新型肝动脉栓塞微球制剂的制备

doi:10.3969/j.issn.1000-1565.2022.02.007

摘要/Abstract

摘要： 开发了一种适合肝动脉灌注化疗栓塞(TACE)用的姜黄素载药微球,并探究其对肝癌的治疗效果.以聚乙烯醇(PVA)为载体,采用乳液交联法制备微球,观察微球的外观和粒度,证明微球对癌细胞的抑制作用,在VX2兔模型中评估肝动脉栓塞微球治疗肝癌的功效.扫描电镜和粒度分析显示制备的微球球形完整;生物安全性证明微球材料安全指数较高;药效学研究表明姜黄素栓塞微球可在栓塞给药后有效发挥动脉栓塞作用,提高肝癌的治疗效果.本研究成功地制备了姜黄素栓塞微球,有望将其用于栓塞以提高TACE在肝癌中的治疗效果.

关键词: 肝细胞癌, 姜黄素, 微球, 肝动脉化疗栓塞

Abstract: To develop curcumin loaded microspheres suitable for transcatheter arterial chemoembolization(TACE)and to explore its therapeutic effect on liver cancer, microspheres were prepared with polyvinyl alcohol(PVA)as a carrier material by emulsification cross-linking method. The morphology and particle size distribution of the drug-loaded microspheres were evaluated. The inhibitory effects of microspheres on cancer cells were observed. We used VX2 liver cancer rabbit models to discuss the effectiveness of curcumin-loaded microspheres for hepatic artery embolization. Scanning electron microscope and particle size analysis showed that the microspheres had good sphericity. Safety testing determined that the safety index of microspheres was higher. The pharmacodynamic study showed that curcumin embolic microspheres could effectively play the role of arterial embolization after embolization administration and improve the therapeutic effect of liver cancer. Curcumin embolic microspheres had been successfully prepared in this study, which were expected to be used for embolization to improve the therapeutic efficiency- DOI:10.3969/j.issn.1000-1565.2022.02.007新型肝动脉栓塞微球制剂的制备宋鹏锦¹,韩啸¹,孙彩凤¹,孙海川²,曹晓亮³,胡连栋¹(1.河北大学河北省药物质量分析控制重点实验室,药学院,河北保定 071002;2.保定市第一中心医院医务处,河北保定 071000;3.保定市第一医院介入医学科,河北保定 071000)摘要:开发了一种适合肝动脉灌注化疗栓塞(TACE)用的姜黄素载药微球,并探究其对肝癌的治疗效果.以聚乙烯醇(PVA)为载体,采用乳液交联法制备微球,观察微球的外观和粒度,证明微球对癌细胞的抑制作用,在VX2兔模型中评估肝动脉栓塞微球治疗肝癌的功效.扫描电镜和粒度分析显示制备的微球球形完整;生物安全性证明微球材料安全指数较高;药效学研究表明姜黄素栓塞微球可在栓塞给药后有效发挥动脉栓塞作用,提高肝癌的治疗效果.本研究成功地制备了姜黄素栓塞微球,有望将其用于栓塞以提高TACE在肝癌中的治疗效果.关键词:肝细胞癌;姜黄素;微球;肝动脉化疗栓塞中图分类号:R944 文献标志码:A 文章编号:1000-1565(2022)02-0150-08Preparation of novel microsphere for hepatic arterial embolismSONG Pengjin¹, HAN Xiao¹, SUN Caifeng¹, SUN Haichuan², CAO Xiaoliang³, HU Liandong¹(1. College of Pharmacy, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China; 2. Medical Affair Department, Baoding First Central Hospital, Baoding 071000, China;3. Intervention Therapy Department, Baoding No. 1 Hospital, Baoding 071000, China)Abstract: To develop curcumin loaded microspheres suitable for transcatheter arterial chemoembolization(TACE)and to explore its therapeutic effect on liver cancer, microspheres were prepared with polyvinyl alcohol(PVA)as a carrier material by emulsification cross-linking method. The morphology and particle size distribution of the drug-loaded microspheres were evaluated. The inhibitory effects of microspheres on cancer cells were observed. We used VX2 liver cancer rabbit models to discuss the effectiveness of curcumin-loaded microspheres for hepatic artery embolization. Scanning electron microscope and particle size analysis showed that the microspheres had good sphericity. Safety testing determined that the safety index of microspheres was higher. The pharmacodynamic study showed that curcumin embolic microspheres could effectively play the role of arterial embolization after embolization administration and improve the therapeutic effect of liver cancer. Curcumin embolic microspheres had been successfully prepared in this study, which were expected to be used for embolization to improve the therapeutic efficiency- 收稿日期:2021-06-20 基金项目:河北省重点研发计划(19272701D);河北省自然科学基金资助项目(H2020201036);河北省研究生创新资助项目(CXZZSS2020002);河北省创新能力提升计划(20567605H) 第一作者:宋鹏锦(1998—),女,河北邢台人,河北大学在读硕士研究生.E-mail: 1943006472@qq.com 通信作者:胡连栋(1978—),男,河北石家庄人,河北大学教授,博士,主要从事药物新制剂研究.E-mail:hbupharm@126.com第2期宋鹏锦等:新型肝动脉栓塞微球制剂的制备of TACE in liver cancer.

Key words: hepatocellular carcinoma, curcumin, microspheres, TACE

中图分类号:

R944

宋鹏锦,韩啸,孙彩凤,孙海川,曹晓亮,胡连栋. 新型肝动脉栓塞微球制剂的制备[J]. 河北大学学报(自然科学版), 2022, 42(2): 150-157.

SONG Pengjin, HAN Xiao, SUN Caifeng, SUN Haichuan, CAO Xiaoliang, HU Liandong. Preparation of novel microsphere for hepatic arterial embolism[J]. Journal of Hebei University(Natural Science Edition), 2022, 42(2): 150-157.

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