Table of Content

25 March 2023, Volume 43 Issue 2

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Uncertain linguistic generalized weighted Heronian mean operator and its application in decision making

HU Ximei, YANG Shuxia, TIAN Dazeng

2023, 43(2):  113-120.  DOI: 10.3969/j.issn.1000-1565.2023.02.001

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In practical multiple-attribute decision making problems, sometimes there are correlations between attributes, and attribute values are given in the form of uncertain language. In order to solve the multiple-attribute decision making problems with correlations between attributes in uncertain linguistic environment, the uncertain linguistic generalized weighted Heronian mean(ULGWHM)operator is given, and its properties are studied, including idempotency, boundedness, monotonicity, permutation and limit properties. Then a multiple-attribute decision making method based on this operator is presented. Finally, the feasibility of multiple-attribute decision making method based on ULGWHM operator is illustrated by an example.

Strong radius and strong diameter of strong product of complete graphs

LIU Shuyang,LI Feng,YIN Haoran

2023, 43(2):  121-126.  DOI: 10.3969/j.issn.1000-1565.2023.02.002

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It is proved that the strong product of two non-trivial complete graphs is a complete graph and has strong orientation. And then the exact values of the minimum strong radius and the minimum strong diameter of the strong product of the complete graph are determined, and the ranges of the maximum strong diameter and the maximum strong radius are also given. Besides, the above conclusion is extended to strong products of multiple complete graphs.

Orders and types of harmonic entire mappings

QIAO Jinjing, TIAN Yue, ZHENG Lifang

2023, 43(2):  127-132.  DOI: 10.3969/j.issn.1000-1565.2023.02.003

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In order to discuss the growth estimates of harmonic entire mappings, the order and the type of harmonic entire mappings are studied, and they can be characterized by the coefficients of the analytic parts and anti-analytic parts. For a strictly increasing sequence of positive integers{n_k}^∞_k=1, two quantities are defined by using the values of n_k order derivative of the analytic part and anti-analytic part of a harmonic entire mapping at a certain point, and it is proved that these two quantities are equal to the order and the type of the harmonic entire mapping, respectively, almost everywhere.

Distribution of dusty plasma particles on an asymmetrical electrode

ZHANG Shunxin, WANG Shuo, ZHANG Ning, CAI Yawen, HE Yafeng

2023, 43(2):  133-138.  DOI: 10.3969/j.issn.1000-1565.2023.02.004

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For RF(radio frequency, RF)glow discharge with asymmetric electrode, the distributions of parameters such as the sheath potential and the electron density near the asymmetrical electrode are studied by using a two-dimensional dusty plasma sheath model, and the forces acting on dust particles in the sheath are analyzed to study the distribution characteristics of dust particles in the sheath. Results show that the potential near the sheath of the electrode has the characteristics of ratchet potential. The dust particles are suspended in the sheath by the electric field of the sheath, and the potential at the balance position of dust particles exhibits asymmetrical and periodical change. By comparing the results with different sizes of particles, it is found that the small dust particles are suspended at the higher position in the sheath to form a chain, however, the large dust particles are close to the electrode and are "pinned" to the potential well generated by the asymmetric electrode.

Heavy neutrino decays in left-right symmetric model

QIN Renhui, HE Linyun, NING Guozhu

2023, 43(2):  139-145.  DOI: 10.3969/j.issn.1000-1565.2023.02.005

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In left-right symmetric model, various kinds of decay channels of heavy neutrino are evaluated when its mass is lighter than the mass of left handed gauge boson W_L. It is found that the total decay rate of heavy neutrino can be classified into left part dominance, right part dominance, and coexistence of left and right part. The results shows that when the heavy-light neutrino mixings is equaled to 1 and the mass of right handed gauge boson W_R is taken to be the lightest one satisfied by experiments, the total decay rate of heavy neutrino is still far smaller than its mass.

Effects of Hofmeister series anions and cations on the amyloid fibrillation of lysozyme

