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    25 September 2021, Volume 41 Issue 5
    Stability criteria for set differential equations with non-instantaneous impulse
    WANG Peiguang, GUO Mengyu, BAO Junyan
    2021, 41(5):  449-456.  DOI: 10.3969/j.issn.1000-1565.2021.05.001
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    Based on the theory of set differential equations and Lyapunov function method, by constructing the new comparison principles,this paper discusses the stability of solutions of the non-instantaneous impulsive set differential equations defined by Hukuhara derivative,and obtains the criteria of stability, uniform stability and uniform asymptotic stability of solutions.
    Recent advances in robust credibilistic optimization
    LIU Yankui, LIU Ying
    2021, 41(5):  457-462.  DOI: 10.3969/j.issn.1000-1565.2021.05.002
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    Robust credibilistic optimization method is an effective modeling tool to deal with the uncertainty in fuzzy credibility distribution. This paper reviews some new developments of robust credibilistic optimization in recent years. As for the theory of robust credibilistic optimization, this paper reviews the definition of parameter selection variables under different fluctuation modes and their relationship with the construction of ambiguous distribution sets, from the distinction of vertical and horizontal fluctuation directions to the setting of single parameter and double parameter selection. On the practical research of robust credibilistic optimization, we introduce some application problems, such as inventory,- DOI:10.3969/j.issn.1000-1565.2021.05.002鲁棒可信性优化的新进展刘彦奎,刘颖(河北大学 数学与信息科学学院,河北 保定 071002)刘彦奎 教授,博士生导师,省管优秀专家,研究领域包括可信性测度论、鲁棒优化、最优控制等,在所从事的研究领域中取得了多项代表性研究成果,目前已主持国家自然科学基金面上项目4项;2007年《不确定规划及其应用》项目获得教育部自然科学奖二等奖(排名第二)、2012年《机会测度理论与模糊优化方法》项目获得河北省自然科学奖二等奖(排名第一)、2018年《不确定信息简约理论与参数可信性优化方法》项目获得河北省自然科学奖二等奖(排名第一);出版中、英文学术著作6部,在多家国际知名学术期刊发表SCI/SSCI检索期刊论文70余篇;2014年至2020年连续入选Elsevier中国高被引学者榜单.摘 要:鲁棒可信性优化方法是处理模糊可信性分布中包含不确定性的一类有效建模工具.本文综述了近年来鲁棒可信性优化的一些新发展.关于鲁棒可信性优化理论,从垂直和水平波动方向的区分到单参数和双参数选择的设置,回顾了不同波动模式下参数选择变量的定义方法及其与非精确分布集构建的联系.关于鲁棒可信性优化的实践研究,介绍了一些应用问题,如库存、投资、供应链管理以及可持续发展问题,力争提供该方法最新进展的说明并探求未来研究的发展方向. 关键词:鲁棒可信性;选择变量;非精确分布集;应用研究中图分类号:TP183 文献标志码:A 文章编号:1000-1565(2021)05-0457-06Recent advances in robust credibilistic optimizationLIU Yankui, LIU Ying(College of Mathematics and Information Science, Hebei University, Baoding 071002, China )Abstract: Robust credibilistic optimization method is an effective modeling tool to deal with the uncertainty in fuzzy credibility distribution. This paper reviews some new developments of robust credibilistic optimization in recent years. As for the theory of robust credibilistic optimization, this paper reviews the definition of parameter selection variables under different fluctuation modes and their relationship with the construction of ambiguous distribution sets, from the distinction of vertical and horizontal fluctuation directions to the setting of single parameter and double parameter selection. On the practical research of robust credibilistic optimization, we introduce some application problems, such as inventory,- 收稿日期:2021-03-01 基金项目:国家自然科学基金资助项目(61773150) 第一作者:刘彦奎(1963—),男,河北三河人,河北大学教授,博士生导师,主要从事广义测度论、鲁棒优化、最优控制等领域研究. E-mail:yliu@hbu.edu.cn 通信作者:刘颖(1980—),女,河北保定人,河北大学副教授,博士,主要从事不确定优化、供应链管理、项目管理等领域研究. E-mail:yingliu@hbu.edu.cn第5期刘彦奎等:鲁棒可信性优化的新进展investment, supply chain management and sustainable development problem, and strive to provide a description of the latest progress of the method and explore the future research direction.
