Effects of TNF-α on sodium channel in cortical neurons of rats

doi:10.3969/j.issn.1000-1565.2018.03.008

Abstract

Abstract: Primary cultured fetal rat cortical neurons and whole cell patch clamp technique were used for investigating the effect of TNF-α on Na⁺ currents of cultured cortical neurons. The neurons were treated for 6 and 24 hours respectively by TNF-α(10 and 50 ng/mL). The results showed the inhibition of 50 ng/mL TNF-α on voltage-gated Na⁺ currents in cortical neurons of rats, but has no effect on the activation properties and the inactivation properties of sodium channel.

Key words: tumor necrosis factor -α, cortical neurons, voltage-dependent Na⁺ channel, Patch-clamp recording

CLC Number:

ZHANG Weiwei, ZHANG Han, CAO Fang, MU Shumei, KANG Xianjiang. Effects of TNF-α on sodium channel in cortical neurons of rats[J]. Journal of Hebei University (Natural Science Edition), 2018, 38(3): 278-283.

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