Effects of electrostatic interactions on the movement of kinesin

doi:10.3969/j.issn.1000-1565.2017.03.003

Abstract

Abstract: Based on the crystal structure of a kinesin motor(1BG2)and tubulin(1TUB),the electric potential distribution on the surface of the motor head and the tubulin is obtained by electrostatic calculation,and the electrostatic interactions between the microtubule and the positive potential regions of kinesin are analyzed by comparing the crystal structures of them.Furthermore,through simulation by solving Poisson's equation,the electrostatic interactions of kinesin along the microtubule have been calculated,the results show that microtubule provides a periodic potential field for motor movement,and the period is consistent with that of the kinesin steps.Then combined with the calculated results, we present the electrostatic mechanism of kinesin movement.

Key words: kinesin, microtubule, the electrostatic interaction, Poisson's equation.

CLC Number:

Q615

HUANG Yanbin,GUO Haijun,LI Jie,LIU Xiuhong,JI Qing. Effects of electrostatic interactions on the movement of kinesin[J]. Journal of Hebei University (Natural Science Edition), 2017, 37(3): 237-242.

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