Synthesis and antibacterial evaluation of L-arginine curcumin derivative

doi:10.3969/j.issn.1000-1565.2021.02.007

Abstract

Abstract: L-arginine based curcumin derivative with a succinic acid linker(Cur-Sa-Arg)was synthesized via esterification and amidation reaction using 4-dimethylaminopyridine(DMAP)and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide(EDC)as catalyzer. The product was characterized by UV-Vis, FT-IR, ¹H NMR and DSC, and the results indicated that Cur-Sa-Arg was successfully synthesized. The curcumin solubility in Cur-Sa-Arg was more than about 3 000 times higher than curcumin and reached up to 30.1 μg/mL. Moreover, the result of bacteriostatic experiment showed that the IC₅₀ values against Gram-negative bacteria including Pseudomonas aeruginosa, Escherichia coli and Salmonella ratus decreased by 3—6 times, and the IC₅₀ value against Gram-positive bacteria of Staphylococcus aureus dropped by 2 times. Compared with pure curcumin, Cur-Sa-Arg has a higher solubility and better antibacterial properties.

Key words: curcumin, L-arginine, chemical grafting, solubility, antibacterial activity in vitro

CLC Number:

LI Haiying, QIU Mingheng, CHEN Jian, WANG Guijing, YANG Wenzhi. Synthesis and antibacterial evaluation of L-arginine curcumin derivative[J]. Journal of Hebei University(Natural Science Edition), 2021, 41(2): 155-160.

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