    Central limit theorems for branching Markov processes and superprocesses
    REN Yanxia, SONG Renming
    2021, 41(5):  463-480.  DOI: 10.3969/j.issn.1000-1565.2021.05.003
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    Some results on limit theorems for branching Markov processes and superprocesses that we have- DOI:10.3969/j.issn.1000-1565.2021.05.003分枝马氏过程与超过程的中心极限定理任艳霞1,宋仁明2,3(1.北京大学 数学科学学院,北京 100871;2.伊利诺伊大学 数学系,厄巴纳 G1801;3. 四川大学 数学系,四川 成都 610065)任艳霞 理学博士,1995年毕业于南开大学,现任北京大学数学科学学院教授、北京大学统计科学中心教授.博士生导师,本科、硕士均毕业于河北大学;2000年获得全国优秀博士学位论文奖,主要从事测度值马氏过程及分枝粒子系统的研究,在Ann Probab、Stoch Proc Appl等著名学术期刊发表SCI收录论文60余篇;承担国家自然科学基金、科技部重点研发计划、教育部高等学校博士点基金等多项科研项目.宋仁明 理学博士,1993年毕业于美国佛罗里达大学,现任美国伊利诺伊大学数学系教授,博士生导师,本科、硕士均毕业于河北大学,2019年开始任四川大学数学学院长江讲座教授,主要从事马氏过程、概率位势理论、随机分析与分枝过程的研究,在Probab Theory Related Fields、Ann Probab等著名学术期刊发表SCI收录论文140余篇,承担国家自然科学基金重点项目、面上项目、Simons Foundation Grant等多项科研项目.摘 要:给出近几年来在分枝马氏过程与超过程的极限理论方面得到的部分结果.主要包括分枝机制满足二阶矩条件的分枝Hunt过程的中心极限定理;分枝机制满足二阶矩条件的一般超过程的中心极限定理;分枝机制是空间齐次的稳定分枝机制的超OU过程的中心极限定理.文章同时涉及到大数律结果.关键词:分枝Hunt过程;超过程;大数律;中心极限定理中图分类号:O211.62 文献标志码:A 文章编号:1000-1565(2021)05-0463-18Central limit theorems for branching Markovprocesses and superprocessesREN Yanxia1, SONG Renming2,3(1.School of Mathematical Science,Peking University,Beijing 100871,China;2.Department of Mathematics,University of Illinois,Urbana G1801,United States;3.College of Mathematics,Sichuan University,Chengdu 610065,China)Abstract: Some results on limit theorems for branching Markov processes and superprocesses that we have- 收稿日期:2020-10-15 基金项目:国家自然科研基金资助项目(11931004; 12071011); Simons Foundation Grant(#429343 Renming Song)基金资助项目 第一作者:任艳霞(1965—),女,河北石家庄人,北京大学教授,博士生导师,主要从事测度值马氏过程与分枝粒子系统方向研究.E-mail: yxren@math.pku.edu.cn 通信作者:宋仁明(1963—),男,河北邯郸人,美国伊利诺伊大学教授,博士生导师,四川大学教授,主要从事马氏过程、概率位势理论、随机分析与分枝过程的研究.E-mail: rsong@illinois.edu第5期任艳霞等:分枝马氏过程与超过程的中心极限定理obtained in recent years are described. These include central limit theorems for branching Hunt processes with general branching mechanisms having finite second moment, central limit theorems for superprocesses with general branching mechanisms having finite second moment, and central limit theorems for super Ornstein-Uhlenbeck processes with spatially homogeneous branching mechanisms.The law of large numbers are also involved.