LI Yan, CAO Siyu, MA Gang

2023, 43(2):  146-155.  DOI: 10.3969/j.issn.1000-1565.2023.02.006

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In this work, the effects of nine Hofmeister series anions(SO₄^2- >F^- >COO^->Cl^->Br^->NO₃^->I^->ClO₄^->SCN^-)and nine Hofmeister cations(NH₄⁺>K⁺>Na⁺>Cs⁺>Li⁺>Rb⁺>Mg²⁺>Ca²⁺ >Ba²⁺)on the amyloid fibrillation of lysozyme were studied using atomic force microscopy(AFM)and Fourier transform infrared(FTIR)spectroscopy. The AFM results indicated that anions at different locations in the Hofmeister series had different impacts on the morphologies of lysozyme amyloid fibril. Under the influences of the three kosmotropic anions of SO₄^2-, F^-, COO^-, the morphology of fibril displayed branching and thickening; while under the influences of the other chaotropic anions of Cl^-, Br^-, NO₃^-, I^-, ClO₄^-, SCN^- displayed the common long and thin morphologies. This phenomenon was attributed to the difference impacts of the two different types of anions on the secondary nucleation of lysozyme amyloid fibrillation. In contrast to the effects of anions, different cations showed similar effects- DOI:10.3969/j.issn.1000-1565.2023.02.006Hofmeister序列阴阳离子对溶菌酶淀粉样纤维的影响李妍, 曹思雨,马刚(河北大学 化学与材料科学学院,河北 保定 071002)摘 要:应用原子力显微镜(AFM)技术和傅里叶变换红外光谱(FTIR)技术对Hofmeister阴阳离子序列中9种阴离子(SO₄^2->F^->COO^->Cl^->Br^->NO₃^->I^->ClO₄^->SCN^-)和9种阳离子(NH₄⁺>K⁺>Na⁺>Cs⁺>Li⁺>Rb⁺>Mg²⁺>Ca²⁺>Ba²⁺)对溶菌酶淀粉样纤维化的影响进行了研究.通过AFM技术研究,发现Hofmeister序列中不同位置的阴离子对溶菌酶淀粉样纤维的微观形貌存在不同的影响,其中受SO₄^2-、F^-、COO^-这3种亲水阴离子影响生成的纤维呈现纤维分枝和增厚的现象,而受Cl^-、Br^-、NO₃^-、I^-、ClO₄^-、SCN^-这6种疏水阴离子影响的纤维则为常见的细长纤维.本研究将出现这种现象的原因归因于这2类阴离子对溶菌酶淀粉样纤维化二次成核过程的影响差异.与阴离子效应相反,研究中发现9种Hofmeister序列阳离子对溶菌酶淀粉样纤维的形貌影响差异不大.利用红外光谱分峰拟合技术,探究了不同阴阳离子影响下生成的淀粉样纤维中各种二级结构含量由多到少的排序与Hofmeister序列的相关性.希望本工作中的这些新发现能为人们更加深入地理解淀粉样纤维化的影响因素提供有益参考.关键词:淀粉样纤维化;溶菌酶;Hofmeister序列;傅里叶变换红外光谱;原子力显微镜中图分类号:O643 文献标志码:A 文章编号:1000-1565(2023)02-0146-10Effects of Hofmeister series anions and cations on the amyloid fibrillation of lysozymeLI Yan, CAO Siyu, MA Gang(College of Chemistry and Materials Science, Hebei University, Baoding 071002, China)Abstract: In this work, the effects of nine Hofmeister series anions(SO₄^2- >F^- >COO^->Cl^->Br^->NO₃^->I^->ClO₄^->SCN^-)and nine Hofmeister cations(NH₄⁺>K⁺>Na⁺>Cs⁺>Li⁺>Rb⁺>Mg²⁺>Ca²⁺ >Ba²⁺)on the amyloid fibrillation of lysozyme were studied using atomic force microscopy(AFM)and Fourier transform infrared(FTIR)spectroscopy. The AFM results indicated that anions at different locations in the Hofmeister series had different impacts on the morphologies of lysozyme amyloid fibril. Under the influences of the three kosmotropic anions of SO₄^2-, F^-, COO^-, the morphology of fibril displayed branching and thickening; while under the influences of the other chaotropic anions of Cl^-, Br^-, NO₃^-, I^-, ClO₄^-, SCN^- displayed the common long and thin morphologies. This phenomenon was attributed to the difference impacts of the two different types of anions on the secondary nucleation of lysozyme amyloid fibrillation. In contrast to the effects of anions, different cations showed similar effects- 收稿日期:2022-12-10 基金项目:国家自然科学基金资助项目(21973024) 第一作者:李妍(1978—),女,河北邯郸人,河北大学在读博士研究生,主要从事淀粉样纤维化方向的研究.E-mail:yanli0390@sina.com 通信作者:马刚(1971—),男,北京人,河北大学教授,主要从事淀粉样纤维化方向的研究.E-mail:gangma@hbu.edu.cn第2期李妍等:Hofmeister序列阴阳离子对溶菌酶淀粉样纤维的影响河北大学学报(自然科学版) 第43卷on the morphologies of the amyloid fibrillation of lysozyme. Using FTIR curve-fitting technique, the correlation between the orders of anions and cations in the Hofmeister series and the orders of the contents of various secondary structures in lysozyme amyloid fibrils was also explored. It is hoped that the new findings in this work are beneficial for deeper understanding of different factors that affect amyloid fibrillation.

