Preparation of three-dimensional graphene/L-CysS composite modified electrode and its application in determination of clozapine

doi:10.3969/j.issn.1000-1565.2018.05.009

Abstract

Abstract: The 3DGR/L-CysS/GCE was prepared by drop-coating method, and characterized by electrochemical impedance spectroscopy(EIS)and scanning electron microscopy(SEM). The electrochemical behaviors of clozapine at 3DGR/L-CysS/GCE were studied by cyclic voltammetry(CV), controlled potential coulometry(CPC), differential pulse voltammetry(DPV)and chronocoulometry(CC). The experimental results showed that the reaction of clozapine at 3DGR/L-CysS/GCE was an electrochemical reaction with one electron and one proton transfer. The peak current and clozapine content showed a good linear relationship in the concentration range of 2.0×10^-5~5.0×10^-4 mol/L, and the detection limit was 1.21×10^-6 mol/L(S/N=3). 3DGR/L-CysS/GCE was used for the determination of clozapine in tablets, and the recovery was 97.5%~100.8%.

Key words: modified electrode, L-cystine, three-dimensional graphene, clozapine

CLC Number:

O657.1
R914

LIANG Ninggang, LI Juanjuan, CAI Zhuo, JIANG Cuiwen, YE Danni. Preparation of three-dimensional graphene/L-CysS composite modified electrode and its application in determination of clozapine[J]. Journal of Hebei University (Natural Science Edition), 2018, 38(5): 503-508.

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