anticancer effect of degradable nano-yttrium oxide hollow sphere drug delivery system

doi:10.3969/j.issn.1000-1565.2019.04.006

Abstract

Abstract: Nano-yttrium oxide hollow sphere has broad application in the field of biological medicine.The uniform and well-dispersed Y₂O₃ hollow spheres(HYNPs)have been fabricated using phenolic resin spheres as template.The HYNP snot only exhibited a high DOX loading and release efficiency, but also showed the pH-sensitive degradableand drug release profiles. And the DOX release from the HYNPs-DOX in the cells increased with time. Moreover, the low cytotoxicity of HYNPs was found on MCF-7and MDA-MB-231 cells. When loaded with DOX, HYNPs-DOX exhibited a good anticancer efficiency in vitro, which showed a great potential in cancer treatment.

Key words: Y₂O₃ nanoparticle, hollow sphere, drug loading, drug release, anticancer

CLC Number:

HAN Yu, ZHANG Fangbo, YU Linkang, JIA Guang, GE Kun. anticancer effect of degradable nano-yttrium oxide hollow sphere drug delivery system[J]. Journal of Hebei University (Natural Science Edition), 2019, 39(4): 366-371.

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