Study on the mechanism of mannuronic acid oligosaccharide sensitizing ciprofloxacin against Escherichia coli

XIE Xiaoying, GUO Huaizhong, CAO Lijun, MA Mengnan, CUI Xiuyan

2023, 43(2):  156-162.  DOI: 10.3969/j.issn.1000-1565.2023.02.007

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By investigating the content of ciprofloxacin(CPFX)in Escherichia coli and the effect of mannuronic acid oligosaccharide(MOS)with different concentrations on the inhibitory activity of CPFX against E.coli, the mechanism that MOS sensitize the inhibitory activity of CPFX against E.coli was explored. CPFX and MOS with different concentrations were added into the bacterial suspension and cultured for 150 min at 37 ℃ to observe the bacteriostatic effect. The content of CPFX in the bacteria was determined by HPLC, and the fluorescence intensity of CPFX in the bacteria was observed by confocal laser scanning microscope(CLSM)to verify the above result. The effect of Ca²⁺ on the elevated antimicrobial effect of CPFX with MOS was also investigated. The results showed that when CPFX was- DOI:10.3969/j.issn.1000-1565.2023.02.007甘露糖醛酸寡糖增敏环丙沙星抑制大肠埃希菌机制的研究 谢笑莹¹,郭怀忠^1,2,曹丽军³,马梦楠¹,崔秀彦⁴(1.河北大学 药学院,河北 保定 071002;2.河北省药物质量分析控制重点实验室,河北 保定 071002;3.河北大学附属医院 检验科,河北 保定 071000;4.河北大学附属医院 药学部,河北 保定 071000)摘 要:通过考察大肠埃希菌(Escherichia.coli)体内环丙沙星(ciprofloxacin, CPFX)的含量以及联用不同浓度甘露糖醛酸寡糖(MOS)对CPFX抑制E.coli效果的影响,探讨了MOS增敏CPFX抑制E.coli活性的作用机制.在菌液中加入CPFX和不同质量浓度的MOS,37 ℃培养150 min,观察抑菌效果,并用HPLC法测定E.coli体内CPFX的含量,同时通过激光扫描共聚焦显微镜(CLSM)观察E.coli体内CPFX的荧光强度进行验证.还考察了Ca²⁺对MOS增敏CPFX抑菌效果的影响.结果显示:CPFX与高浓度的MOS联用时,E.coli体内CPFX的含量较低;与较低浓度的MOS联用时,E.coli体内CPFX的含量较高,与其抑菌实验联用MOS高浓度时拮抗,低浓度时增敏的结果一致.Ca²⁺的加入,在一定程度上逆转了高浓度MOS与CPFX的拮抗作用.该研究可为新型抗菌增效剂的开发和抗耐药菌感染的临床应用提供参考.关键词:甘露糖醛酸寡糖;环丙沙星;大肠埃希菌;Ca²⁺中图分类号:R917 文献标志码:A 文章编号:1000-1565(2023)02-0156-07Study on the mechanism of mannuronic acid oligosaccharidesensitizing ciprofloxacin against Escherichia coliXIE Xiaoying¹, GUO Huaizhong^1,2, CAO Lijun³, MA Mengnan¹, CUI Xiuyan⁴(1. College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China; 2. Key Laboratoryof Pharmaceutical Quality Analysis and Control of Hebei Province, Baoding 071002, China; 3. Department of Clinical Laboratory, Affiliated Hospital of Hebei University, Baoding 071000, China;4.Department of Pharmacy,Affiliated Hospital of Hebei University,Baoding 071000,China)Abstract: By investigating the content of ciprofloxacin(CPFX)in Escherichia coli and the effect of mannuronic acid oligosaccharide(MOS)with different concentrations on the inhibitory activity of CPFX against E.coli, the mechanism that MOS sensitize the inhibitory activity of CPFX against E.coli was explored. CPFX and MOS with different concentrations were added into the bacterial suspension and cultured for 150 min at 37 ℃ to observe the bacteriostatic effect. The content of CPFX in the bacteria was determined by HPLC, and the fluorescence intensity of CPFX in the bacteria was observed by confocal laser scanning microscope(CLSM)to verify the above result. The effect of Ca²⁺ on the elevated antimicrobial effect of CPFX with MOS was also investigated. The results showed that when CPFX was- 收稿日期:2022-04-25 基金项目:河北省自然科学基金资助项目(H2021201018,H2016201221);河北省创新能力提升计划(20567605H) 第一作者:谢笑莹(1995—),女,河南商丘人,河北大学在读硕士研究生.E-mail:792270064@qq.com 通信作者:郭怀忠(1968—),男,内蒙古商都人,河北大学教授,博士,主要从事中药质量控制及其药效学研究.E-mail:ghuaizh@aliyun.com第2期谢笑莹等:甘露糖醛酸寡糖增敏环丙沙星抑制大肠埃希菌机制的研究河北大学学报(自然科学版) 第43卷combined with MOS of higher concentration, the content of CPFX in E.coli was lower, however, when with MOS of a lower concentration, the content of CPFX in E.coli was higher. The antagonistic results were consistent with the inhibitory results when MOS was combined under high concentration in the bacteriostatic experiment. The addition of Ca²⁺ reversed the antagonism between high concentration of MOS and CPFX to a certain extent. This study can provide reference for the development of new antimicrobial synergist and clinical application of anti-drug resistant bacteria infection.

