Efficacy and mechanism of the combined application of photodynamic antibacterial therapy and antibiotic on drug-resistant bacterial infection

doi:10.3969/j.issn.1000-1565.2025.03.004

Abstract

Abstract: Antibiotic therapy is currently the most critical means of controlling bacterial infections. However, antibiotic treatment is a major challenge due to increasing bacterial resistance. Photodynamic antimicrobial therapy(aPDT)uses reactive oxygen species to oxidize biological macromolecules to cause bacterial cell death, so bacteria are not susceptible to aPDT resistance. Antibiotics and aPDT are two different treatments for bacterial infections, both of which have good efficacy, but each has limitations. The combination of aPDT therapy with conventional antibiotics can achieve additive or synergistic therapeutic effects, and the inactivation effect of multidrug-resistant bacteria is more effective than that of a single approach. This article summarizes the current status of common drug-resistant bacterial infections in clinical practice, summarizes the therapeutic effects and mechanisms of different combinations of aPDT and antibiotics, and further points out the advantages, limitations and future development directions of combination therapy with aPDT and antibiotics, aiming to provide guidance for clinical application.- DOI:10.3969/j.issn.1000-1565.2025.03.004光动力抗菌疗法和抗生素联合应用对耐药菌感染的疗效及机制王建国¹,谢佳欣²,孔飞雁³,李昱潼³,赵占娟³(1.河北大学附属医院,检验科,河北保定 071000;2.河北大学临床医学院,河北保定 071000;3.河北大学基础医学院,河北保定 071000)摘要:抗生素治疗是控制细菌感染的关键手段,但随着细菌耐药性的不断增强,抗生素治疗面临着巨大挑战.光动力抗菌疗法(photodynamlc antibacterial therapy,aPDT)利用活性氧氧化生物大分子导致细菌死亡,使细菌不易对aPDT产生耐药性.这2种针对细菌感染的不同治疗方式,均具有良好的疗效,但各自存在局限性.将aPDT治疗与常规抗生素联合使用可实现相加或协同治疗效果,对耐多药细菌的灭活效果超过单一方法.本文概述了临床常见耐药菌感染现况,对aPDT与抗生素不同组合在治疗上的效果和作用机制进行了总结,进一步指出了aPDT与抗生素联合治疗的优势、局限性以及未来发展方向,旨在为临床应用提供指导.关键词:光动力抗菌疗法;多重耐药菌;抗生素;联合治疗中图分类号:R378 文献标志码:A 文章编号:1000-1565(2025)03-0254-12Efficacy and mechanism of the combined application ofphotodynamic antibacterial therapy and antibioticon drug-resistant bacterial infectionWANG Jianguo¹, XIE Jiaxin², KONG Feiyan³, LI Yutong³, ZHAO Zhanjuan³(1. Clinical Lab, Affiliated Hospital of Hebei University,Baoding 071000,China;2. School of Clinical Medicine, Hebei University, Baoding 071000,China;3. School of Basic Medicine, Hebei University,Baoding 071000,China)Abstract: Antibiotic therapy is currently the most critical means of controlling bacterial infections. However, antibiotic treatment is a major challenge due to increasing bacterial resistance. Photodynamic antimicrobial therapy(aPDT)uses reactive oxygen species to oxidize biological macromolecules to cause bacterial cell death, so bacteria are not susceptible to aPDT resistance. Antibiotics and aPDT are two different treatments for bacterial infections, both of which have good efficacy, but each has limitations. The combination of aPDT therapy with conventional antibiotics can achieve additive or synergistic therapeutic effects, and the inactivation effect of multidrug-resistant bacteria is more effective than that of a single approach. This article summarizes the current status of common drug-resistant bacterial infections in clinical practice, summarizes the therapeutic effects and mechanisms of different combinations of aPDT and antibiotics, and further points out the advantages, limitations and future development directions of combination therapy with aPDT and antibiotics, aiming to provide guidance for clinical application.- 收稿日期:2024-08-21;修回日期:2024-10-25 基金项目:河北省自然科学基金资助项目(B2022201097);保定市科技计划项目(2494F002);国家级大学生创新基金项目(DC2024281) 第一作者:王建国(1976—),男,河北大学附属医院主任技师,主要从事临床医学检验及诊断方向研究.E-mail:wangjianguo2007@163.com 通信作者:赵占娟(1974—),女,河北大学副教授,博士,主要从事激光医学方向研究.E-mail:zhaozhanjuanv@163.com 第3期王建国等:光动力抗菌疗法和抗生素联合应用对耐药菌感染的疗效及机制河北大学学报(自然科学版) 第45卷

Key words: aPDT, multidrug-resistant bacteria, antibiotic, combination therapy

CLC Number:

R378

WANG Jianguo, XIE Jiaxin, KONG Feiyan, LI Yutong, ZHAO Zhanjuan. Efficacy and mechanism of the combined application of photodynamic antibacterial therapy and antibiotic on drug-resistant bacterial infection[J]. Journal of Hebei University(Natural Science Edition), 2025, 45(3): 254-265.

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