    Stampacchia lemma, generalizations and application
    GAO Hongya, GAO Siyu
    2021, 41(5):  481-487.  DOI: 10.3969/j.issn.1000-1565.2021.05.004
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    The classical Stampacchia lemma has been widely used in the regularity theory of elliptic partial differential equations and systems as well as variational problems. This paper summarizes the Stampacchia lemma and their generalizations, and give an application to the regularity theory of degenerate elliptic partial differential equations.
    Lateral photovoltaic effect in Bi2Te3/Si heterojunction
    WANG Shufang, QIAO Shuang, MA Jikui
    2021, 41(5):  488-494.  DOI: 10.3969/j.issn.1000-1565.2021.05.005
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    Bismuth telluride(Bi2Te3)is a typical topological insulator, which has wide application in thermoelectric, optoelectronic and spintronic devices. In this paper, a series of Bi2Te3 films were synthesized on the n-type single crystal Si substrate with different thicknesses by pulse laser deposition technology and the- DOI:10.3969/j.issn.1000-1565.2021.05.005Bi2Te3/Si异质结中的侧向光伏效应王淑芳,乔双,马继奎(河北大学 物理科学与技术学院,河北省光电信息材料重点实验室,新能源光电器件国家地方联合工程实验室,河北 保定 071002)王淑芳 理学博士(2004年毕业于中国科学院物理研究所),河北大学物理科学与技术学院教授,博士生导师,国务院政府特殊津贴专家,宝钢优秀教师奖和河北省青年科技奖获得者.主要从事低维光电/热电材料制备与物性调控研究,主持或参与973/863项目、973前期项目、国家自然科学基金项目、河北省自然科学基金重点项目、河北省自然科学杰出青年基金项目等多项科研项目,以第一或通信作者在Nat Commun、Adv Science、Adv Funct Mater、PRB等著名学术期刊上发表SCI收录论文120余篇,获授权国家发明专利12项、转让3项.现兼任中国光学学会理事、中国光学学会光电技术专业委员会常委、中国材料学会热电材料与应用分会理事、河北省光学学会副理事长等职.摘 要:碲化铋(Bi2Te3)是一种典型的拓扑绝缘体材料,在热电、光电和自旋电子学领域具有广阔应用前景.本文采用脉冲激光沉积技术在Si衬底上制备了不同厚度的Bi2Te3薄膜,详细研究了Bi2Te3/Si异质结中的侧向光伏响应特性.结果表明,该异质结的侧向光伏响应强烈依赖于Bi2Te3层厚度,随厚度增加呈现先快速增加至一极值,然后逐渐减小的变化趋势.用不同波长和功率的激光照射测量时发现,该异质结具有405~808 nm的较宽响应波段,且位置灵敏度随激光功率增加而增大并最终趋于饱和,其中671 nm的侧向光伏响应性能最好,最高位置灵敏度达到3.4×10-2 V/mm.以上结果为研发基于Bi2Te3的高灵敏、宽波段光位敏探测器提供了重要参考.关键词:Bi2Te3/Si;厚度调控;侧向光伏效应;宽波段;光位敏探测器中图分类号:TN362 文献标志码:A 文章编号:1000-1565(2021)05-0488-07Lateral photovoltaic effect in Bi2Te3/Si heterojunctionWANG Shufang, QIAO Shuang, MA Jikui(National-local Joint Engineering Laboratory of New Energy Photoelectric Devices, Hebei Key Laboratory of Optic-electronic Information and Materials, College of Physics Science and Technology, Hebei University, Baoding 071002, China)Abstract: Bismuth telluride(Bi2Te3)is a typical topological insulator, which has wide application in thermoelectric, optoelectronic and spintronic devices. In this paper, a series of Bi2Te3 films were synthesized on the n-type single crystal Si substrate with different thicknesses by pulse laser deposition technology and the- 收稿日期:2021-05-15 基金项目:国家自然科学基金面上项目(51972094 );河北省自然科学基金杰出青年项目(F2018201198) 第一作者:王淑芳(1974—),女,河北张家口人,河北大学教授,博士生导师,主要从事新型光电/热电能量转换材料设计、物性调控及器件研究. E-mail:sfwang@hbu.edu.cn第5期王淑芳等:Bi2Te3/Si异质结中的侧向光伏效应lateral photovoltaic effect in them were well studied. The results show that the lateral photovoltage of the heterojunction is strongly dependent on the thickness of Bi2Te3 layer. With the increase of the thickness, the lateral photovoltage first increases rapidly to an extreme value, and then decreases gradually. When measured at different wavelengths and laser power, it is found that the heterojunction has a wide response band of 405—808 nm, and the position sensitivity increases with an increase of laser power and finally tends to reach saturation. Among them, the heterojunction shows the best lateral photovoltaic response at 671 nm, and the maximum position sensitivity reaches 3.4×10-2 V/mm. This result provides an important experimental basis for the development of Bi2Te3 based high sensitivity and broad band light position sensitive detector.