Determination of common hypnotic and sedutive drugs in whole blood by UPLC-MS/MS

FANG Yali, MA Ji

2023, 43(2):  163-170.  DOI: 10.3969/j.issn.1000-1565.2023.02.008

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A high throughput screening method based on ultra performance liquid chromatogramphy-triple quadrupole composite linear ion trap mass spectrometry(UPLC-Q-TRAP/MS)was developed for the simultaneous and rapid confirmation of 49 common hypnotic and sedutive drugs. The pre-treatment method was based on solid-supported liquid liquid extraction(SLE). Waters C18 chromatographic column(2.1 mm×50 mm, 1.7 μm)was selected, with 0.1%(V/V)formic acid,5 mmoL/L ammonium acetate aqueous solution and methanol as mobile phases for gradient elution. The calibration curves showed good linearity in the range of 0.1~200.0 ng/mL,with correlation coefficients(R²)greater than 0.99 for all 49 analytes. The limits of highest detection and highest quantification of the 49 compounds were 0.1 ng/mL and 0.5 ng/mL, respectively. At spiked levels of 50、100、200 ng/mL, recoveries, intra-day precisions, and inter-day precisions of the 49 compounds were 65.9%~109.0%, 2.0%~17.6%, and 2.0%~16.3%, respectively. The established method is suitable for screening and testing these compounds in biological samples.- DOI:10.3969/j.issn.1000-1565.2023.02.008超高效液相色谱-三重四极杆串联质谱法检测全血中常见安眠镇静类药物方雅莉¹,马骥²(1.广东医科大学 科研平台服务管理中心,广东 东莞 523000;2.东莞市公安局 物证鉴定中心,广东 东莞 523000)摘 要:建立了超高效液相色谱-三重四极杆复合线性离子阱质谱快速筛查确证全血中49种安眠镇静类药物. 样品前处理采用固相支撑液液萃取法. 色谱条件:色谱柱为Waters C18(2.1 mm×50 mm,1.7 μm),以5 mmol/L乙酸铵-(体积分数为0.1%)甲酸水溶液(A),甲醇(B)为流动相,进行梯度洗脱. 在0.1~200.0 ng/mL内,49种常见药物展现出良好的线性关系(R²>0.99),最高检出限为0.1 ng/mL;最高定量限为0.5 ng/mL;全血基质中50、100、200 ng/mL 3个加标水平下回收率为65.9%~109.0%,日内精密度为2.0%~17.6%、日间精密度为2.0%~16.3%. 该方法可应用于生物检材中49种常见安眠镇静物质的检测.关键词:安眠镇静类药物;超高效液相色谱串联质谱;全血中图分类号:O657.7 文献标志码:A 文章编号:1000-1565(2023)02-0163-08Determination of common hypnotic and sedutive drugs in whole blood by UPLC-MS/MSFANG Yali¹, MA Ji²(1. Scientific Research Platform Service Management Center, Guangdong Medical University, Dongguan 523000, China; 2. Forensic Science Center, Dongguan Public Security Department, Dongguan 523000, China)Abstract: A high throughput screening method based on ultra performance liquid chromatogramphy-triple quadrupole composite linear ion trap mass spectrometry(UPLC-Q-TRAP/MS)was developed for the simultaneous and rapid confirmation of 49 common hypnotic and sedutive drugs. The pre-treatment method was based on solid-supported liquid liquid extraction(SLE). Waters C18 chromatographic column(2.1 mm×50 mm, 1.7 μm)was selected, with 0.1%(V/V)formic acid,5 mmoL/L ammonium acetate aqueous solution and methanol as mobile phases for gradient elution. The calibration curves showed good linearity in the range of 0.1~200.0 ng/mL,with correlation coefficients(R²)greater than 0.99 for all 49 analytes. The limits of highest detection and highest quantification of the 49 compounds were 0.1 ng/mL and 0.5 ng/mL, respectively. At spiked levels of 50、100、200 ng/mL, recoveries, intra-day precisions, and inter-day precisions of the 49 compounds were 65.9%~109.0%, 2.0%~17.6%, and 2.0%~16.3%, respectively. The established method is suitable for screening and testing these compounds in biological samples.- 收稿日期:2022-06-11 基金项目:广东医科大学青年培育基金自然科学类面上项目(GDMUQ2021050);广东省公安厅科技攻关项目(2022GDSSGG15;2022GDSSGG16) 第一作者:方雅莉(1991—),女,湖南岳阳人,广东医科大学实验师,主要从事化学分析和化学合成研究.E-mail:872173777@qq.com第2期方雅莉等:超高效液相色谱-三重四极杆串联质谱法检测全血中常见安眠镇静类药物河北大学学报(自然科学版) 第43卷

