Solvent-free Synthesis of 2-Aminothiazoles and 2-Methylthiazoles

doi:10.3969/j.issn.1000-1565.2010.01.012

Abstract

Abstract: A series of 2-aminothiazoles, 2-methylthiazoles were synthesized by the reaction of phenacyl halides, thioura or thioacetamide under solvent-free and catalyst-free conditions. The reactions were completed within 5-15 min giving the yields of 85%-98%, and the amount of thioura or thioacetamide was reduced to equivalent mole. The procedure offers several advantages including milder reaction conditions, easier work-up, shorter reaction time, and higher yields.

Key words: solvent-free, catalyst-free, 2-aminothiazoles, 2-methylthiazoles

CLC Number:

O621.3

WANG Shu-xiang,WU Qian-qian,DUAN Jie,GUO Shao-bo. Solvent-free Synthesis of 2-Aminothiazoles and 2-Methylthiazoles[J]. Journal of Hebei University (Natural Science Edition), 2010, 30(1): 53-57.

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