    Influence of voltage parameters on the morphology of plasma plume in atmospheric pressure plasma jet
    LI Xuechen, CHEN Junyu, JIA Pengying, WU Jiacun, RAN Junxia
    2021, 41(5):  495-502.  DOI: 10.3969/j.issn.1000-1565.2021.05.006
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    Atmospheric pressure plasma jet has the ability to generate a kind of remote plasma in open air, also referred to as plasma plume, which is abundant with active species. The plasma jet has extensive application prospects in various fields, such as material synthesis, surface modification, biomedicine, and environmental protection, etc. The morphology of plasma plume is related with the distribution of active species, which is important for the investigation of plasma jet.Up to now, only a few plume morphologies have been observed in experiment. Aim to this status, an argon plasma jet is utilized to investigate the plume morphology in this paper. With varying voltage parameters including amplitude, frequency and biased value, several morphologies are observed for the first time, such as a diffuse cone, a corona and a central filament(DAF), a bead string, and a hollow structure. These results obviously enrich the plume morphology. Through comparing their waveforms for the different morphologies, it is found that plasma plume with the other three morphologies(except the DAF)presents one emission pulse per voltage cycle. Moreover, the emission pulse appears at the negative half cycle,corresponding to a negative discharge for the diffuse cone and the bead string. However, the hollow plume presents the emission pulse at the positive half cycle(a positive discharge). As a comparison, there are two emission pulses for the DAF plume, one of which is a negative discharge and the other corresponds to a positive discharge. In addition, spatial and temporal evolutions are conducted by an emICCD for the different plumes. Results reveal that the negative discharge corresponds to a negative streamer, while the positive discharge is a positive streamer. The different morphologies observed by naked eyes are temporally integrated results of the negative streamer and the positive streamer. These results are of great significance for the profound investigation of plume morphology and further study of streamer dynamics.
    Regulation of hydrogenation performance of dioctyl phthalate over nickel-based nano-catalysts derived from hydrotalcite
    BAI Guoyi, NIE Shilin, LI Wenjiong
    2021, 41(5):  503-510.  DOI: 10.3969/j.issn.1000-1565.2021.05.007