Comparison of application of assemblers in phylogenomics

WANG Yaozhuo, ZHANG Wenqiang, ZHANG Junxia

2023, 43(2):  171-178.  DOI: 10.3969/j.issn.1000-1565.2023.02.009

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To select the most suitable assembler for ultra-conserved elements(UCE)phylogenomic practice, five different assembly softwares, SPAdes, ABySS, Velvet, Trinity and Minia were applied, to assemble 17 UCE captured sequencing libraries, respectively. The results showed that among the five assemblers, Trinity consumed significantly longer computational time than the others; SPAdes and Trinity both assembled more contigs and obtained more longer contigs(> 250 bp)than the other three assemblers, but SPAdes captured the highest number of UCE loci. Therefore, SPAdes is more suitable for the assembly of UCE data than the other assembly softwares. This study provides a technical reference for the practice of UCE-based phylogenomic studies.

miR-194-5p inhibits activation of human hepatic stellate cells through Wnt5a

LI Yaqi, ZHANG Ronghua, LIU Yutan, CAO Yumeng, XIONG Yanan, ZHANG Guangling

2023, 43(2):  179-187.  DOI: 10.3969/j.issn.1000-1565.2023.02.010

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To investigate the effects and mechanism of miR-194-5p on the activation of hepatic stellate cells(HSCs), CCK-8, β-galactosidase staining, Transwell, wound healing, colony formation assays, RT-qPCR and Western blot were used to detect the effects of miR-194-5p on the cell biological properties, the expression of HSC activation markers and target gene, respectively. The candidate target genes of miR-194-5p were confirmed by the bioinformatics website and dual luciferase reporter assay. The results showed that the proliferation, cell colony formation, migration ability and HSC activation markers expression of LX-2 cells were inhibited by miR-194-5p; the senescence was promoted by miR-194-5p; and- DOI:10.3969/j.issn.1000-1565.2023.02.010miR-194-5p通过Wnt5a抑制肝星状细胞活化李亚琦¹,张荣花¹,刘雨潭¹,曹雨萌¹,熊亚南¹,章广玲²(1.华北理工大学 基础医学院, 河北省慢性疾病重点实验室, 河北 唐山 063200;2.华北理工大学 临床医学院,河北省医工融合精准医疗重点实验室, 河北 唐山 063200)摘 要:为研究miR-194-5p对肝星状细胞(HSCs)活化的影响及作用机制,采用CCK-8、β-半乳糖苷酶染色、Transwell、划痕、集落形成实验和RT-qPCR、Western blot分别检测miR-194-5p 对LX-2细胞生物学特性、细胞活化标志物和靶基因表达的影响,并用生物信息学和双荧光素酶报告实验确定miR-194-5p靶基因. 结果显示:miR-194-5p抑制LX-2细胞增殖、细胞集落形成、迁移能力以及LX-2细胞中活化标志物的表达,促进LX-2细胞衰老;Wnt5a为miR-194-5p的直接靶基因.研究表明miR-194-5p通过靶定Wnt5a抑制LX-2细胞活化,miR-194-5p和Wnt5a可能是治疗肝纤维化新的靶点.关键词:miR-194-5p;肝纤维化;肝星状细胞活化;增殖;迁移中图分类号:R575.2 文献标志码:A 文章编号:1000-1565(2023)02-0179-09miR-194-5p inhibits activation of human hepatic stellate cells through Wnt5aLI Yaqi¹, ZHANG Ronghua¹, LIU Yutan¹, CAO Yumeng¹, XIONG Yanan¹, ZHANG Guangling²(1.Hebei Key Laboratory for Chronic Diseases, School of Basic Medicine, North China University of Science and Technology, Tangshan 063200, China; 2. Hebei Provincial Key Laboratory of Medical-Industrial Integration Precision Medicine, School of Clinical Medicine, North China University of Science and Technology, Tangshan 063200, China)Abstract: To investigate the effects and mechanism of miR-194-5p on the activation of hepatic stellate cells(HSCs), CCK-8, β-galactosidase staining, Transwell, wound healing, colony formation assays, RT-qPCR and Western blot were used to detect the effects of miR-194-5p on the cell biological properties, the expression of HSC activation markers and target gene, respectively. The candidate target genes of miR-194-5p were confirmed by the bioinformatics website and dual luciferase reporter assay. The results showed that the proliferation, cell colony formation, migration ability and HSC activation markers expression of LX-2 cells were inhibited by miR-194-5p; the senescence was promoted by miR-194-5p; and- 收稿日期:2022-06-07 基金项目:河北省自然科学基金资助项目(H2021209026);河北省人力资源和社会保障厅项目(C20210340);2020年政府资助临床医学优秀人才培养项目(冀财预付［2020］397号) 第一作者:李亚琦(1997—),女,河北邯郸人,华北理工大学在读硕士研究生,主要从事肝纤维化分子机制方向研究. E-mail:871528007@qq.com 通信作者:熊亚南(1978—),女,河北唐山人,华北理工大学副教授,主要从事肝纤维化分子机制方向研究.E-mail:xiongyanan@ncst.edu.cn章广玲(1972—),女,河北唐山人,华北理工大学教授,博士,主要从事肝纤维化分子机制方向研究.E-mail:zhanggl@ncst.edu.cn第2期李亚琦等:miR-194-5p通过Wnt5a抑制肝星状细胞活化河北大学学报(自然科学版) 第43卷Wnt5a was a target gene of miR-194-5p. Our findings provide evidence that miR-194-5p inhibits LX-2 cell activation by targeting Wnt5a. Therefore, miR-194-5p and Wnt5a may be possible novel therapeutic targets for hepatic fibrosis.

