Synthesis,characterization and cytotoxicity of palladium(Ⅱ) complexes with β-diketonate ligands functionalized with trifluoromethyl group and 2,2’-bipyridine

doi:10.3969/j.issn.1000-1565.2017.02.005

Abstract

Abstract: A novel series of palladium(Ⅱ)complexes with β-diketonate ligands functionalized with trifluoromethyl group and 2,2’-bipyridine(bipy)have been synthesized through a directed self-assembly approach that involves spontaneous deprotonation of the β-diketone ligands in H₂O/acetone solution.These complexes have been characterized by elemental analysis,IR,¹H NMR,and HRMS.Crystal structure of 3g has been determined by X-ray diffraction analysis.The cytotoxicity was tested by MTT assay.The preliminary results showed that most of the obtained complexes were more toxic against MCF-7 and Hela than A549 cells.The cytotoxicity of complexes 3a is almost equal to that of cisplatin against MCF-7.

Key words: palladium(Ⅱ)complexes, β-diketone, trifluoromethyl, bipyridine, cytotoxicity

CLC Number:

O621

YANG Yaxing,DUAN Xiaobo,DUAN Fei,LI Shenghui,WANG Shuxiang,ZHANG Jinchao. Synthesis,characterization and cytotoxicity of palladium(Ⅱ) complexes with β-diketonate ligands functionalized with trifluoromethyl group and 2,2’-bipyridine[J]. Journal of Hebei University (Natural Science Edition), 2017, 37(2): 134-140.

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