Renal clearance of a photothermal therapy agent based on quaterrylene-cyclodextrin conjugates

doi:10.3969/j.issn.1000-1565.2021.02.009

Journal of Hebei University(Natural Science Edition) ›› 2021, Vol. 41 ›› Issue (2): 166-170.DOI: 10.3969/j.issn.1000-1565.2021.02.009

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Renal clearance of a photothermal therapy agent based on quaterrylene-cyclodextrin conjugates

LI Jinmei¹, LUO Yali², WANG Kerang²

1. Department of Pathology, The First Central Hospital of Baoding, Baoding 071000, China; 2. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China

Received:2020-05-01 Online:2021-03-25 Published:2021-04-07

Abstract

Abstract: Photothermal therapy(PTT)is a promising avenue for precision cancer treatment. However, the metabolic clearance is a key issue for future clinical applications. In this paper, renal clearance of a cyclodextrin-modified quaterrylene bisimide derivative(QDI-CD)was studied. Importantly, QDI-CD administered to sprague-dawley(SD)rats by intraperitoneal injection was effectively cleared with renal clearance efficiency of(48.74 ± 11.80)% at 12 h after drug injection. In addition, the structure of QDI-CD in urines did not changed under the metabolism.

Key words: photothermal therapy, metabolic clearance, cyclodextrin, quaterrylene

CLC Number:

R73-37
R962

LI Jinmei, LUO Yali, WANG Kerang. Renal clearance of a photothermal therapy agent based on quaterrylene-cyclodextrin conjugates[J]. Journal of Hebei University(Natural Science Edition), 2021, 41(2): 166-170.

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Renal clearance of a photothermal therapy agent based on quaterrylene-cyclodextrin conjugates

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