Application and mechanism of photodynamic therapy in the treatment of diabetic foot

ZHAO Jianxi, PANG Jingwen, TIAN Xiang, YAN Xinghan, ZHANG Zhiming, ZHAO Zhanjuan

2023, 43(2):  188-196.  DOI: 10.3969/j.issn.1000-1565.2023.02.011

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Diabetic foot is a foot tissue destruction unrelated to other traumatic factors and caused by diabetes, and is clinically chronic wound, often complicated by ischemia, peripheral neuropathy and infection; impaired healing increases the likelihood of infection, so anti-infective therapy is a key to the treatment of diabetic foot. At present, antibiotics are mostly used for anti-infection treatment in clinical practice, but the pathophysiological changes of diabetic foot hinder the penetration of antibiotics in ulcers, which cause difficulty in reaching the lesion site, and at the same time, antibiotic multidrug resistance also increases the difficulty of treatment of diabetic foot. Photodynamic therapy provides new options for the treatment of diabetic foot with its advantages of good targeting, low side effects, and no resistance to microorganisms. In recent years, photodynamic therapy has made good progress in the treatment of diabetic foot. Therefore, this article elaborates the application, therapeutic mechanism- DOI:10.3969/j.issn.1000-1565.2023.02.011光动力疗法在糖尿病足治疗中的应用及机制赵建喜¹,庞静文²,田翔²,闫星寒³,张秩铭³, 赵占娟³(1.河北大学附属医院 放射科,河北 保定 071002; 2.河北大学 临床医学院,河北 保定 071002; 3.河北大学 基础医学院,河北 保定 071002)摘 要:糖尿病足是糖尿病导致的与其他外伤因素等无关的足部组织破坏,在临床上属于慢性伤口,常合并缺血、周围神经病变以及感染,其愈合受损增加了感染的可能,因此在糖尿病足的治疗过程中,抗感染治疗是关键.目前临床上多使用抗生素进行抗感染治疗,但糖尿病足的病理生理变化阻碍了抗生素在溃疡中的渗透,使其难以到达病变部位,同时,由于抗生素多重耐药现象逐渐严峻,也增加了糖尿病足的治疗难度.光动力疗法以其靶向性好、副作用低、对微生物无耐药性等优点给糖尿病足的医治提供了新的选择.近年来,光动力疗法在治疗糖尿病足方面取得了不错的进展.因此,本文对光动力疗法在糖尿病足中的应用、治疗机制、近期的研究成果等方面进行阐述.关键词:光动力疗法;糖尿病足;光敏剂;抗生素耐药中图分类号:Q81;R4 文献标志码:A 文章编号:1000-1565(2023)02-0188-09Application and mechanism of photodynamic therapy in the treatment of diabetic footZHAO Jianxi¹, PANG Jingwen², TIAN Xiang², YAN Xinghan³, ZHANG Zhiming³, ZHAO Zhanjuan³(1. Department of Radiology, Affiliated Hospital of Hebei University, Baoding 071002,China; 2.School of Clinical Medicine, Hebei University, Baoding 071002,China; 3.School of Basic Medicine, Hebei University, Baoding 071002,China)Abstract: Diabetic foot is a foot tissue destruction unrelated to other traumatic factors and caused by diabetes, and is clinically chronic wound, often complicated by ischemia, peripheral neuropathy and infection; impaired healing increases the likelihood of infection, so anti-infective therapy is a key to the treatment of diabetic foot. At present, antibiotics are mostly used for anti-infection treatment in clinical practice, but the pathophysiological changes of diabetic foot hinder the penetration of antibiotics in ulcers, which cause difficulty in reaching the lesion site, and at the same time, antibiotic multidrug resistance also increases the difficulty of treatment of diabetic foot. Photodynamic therapy provides new options for the treatment of diabetic foot with its advantages of good targeting, low side effects, and no resistance to microorganisms. In recent years, photodynamic therapy has made good progress in the treatment of diabetic foot. Therefore, this article elaborates the application, therapeutic mechanism- 收稿日期:2022-06-07 基金项目:河北省自然科学基金资助项目(B2022201097);河北省医学科学研究课题计划项目(20220034);大学生创新创业训练计划项目(2022376);保定市科技计划项目(2172P002) 第一作者:赵建喜(1966—),男,河北保定人,河北大学附属医院主任医师,主要从事放射医学研究. E-mail:jianxizhaov@163.com 通信作者:赵占娟(1974—),女,河北保定人,河北大学副教授,博士,主要从事激光医学研究. E-mail:zhaozhanjuanv@163.com第2期赵建喜等:光动力疗法在糖尿病足治疗中的应用及机制河北大学学报(自然科学版) 第43卷and research results and so on in the treatment of photodynamic therapy in diabetic foot.

Ecological environment quality evaluation and driving factor analysis of Wuan national forest park in Hebei province