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    Hydrogenation of dioctyl phthalate is the most important method for the synthesis of cyclohexane-1, 2-dioctyl diphthalate, which is an environmentally friendly plasticizer. A nickel-based nano-catalyst Ni-AlO was prepared from a nickel-aluminum hydrotalcite precursor. The conversion of dioctyl phthalate- DOI:10.3969/j.issn.1000-1565.2021.05.007水滑石衍生镍基纳米催化剂对邻苯二甲酸二辛酯加氢反应的调控白国义,聂世琳,李文炅(河北大学 化学与环境科学学院,河北 保定 071002)白国义 河北大学教授,博士生导师.国家百千万人才工程人选、河北省杰出专业技术人才、河北省政府特殊津贴专家、河北省"三三三人才工程"第一层次人选.现任河北大学学术委员会副主任、化学与环境科学学院副院长、中国化工学会精细化工专业委员会常务委员、河北省化学会常务理事、《精细化工》等杂志编委.主持了国家自然科学基金、河北省自然科学基金杰出青年基金、河北省自然科学基金重点项目等20余项纵向和横向课题;近5年作为通信作者在ACS Catalysis等国内外学术期刊上发表论文37篇,包括中科院一区论文13篇;积极致力于科技成果转化和服务社会,作为第一完成人获得2018年度河北省科学技术进步一等奖.摘 要:邻苯二甲酸二辛酯加氢是合成环保型增塑剂环己烷-1, 2-二甲酸二辛酯最重要的方法.本文以镍铝水滑石作为前驱体,制备了一种Ni-AlO纳米催化剂.在此催化剂作用下,邻苯二甲酸二辛酯的转化率和环己烷-1, 2-二甲酸二辛酯的选择性均可达99%,而在对比催化剂Ni-Al2O3作用下,邻苯二甲酸二辛酯的转化率仅为20%.此外,Ni-AlO催化剂的稳定性也明显优于后者.透射电子显微镜、程序升温还原和X光电子能谱等表征表明水滑石前驱体的生成对活性组分镍起到了分散作用,并提高了其与载体的相互作用,使Ni-AlO催化剂具有优异的催化性能.关键词:邻苯二甲酸二辛酯;环己烷-1, 2-二甲酸二辛酯;加氢;催化剂;水滑石中图分类号:O643.38 文献标志码:A 文章编号:1000-1565(2021)05-0503-08Regulation of hydrogenation performance of dioctyl phthalate over nickel-based nano-catalysts derived from hydrotalciteBAI Guoyi, NIE Shilin, LI Wenjiong(College of Chemistry and Enviromental Science, Hebei University, Baoding 071002,China)Abstract: Hydrogenation of dioctyl phthalate is the most important method for the synthesis of cyclohexane-1, 2-dioctyl diphthalate, which is an environmentally friendly plasticizer. A nickel-based nano-catalyst Ni-AlO was prepared from a nickel-aluminum hydrotalcite precursor. The conversion of dioctyl phthalate- 收稿日期:2021-05-01 基金项目:国家自然科学基金面上项目(22078080;21676068);河北省自然科学基金重点项目(B2019201341) 第一作者:白国义(1975—),男,回族,河北沧州人,河北大学教授,博士生导师,博士,主要从事精细化工和催化领域研究.E-mail:baiguoyi@hotmail.com.第5期白国义等:水滑石衍生镍基纳米催化剂对邻苯二甲酸二辛酯加氢反应的调控and the selectiviy for dioctyl cyclohexane-1, 2-dioctyl diphthalate were both 99% catalyzed by this catalyst, however, the conversion of dioctyl phthalate was only 20% over a Ni-Al2O3 catalyst. Furthermore, Ni-AlO was more stable than Ni-Al2O3. TEM, TPR and XPS characterizations revealed that the hydrotalcite precursor benefited for not only the dispersion of Ni, but also its interaction with the support, and in turn improved the catalytic performance of Ni-AlO.
    Screening methods of natural bioactive compounds based on the affinity ultrafiltration techniques
    WANG Zhiqiang, HAN Yehong, YAN Hongyuan
    2021, 41(5):  511-527.  DOI: 10.3969/j.issn.1000-1565.2021.05.008
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    The interaction between medicinal substance and drug target is the basis of biological activity- DOI:10.3969/j.issn.1000-1565.2021.05.008基于亲和超滤技术的天然活性物质筛选方法王志强1,韩晔红2,闫宏远1,2(1.河北大学 公共卫生学院,河北省公共卫生安全重点实验室,河北 保定 071002;2.河北大学 药学院,药物化学与分子诊断教育部重点实验室,河北 保定 071002)闫宏远 工学博士,河北大学教授,博士生导师.河北省杰出青年基金获得者,河北省“三三三人才工程”人选,河北省高校百名优秀创新人才;现任中国医检整合联盟常务理事、河北省预防医学会副理事长、河北省检验检疫学会副理事长、河北省分析仪器技术学会副理事长、河北省健康学会常务理事、《中华疾病控制杂志》常务编委、《医学理论与实践》编委、河北省公共卫生安全重点实验室主任.