A method for the determination of vancomycin and quinolones residues in chicken was developed using liquid chromatography mass spectrometry(LC-MS).The sample was extracted with acetonitrile and purified using MSPE as the sorbent.The target compounds were separated on a Agilent ZORBAX SB-C18 column(3.0 mm×100 mm,1.8 μm)before submitting for detection by high-resolution mass spectrometry.The results showed that high correlation coefficients(r2>0.99)of the analyses were obtained within their respective linear ranges.The average recoveries and the relative standard deviations ranged from 71.2% to 98.8% and 6.8% to 14.3% respectively at the spiked levels of 5,10,25 μg/kg in chicken.This method is reliable,and suitable for the determination of vancomycin and quinolones residues in chicken.
DONG Yanli
,
LIU Huimin
,
LI Chao
,
MA Jingjun
,
CUI Xiaona
. Determination of vancomycin and QNs residues in chicken by graphene based-MSPE-liquid chromatography-high-resolution mass spectrometry[J]. Journal of Hebei University(Natural Science Edition), 2016
, 36(5)
: 480
-486
.
DOI: 10.3969/j.issn.1000-1565.2016.05.006
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