飞秒脉冲激光产生及捕获微气泡的实验研究

doi:10.3969/j.issn.1000-1565.2019.04.005

河北大学学报(自然科学版) ›› 2019, Vol. 39 ›› Issue (4): 359-365.DOI: 10.3969/j.issn.1000-1565.2019.04.005

飞秒脉冲激光产生及捕获微气泡的实验研究

薛林雁,杨昆,曹彪,闫惟娜,刘雨航,刘爽

收稿日期:2019-03-25 出版日期:2019-07-25 发布日期:2019-07-25
通讯作者: 刘爽(1981—),女,河北保定人,河北大学副教授,博士,主要从事仪器科学与技术、光电材料的研究.E-mail:liushuanghbu@163.com
作者简介:薛林雁(1981—),女,河北广平人,河北大学副教授,博士,主要从事生物医学工程、层析成像技术及相关测试仪器的研发方向研究. E-mail:lineysnow@163.com
基金资助:
国家自然科学基金资助项目(11104058);国家重点基础研究发展规划(973计划)项目(2011CB707500);河北省自然科学基金资助项目(A2011201155);国家科技部重大科学仪器专项项目(2011YQ03011405);河北省教育厅重点项目(ZD2015044);国家科技部重点研发计划项目(2016YFC0104203)

Experimental research of microbubble generation and trapping induced by femto-second laser pulses

XUE Linyan, YANG Kun, CAO Biao, YAN Weina, LIU Yuhang, LIU Shuang

College of Quality and Technical Supervision, Hebei University, Baoding 071002, China

Received:2019-03-25 Online:2019-07-25 Published:2019-07-25

摘要/Abstract

摘要： 采用高速光学摄像及高频超声成像技术对飞秒脉冲激光在介质水中发生光学诱导击穿的过程进行实验研究.结果表明,光学诱导击穿产生后,在高能激光自聚焦的焦点处产生一系列微气泡,最后只有一个微气泡可以被激光束稳定地捕获,并且这个微气泡可以在超声作用下进行非接触式三维操控.进一步分析了沿激光束产生和捕获的微气泡的时空特性以及激光束捕获微气泡的力学特性.实验结果为应用微气泡进行分子水平的靶向性治疗提供了全新的技术手段.

关键词: 飞秒脉冲激光, 光学诱导击穿, 微气泡, 高速光学摄像, 高频超声成像

Abstract: Experimental research on dynamic process of bubble generation and trapping induced by self-focused femto-second laser pulses using fast-frame video microscopy and high frequency ultrasound imaging.Experimental results indicate that after the appearance of a series of microbubbles around the laser focus, a single microbubble generated via laser induced optical breakdown(LIOB)could be trapped stably by the self-focused SF femtosecond laser in water.The trapped bubble could be operated in the non-contact and three-dimensional way afterwards.Furthermore, the spatiotemporal and mechanical characteristics of bubble generation and trapping by self-focused femtosecond laser pulses at multiple locations along the laser beam were discussed.The experimental results can supply with new technological supports for the application of microbubble in targeted therapy at molecular level.

Key words: femto-second laser pulses, laser-induced optical breakdown(LIOB), microbubble, fast-frame video microscopy, high frequency ultrasound imaging

中图分类号:

O437.5

薛林雁,杨昆,曹彪,闫惟娜,刘雨航,刘爽. 飞秒脉冲激光产生及捕获微气泡的实验研究[J]. 河北大学学报(自然科学版), 2019, 39(4): 359-365.

XUE Linyan, YANG Kun, CAO Biao, YAN Weina, LIU Yuhang, LIU Shuang. Experimental research of microbubble generation and trapping induced by femto-second laser pulses[J]. Journal of Hebei University (Natural Science Edition), 2019, 39(4): 359-365.

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飞秒脉冲激光产生及捕获微气泡的实验研究

Experimental research of microbubble generation and trapping induced by femto-second laser pulses

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