibiotics in the environment were detected in sewage, medical wastewater and aquaculture wastewater. In 2013, the weight of the total use of antibiotics in China was about 1.62×10⁵ t, of which 48% were human antibiotics and the rest were veterinary antibiotics. A lot of them still have the activity of antibiotics. They were accumulated in rivers and lakes by the surface runoff, and urban sewage pipe in end. These active substances are harmful to aquatic organisms, especially over longer time spans, and this hazard will expand further. The article briefly outlined the research about the ecotoxicological effects of norfloxacin(NFLX)on some aquatic organisms in recent years, based on cytochrome P450(CYP450)as an indicator of detection. The influencing mechanism of NFLX on CYP450 as selected indicators was introduced, and the feasibility methods for testing these indicators was discussed.

Key words: norfloxacin(NFLX), cytochrome P450(CYP450), aquatic organisms

CLC Number:

S966.281

WANG Hongwei, CUI Tiefeng, ZHANG Meng, SUN Xiaoqiong,FANG Nan. Progress in research on the mechanism of norfloxacin on cytochrome P450 in aquatic organisms[J]. Journal of Hebei University(Natural Science Edition), 2020, 40(6): 631-636.

References

[1] 戴纪刚,张国强,黄小兵,等.抗生素科学发展简史[J].中华医史杂志,1999(2): 3-5.
[2] 曾化松,王艳琳.抗生素滥用的现状及应对策略[J].中国卫生事业管理,2012,29(5):341-343. DOI:10.3969/j.issn.1004-4663. 2012.05.007.
[3] MIRTO S, DANOVARO R. Meiofaunal colonisation on artificial substrates: a tool for biomonitoring the environmental quality on coastal marine systems[J]. Mar Pollut Bull, 2004, 48(9-10): 919-926. DOI:10.1016/j.marpolbul.2003.11.016.
[4] CHING H H, JAY E RENEW, KRISTEN L SMEBY, et al. Assessment of potential antibiotic contaminants in water and preliminary occurrence analysis [J]. Journal of Contemporary Water Research & Education, 2011, 120(1):30-40. DOI: 10. 1142 /97898 127 99555_0004.
[5] 胡功政,李荣誉,许兰菊,等. 新全实用兽药手册[M]. 3版.郑州:河南科学技术出版社,2006.
[6] LALUMERA G M, CALAMARI D, GALLI P, et al. Preliminary investigation on the environmental occurrence and effects of antibiotics used in aquaculture in Italy[J]. Chemosphere, 2004, 54(5):661-668. DOI: 10.1016/j.chemosphere.2003.08.001.
[7] LI D, YANG X L, ZHANG S J, et al. Effects of mammalian CYP3A inducers on CYP3A-related enzyme activities in grass carp(Ctenopharyngodon idellus): Possible implications for the establishment of a fish CYP3A induction model[J]. Comp Biochem Physiol C Toxicol Pharmacol, 2008, 147(1):17-29. DOI: 10.1016/j.cbpc.2007.07.003.
[8] VACCARO E, GIORGI M, LONGO V, et al. Inhibition of cytochrome P450 enzymes by enrofloxacin in the sea bass(Dicentrarchus labrax)[J]. Aquat Toxicol, 2003, 62: 27-33. DOI: 10.1016/s0166-445x(02)00064-4.
[9] 张雅斌,张祚新,郑伟,等. 诺氟沙星在鱼类细菌性疾病中的应用研究[J]. 大连水产学院学报,2000, 15(2):79-85. DOI: 10.3969/j.issn.1000-9957.2000.02.001.
[10] 何良英.典型畜禽养殖环境中抗生素耐药基因的污染特征与扩散机理研究[D].广州:中国科学院研究生院(广州地球化学研究所),2016.
[11] 段可馨,韩冰,王荻,等.烟酸诺氟沙星在松浦镜鲤体内代谢残留规律的研究[J].江西农业大学学报,2016,38(2):356-361. DOI: 10.13836/j.jjau.2016050.
[12] 赵梦娇.我国抗生素滥用规制分析[J].中州大学学报,2017,34(1):73-75. DOI:10.13783/j.cnki.cn41-1275/g4.2017.01.015.
[13] 殷光权,赵扬,戴前梅.我国水体中抗生素的污染现状、危害及防治建议[J].安徽卫生职业技术学院学报,2017,16(5):6-8. DOI:10.3969/j.issn.1671-8054.2017.05.003.