SU Yujiao, ZHANG Peng, ZHANG Xiaohua, ZHAO Yanli, LI Liangtao

2023, 43(2):  197-206.  DOI: 10.3969/j.issn.1000-1565.2023.02.012

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To understand the change in ecological environment quality and driving forces of Hebei Wuan national forest park, remote sensing data of the years 2005, 2013, and 2021 were utilized to investigate land use changes and ecological environment quality in the study area. Furthermore, the spatial distribution of POI density in the park in 2021 is discussed, and the geographic detector model is used to analyze the effects of elevation, slope, aspect, population density, POI density, greenness, wetness, dryness and heat based on the 2021 RSEI value is investigated, and the effects of relevant driving factor on- DOI:10.3969/j.issn.1000-1565.2023.02.012河北武安国家森林公园生态环境质量评价及驱动因子分析苏玉姣¹, 张鹏¹,张晓华²,赵艳丽²,李良涛¹(1. 河北工程大学 园林与生态工程学院,河北 邯郸 056000;2.武安林业局,河北 武安 056300)摘 要:为了解河北武安国家森林公园的生态环境质量变化及驱动因子,选择2005年、2013年和2021年3期遥感数据对研究区的土地利用变化及生态环境质量进行评价.此外,讨论了园内2021年POI密度的空间分布,并在2021年遥感生态指数(remote sensing ecological index, RSEI)的基础上,采用地理探测器模型分析园内高程、坡度、坡向、人口密度、POI密度、绿度、湿度、干度、热度对RSEI值的影响程度,并进一步探究相关驱动因子对RSEI模型中4项指标的影响程度.结果表明:1)2005—2013年,区域内生态环境质量出现“两级化”趋势,2013—2021年,西南区域的环境质量大幅提升,但生态质量较好的区域(主要位于自然保护区内)占比大幅下降;2)旅游开发较好的景区POI密度最高,旅游环线及重点乡镇的POI密度次之;3)绿度、湿度、干度、热度及高程对公园内RSEI值影响较强,而坡向、坡度及人口密度影响较弱,POI密度对RSEI值无显著影响;4)绿度、湿度对高程、坡度、坡向及人口密度较为敏感,干度和热度则不敏感.本研究成果可为国家森林公园生态环境管护优化提供依据.关键词:国家森林公园;生态环境质量;驱动因子;地理探测器模型中图分类号:S7 文献标志码:A 文章编号:1000-1565(2023)02-0197-10Ecological environment quality evaluation and driving factor analysis of Wuan national forest park in Hebei provinceSU Yujiao¹, ZHANG Peng¹, ZHANG Xiaohua², ZHAO Yanli², LI Liangtao¹(1.College of Landscape and Ecological Engineering,Hebei University of Engineering,Handan 056000,China;2.Wuan Forestry Bureau, Wuan 056300,China)Abstract: To understand the change in ecological environment quality and driving forces of Hebei Wuan national forest park, remote sensing data of the years 2005, 2013, and 2021 were utilized to investigate land use changes and ecological environment quality in the study area. Furthermore, the spatial distribution of POI density in the park in 2021 is discussed, and the geographic detector model is used to analyze the effects of elevation, slope, aspect, population density, POI density, greenness, wetness, dryness and heat based on the 2021 RSEI value is investigated, and the effects of relevant driving factor on- 收稿日期:2022-05-14 基金项目:河北省林业和草原科学技术研究项目(2001019);武安青崖寨国家级自然保护区建设项目(20180702);邯郸市科学技术研究与发展计划项目(1727201065) 第一作者: 苏玉姣(1994—), 女, 新疆阿克苏人,河北工程大学在读硕士研究生, 主要从事土地利用变化及生态环境评价研究.E-mail: 2506043414@qq.com 通信作者:李良涛(1978—), 男, 河北邯郸人, 河北工程大学副教授, 博士, 主要从事景观生态学研究.E-mail: liliangtao@hebeu.edu.cn第2期苏玉姣等:河北武安国家森林公园生态环境质量评价及驱动因子分析河北大学学报(自然科学版) 第43卷four indicators in the RSEI model were further explored. The results showed that: 1)From 2005 to 2013, the regions ecological environment quality displayed a “two-level” pattern; from 2013 to 2021, the southwest regions environmental quality grew dramatically, while the number of regions with greater ecological quality declined significantly, mostly in