Researches on tanshinone of salvia miltiorrhiza’s fat-soluble active ingredient

doi:10.3969/j.issn.1000-1565.2015.02.019

Abstract

Abstract: In order to obtain tanshinone of high purity and high quality,and then researched it more systematically,on the basic of reviewing?the related literature?in recent 10?years,the extraction and purification,synthesis and preparation,content determination and pharmacological effects had been researched and summarized. The Result shows that tanshinone had a higher purity and better quality with the application of modern technology,in addition,the extraction method was easy to operate and the conditions was easy to control.Among them,non ionic surfactant assisted extraction,supercritical carbon-dioxide extraction,ultrasonic extraction and ultrahigh pressure assisted extraction were economic,effective,green extraction method and had a widely application prospect.High-speed counter-current chromatography was better purification method.Currently tanshinone’s biosynthesis technology also has made remarkable achievements.Many studies of the strong pharmaceutical activities have focused on anti-tumor,antioxidant,anti-inflammatory and treatment of cardiovascular and cerebrovascular diseases and achieved good clinical results.These studies provided reference for comprehensive development and utilization of Salvia Miltiorrhiza in the future.

Key words: Tanshinone, Fat-soluble components, orthogonal design, Pharmacological activity, antibacterial

CLC Number:

R282

LI Jianheng, QIAO Yajun, HOU Lifeng, HE Xueli. Researches on tanshinone of salvia miltiorrhiza’s fat-soluble active ingredient[J]. Journal of Hebei University (Natural Science Edition), 2015, 35(2): 217-224.

References

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