[14] 丛琳,武瑞,李银生. 恩诺沙星对细胞色素P450酶系影响的研究进展[J]. 畜牧与饲料科学,2016, 37(1):34-36. DOI:10.39 69/j.issn.1672-5190.2016.01.012.
[15] LIU X N, LIANG P, GAO X W, et al. Induction of the cytochrome P450 activity by plant allelochemicals in the cotton bollworm, Helicoverpa armigera,(Hübner)[J]. Pesticide Biochemistry & Physiology, 2006, 84(2):127-134. DOI:10.1016/j.pestbp.2005.06.002
[16] 左梦丽,姚嘉赟,沈锦玉等. 烟酸诺氟沙星对乌鳢肝微粒酶活性的影响[J]. 水产研究,2016, 3(4): 88-96. DOI:10.12677/OJFR.2016.34014.
[17] YANG J F, LIU Y R, HUANG C C, et al. The time-dependent effects of St Johns wort on cytochrome P450, uridine diphosphate-glucuronosyltransferase, glutathione S-transferase, and NAD(P)H-quinone oxidoreductase in mice[J]. J Food Drug Anal, 2018, 26(1):422-431. DOI:10.1016/j.jfda.2017.01.004.
[18] MENG F D, MA P, SUI C G, et al. Association between cytochrome P450 1A1(CYP1A1)gene polymorphisms and the risk of renal cell carcinoma: a meta-analysis[J]. Sci Rep, 2015, 5(1):1-6. DOI: 10.1038/srep08108.
[19] SONG B J, AKBAR M, JO I, et al. Translational implications of the alcohol-metabolizing enzymes, including cytochrome P450-2E1, in alcoholic and nonalcoholic liver disease[J]. Advances in Pharmacology, 2015, 74:303. DOI: 10.1016/bs.apha.2015.04.002.
[20] 程婕,龚毅,杨凌.细胞色素P450酶系的异源表达研究[J].河北大学学报(自然科学版),2006,26(3):331-336. DOI: 10.3969/j.issn.1000-1565.2006.03.025.
[21] PANG K S, RODRIGUES A D, PETER R M. Enzyme- and transporter-based drug-drug interactions[M]. New York: Springer New York: 2010. DOI:10.1007/978-1-4419-0840-7.
[22] YU Y, ANANTHANARAYANAN A, SINGH N H, et al. TGFβ1-mediated suppression of cytochrome P450(CYP)induction responses in rat hepatocyte-fibroblast co-cultures[J]. Toxicology in Vitro, 2018,50:47-53. DOI:10.1016/j.tiv.2018.01.015.
[23] HU X J, ZHANG Y B, ZHAO Z J, et al. Metabolic detoxification of bakuchiol is mediated by oxidation of CYP 450s in liver microsomes[J]. Food and Chemical Toxicology, 2018:111:385-392. DOI: 10.1016/j.fct.2017.11.048.
[24] 徐莉.棉铃虫细胞色素P450CYP6B7基因过量表达及调控机制研究[D].北京:中国农业大学,2017.
[25] EKOW THOMFORD N, DZOBO K, ADU F, et al. Bush mint(Hyptis suaveolens)and spreading hogweed(Boerhavia diffusa)medicinal plant extracts differentially affect activities of CYP1A2, CYP2D6 and CYP3A4 enzymes[J]. Journal of Ethnopharmacology, 2018, 211:58-59. DOI: 10.1016/j.jep.2017.09.023.
[26] LI Y, ZHAO C, LU X, et al. Identification of a cytochrome P450 gene in the earthworm Eisenia fetida and its mRNA expression under enrofloxacin stress[J]. Ecotoxicology & Environmental Safety, 2018, 150:70-75. DOI: 10.1016/j.ecoenv.2017.12.020.
[27] 王宏伟,杨丽坤,赵文博,等. 诺氟沙星对中国圆田螺氨基比林-N-脱甲基酶活性的影响[J]. 水产科学,2017,36(4):519-523. DOI:10.16378/j.cnki.1003-1111.2017.04.020.
[28] EKSTRAND B, RASMUSSEN M K, WOLL F, et al. In vitro gender-dependent inhibition of porcine cytochrome P450 activity by selected flavonoids and phenolic acids[J]. Biomed Res Int, 2015,2015:1-7. DOI:10.1155/2015/387918.
[29] 张宁,喻文娟,王翔凌,等. 草鱼肝微粒体的提取及CYP酶活性的测定[J].海洋渔业,2007,29(2):148-152. DOI: 10.3969 /j.issn. 1004-2490.2007.02.009.
[30] 梁惜梅.诺氟沙星和三氯生对剑尾鱼的毒性效应[D].广州:暨南大学,2010.
[31] 张喆,李健,陈萍,等.诺氟沙星对中国明对虾鳃和血清ECOD、APND和GST活性的影响[J].中国水产科学,2012,19(3):514-520.DOI: 10.37241/SP.J.1118.2012.00514.
[32] 何秀婷,程章,聂湘平,等.诺氟沙星对阿部鲻鰕鯱Ⅰ相、Ⅱ相酶活性及CYP1A1和P-gpmRNA表达影响[J].环境科学学报,2011,31(4):846-853.DOI: 10.13671/j.hjkxxb.2011.04.002.