nature reserves;2)The POI density of scenic spots with better tourism development is the highest, followed by the POI density of tourist ring roads and key towns;3)Greenness, wetness, dryness, heat and elevation had strong effects on RSEI values of the park, whereas aspect, slope and population density have lower impact, POI density has no significant effect on RSEI value;4)While wetness and greenness are more sensitive to elevation, slope, aspect, and population density, dryness and heat are not. The findings of this study can be used to improve ecological environment management and protect national forest parks.

Improved TDOA 3d positioning algorithm based on adaptive Levy flight

WEI Zihui, LI Xiaoyang, WANG Le, CAI Daxin, YE Xingyue, DING Zhenjun

2023, 43(2):  207-215.  DOI: 10.3969/j.issn.1000-1565.2023.02.013

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Aiming at the problem that existing algorithms in the time difference of arrival(TDOA)measurement scheme show unbalanced search ability, leading to low positioning accuracy and even failure in solution in the part of the three-dimensional positioning area, a new approach based on improved approach is proposed. The TDOA positioning algorithm based on pathfinder algorithm(PFA)enhances the individual's adaptability to the complex environment of the positioning area by integrating the adaptive Levy flight and the improved PFA algorithm, and solves the problems of premature algorithm and easy localization, thus improving the comprehensive performance of the algorithm. Through simulation and experiments, the results show that compared with Taylor algorithm and LM algorithm, the algorithm proposed in this paper(Levy-pathfinder algorithm, LPFA)can improve the positioning accuracy; compared with PSO algorithm and PFA algorithm, LPFA algorithm can improve the operation speed and obtain more accurate positioning results.

Image denoising based on deep residual network with dual-domain information

LI Kai, ZHANG Hui, CUI Lijuan, PENG Jinjia, CHEN Taixi

2023, 43(2):  216-224.  DOI: 10.3969/j.issn.1000-1565.2023.02.014

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The denoising technology based on deep learning improves the image quality by considering visual artifacts and overall smoothing noise. However, they rarely involve the restoration of edge details. In this paper, a deep denoising network model based on dual-domain mapping and residual learning is proposed. The network learning information is extended by the fusion of wavelet domain information and spatial domain information. By introducing multi-scale learning and dilated convolution into the activation unit, the image features are extracted and the network parameters are reduced. In order to further improve the denoising results, the joint loss function of wavelet domain loss and spatial domain loss are combined to guide the network to obtain more edges and details. Experimental results show that the proposed method can not only effectively remove image noise, but also better restore image texture details, and obtain better results in both subjective and objective evaluation.