Abstract: The phase-locking relationship between spike firing and local field potential(LFP)is an important neural coding information. However, the analysis of phase-locking distribution characteristics during continuous motion is still lacking.In this study, we used the phase-locking characteristics of spike and LFP delta rhythm in macaques with single-hand reach-to-grasping paradigm to analyze the phase-locking phase distribution in M1, S1 and PPC brain regions at different movement stages, at 100 ms before and after different events, and at continuous time bins.It was found that the phase-locking distribution of Spike and LFP had different phase distribution characteristics and peak position during different stages of continuous movement.In this paper, we analyzed the phase-locking phase distribution in the time bin of 100 ms before and after the occurrence of the key events TargetOn, CenterRelease and TargetHit. The results showed that the phase-locking distribution in the time bin of 100 ms before and after the occurrence of the event was significantly different, and the peak location of phase-locking increased with time.The continuous time bin was used to analyze the phase-locking phase distribution in motion, and the results showed that the phase-locking phase distribution changed with time, and this change became more dramatic before and after the CenterRelease event. Analysis of the mean difference of adjacent time bins showed that the phase-locking phase distribution changed most dramatically in the reaching stage.The regularity of the phase distribution of phase locking at different periods of time in continuous motion can provide a new way to interpret the neural information encoding in the process of motion.

Key words: spikes, local field potential, delta rhythm, phase-locking