To compare the active ingredients and pharmacological activities of ordinary Panax notoginseng powder and freeze-dried P. notoginseng powder. The differences of active ingredients between the ordinary and the freeze-dried P. notoginseng powder were determined by observing the particle size of ordinary powder and freeze-dried P. notoginseng powder under the microscope, visually observing the solubility of the suspension and detecting the active ingredient content by HPLC. The differences of pharmacological effects between ordinary powder and freeze-dried P. notoginseng powder were determined by capillary tube method, tail-cut method, xylene-induced ear swelling test and organ index. The results showed that these two P. notoginseng powders were different in the particle size, solubility and active ingredient content;ordinary powder had strong effect on blood coagulation and lyophilized powder exhibited anti-inflammatory effect;- DOI:10.3969/j.issn.1000-1565.2020.03.007普通和冻干三七粉的有效成分及药理作用比较张君,孙思勉,赵琳,周航,林冬菊,霍小位 (河北大学 药学院,河北省药物质量分析控制重点实验室,河北 保定 071002)摘 要:为比较普通三七Panax notoginseng粉和冻干三七粉的有效成分及药理活性,通过在显微镜下观察普通三七粉和冻干三七粉的粒径,肉眼观察其混悬液的溶解度,HPLC法检测有效成分含量来明确普通三七粉和冻干三七粉在有效成分方面的区别.通过毛细玻管法、剪尾法、二甲苯所致小鼠耳肿胀实验和器官指数等实验研究普通三七粉和冻干三七粉在药理作用方面的差异.研究结果表明:2种三七粉的粒径、溶解度、有效成分含量存在差异.普通粉高剂量组有一定的凝血作用;冻干粉高剂量组有一定的抗炎作用,2者对免疫器官均无明显影响.关键词:三七;冻干粉;普通粉;有效成分;药理作用中图分类号:R96;R917 文献标志码:A 【additional_page=282】文章编号:1000-1565(2020)03-0269-07Comparative evaluation of the active ingredients and pharmacological activities of ordinary P. notoginseng powder and lyophilized P. notoginseng powderZHANG Jun, SUN Simian, ZHAO Lin, ZHOU Hang, LIN Dongju, HUO Xiaowei(Key Laboratory of Pharmaceutical Quality Control of Hebei Province,College of Pharmaceutical Science, Hebei University, Baoding 071002, China)Abstract: To compare the active ingredients and pharmacological activities of ordinary Panax notoginseng powder and freeze-dried P. notoginseng powder. The differences of active ingredients between the ordinary and the freeze-dried P. notoginseng powder were determined by observing the particle size of ordinary powder and freeze-dried P. notoginseng powder under the microscope, visually observing the solubility of the suspension and detecting the active ingredient content by HPLC. The differences of pharmacological effects between ordinary powder and freeze-dried P. notoginseng powder were determined by capillary tube method, tail-cut method, xylene-induced ear swelling test and organ index. The results showed that these two P. notoginseng powders were different in the particle size, solubility and active ingredient content;ordinary powder had strong effect on blood coagulation and lyophilized powder exhibited anti-inflammatory effect;- 收稿日期:2019-07-20 基金项目:河北省教育厅资助项目(QN2018153);河北大学大学生创新创业训练计划项目(2018116,2018111);河北大学研究生创新项目(hbu2019ss082) 第一作者:张君(1993—),女,河北保定人,河北大学在读硕士研究生,主要从事药理学方向的研究.E-mail:zhangjun696@126.com 通信作者:霍小位(1988—),女,山东滨州人,河北大学讲师,主要从事药理学方向的研究.E-mail:huoxiaoweiforever@163.com林冬菊(1987—),女,黑龙江哈尔滨人,河北大学讲师,主要从事药物分析方向的研究.E-mail:lindo.ngju@163.com第3期张君等:普通和冻干三七粉的有效成分及药理作用比较they both had no significant effect on immune organs.
ZHANG Jun
,
SUN Simian
,
ZHAO Lin
,
ZHOU Hang
,
LIN Dongju
,
HUO Xiaowei
. Comparative evaluation of the active ingredients and pharmacological activities of ordinary P. notoginseng powder and lyophilized P. notoginseng powder[J]. Journal of Hebei University(Natural Science Edition), 2020
, 40(3)
: 269
-275
.
DOI: 10.3969/j.issn.1000-1565.2020.03.007
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