近年来主持国家自然科学基金面上项目、河北省自然科学基金重点项目等10余项,在国际学术期刊上发表研究论文50余篇;授权国家发明专利6项;2016年获河北省自然科学奖三等奖,2019年获河北省科技进步奖二等奖.2020年入选“中国高被引学者”和斯坦福大学发布的“2020全球前2%顶尖科学家”榜单.摘 要:药效物质与药物靶标的相互作用是其生物活性的基础,利用药物靶标亲和选择性“钩钓”其特异性配体,可以实现复杂提取物中天然活性物质分析的“精准制导”.亲和超滤是一种以上述原理为基础,将亲和捕获与超滤分离相结合以实现化合物高通量筛选的技术,具有快速、简单、高效等特点,常与液质联用等分析技术联合使用,克服了天然活性物质筛选研究面临的诸多问题,近年来被广泛应用于天然活性物质的快速靶向筛选.本文从亲和超滤技术本身的原理、影响因素及与其他分析技术的联用情况等方面,详细综述了亲和超滤技术的特点和应用现状,以期为构建天然活性物质的快速筛选策略提供科学思路和依据.关键词:亲和超滤;天然活性物质;筛选方法中图分类号:R917;R93 文献标志码:A 文章编号:1000-1565(2021)05-0511-17Screening methods of natural bioactive compounds based on the affinity ultrafiltration techniquesWANG Zhiqiang1, HAN Yehong2, YAN Hongyuan1,2(1. Key Laboratory of Public Health Safety of Hebei Province, College of Public Health, Hebei University, Baoding 071002,China;2. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Pharmaceutical Sciences, Hebei University, Baoding 071002,China)Abstract: The interaction between medicinal substance and drug target is the basis of biological activity- 收稿日期:2021-06-08 基金项目:国家自然科学基金资助项目(81803401;82073605);河北省自然科学基金资助项目(H2019201186) 第一作者:王志强(1989—),男,黑龙江鹤岗人,河北大学副教授,主要从事天然活性物质筛选研究.E-mail:wangzq2017@hbu.edu.cn 通信作者:闫宏远(1975—),男,河北高阳人,河北大学教授,博士生导师,主要从事药物分离分析技术研究.E-mail:yanhy@hbu.edu.cn第5期王志强等:基于亲和超滤技术的天然活性物质筛选方法for the medicinal substance, and “precise guidance” of natural bioactive compounds from complex extracts can be achieved by the selective affinity of drug target, just like “fishing”. Affinity ultrafiltration is a technology that combines affinity capture and ultrafiltration separation for high-throughput screening of bioactive compounds based on the above principles, which is often coupled with liquid chromatography-mass spectrometry, overcoming lots of problems in discovering bioactive natural products. This paper reviewed in detail the characteristics and application status of affinity ultrafiltration technology, influencing factors, and the combination with other analytical technologies, in order to provide scientific ideas and basis for the construction of rapid screening strategies for natural active substances.
    Fluorinated surfactant modified silica gel chromatographic stationary phase: preparation and its separation performance
    QIAO Xiaoqiang, NIE Yangyang, DUAN Liguang, LIANG Mengying
    2021, 41(5):  528-534.  DOI: 10.3969/j.issn.1000-1565.2021.05.009
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    A fluorinated surfactant, 1-vinyl-3-perfluorooctylethylimidazole iodide(VIMF), was first- DOI:10.3969/j.issn.1000-1565.2021.05.009氟化表面活性剂修饰硅胶色谱固定相制备及分离性能乔晓强1,聂扬扬1,段立广2,梁梦颖1(1. 河北大学 药学院,河北 保定 071002;2. 河北医科大学第一医院 药学部,河北 石家庄 050000)乔晓强 理学博士,河北大学教授,博士生导师.现任河北大学药学院副院长,河北省杰出青年基金获得者,河北省青年拔尖人才,河北省高校百名优秀创新人才,入选河北省“三三三人才工程”.2011年3月于中科院大连化学物理研究所获博士学位.2011年6月进入河北大学药学院工作.2016~2018年先后在美国德州大学阿灵顿分校和密西根州立大学进行博士后研究.先后主持国家自然科学基金项目2项,河北省自然科学基金项目3项,中国博士后科学基金1项,河北省科技支撑项目1项.2017年获河北省科技进步二等奖.迄今为止,在Analytical Chemistry、ACS Applied Materials & Interfaces、TrAC-Trends in Analytical Chemistry等权威期刊发表SCI论文50余篇,授权发明专利3项,在科学出版社出版《药学文献检索》1部.摘 要:以1-乙烯基咪唑和1-碘-1H,1H,2H,2H-全氟癸烷为原料合成了含氟表面活性剂——碘化1-乙烯基-3-全氟辛基乙基咪唑(VIMF).进一步将VIMF作为可聚合单体,利用巯基-烯点击反应,制备了VIMF键合硅胶色谱固定相(Sil-VIMF).采用傅里叶变换红外光谱和热重分析对Sil-VIMF固定相材料进行表征,结果证明了其成功制备.保留机制考察结果表明,Sil-VIMF固定相具有亲水作用色谱保留机制.色谱分离性能研究结果表明,Sil-VIMF固定相可实现酰胺类、核苷和核碱基类、苯胺类物质的良好分离,其柱效可达79 200 N/m.进一步将Sil-VIMF固定相用于胃癌细胞膜脂提取物的分离分析,可实现胃癌细胞膜中磷脂酰胆碱和磷脂酰乙醇胺的有效分离分析,显示了良好的应用潜能.关键词:氟表面活性剂;色谱固定相;亲水作用色谱;膜脂分离中图分类号:O657.7 文献标志码:A 文章编号:1000-1565(2021)05-0528-07Fluorinated surfactant modified silica gel chromatographic stationary phase: preparation and its separation performanceQIAO Xiaoqiang1, NIE Yangyang1, DUAN Liguang2, LIANG Mengying1(1. College of Pharmaceutical Science, Hebei University, Baoding 071002, China; 2. Department of Pharmacy, The First Hospital of Hebei Medical University, Shijiazhuang 050000, China)Abstract: A fluorinated surfactant, 1-vinyl-3-perfluorooctylethylimidazole iodide(VIMF), was first- 收稿日期:2021-03-20 基金项目:河北省杰出青年科学基金资助项目(B2019201327);河北省百名优秀创新人才支持计划(SLRC2019016) 第一作者:乔晓强(1982—),男,河北宁晋人,河北大学教授,主要从事色谱分离分析新材料研究.E-mail: hbuqiao@163.com 通信作者:段立广(1984—),男,河北邢台人,河北医科大学第一医院主管药师,主要从事药物新剂型相关研究. E-mail: dlg123456@163.com梁梦颖(1993—),女,河北保定人,河北大学硕士研究生,主要从事色谱分析研究.E-mail: 1296972375@qq.com第5期乔晓强等:氟化表面活性剂修饰硅胶色谱固定相制备及分离性能synthesized using 1-vinylimidazole and 1-iodo-1H,1H,2H,2H-perfluorodecane as the raw materials. With VIMF as a polymerizable monomer, VIMF bonded silica gel chromatographic stationary phase(Sil-VIMF)material was prepared by thiol-ene click reaction. Fourier transform infrared spectroscopy and thermogravimetric analysis were used for characterization the Sil-VIMF material. The results proved the successful preparation of Sil-VIMF stationary phase material. The retention mechanism investigation results show that the Sil-VIMF stationary phase has a hydrophilic interaction chromatography retention mechanism. Chromatographic separation performance results show that Sil-VIMF stationary phase can achieve good separation for amides, nucleosides/nucleobases, and anilines. The column efficiency can reach 79 200 N/m. The Sil-VIMF stationary phase was further used for the separation and analysis of gastric cancer cell membrane lipid extracts. The effective separation and analysis of phosphatidylcholine and phosphatidylethanolamine was achieved, indicating good application potential.
    Research progress in design of the organic fluorescence probes and its application for the detection of tumor biomarker
    DUAN Xinrui, MENG Tianjiao
    2021, 41(5):  535-544.  DOI: 10.3969/j.issn.1000-1565.2021.05.010
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    Fluorescence imaging with high spatial-temporal resolution and high sensitivity provides a powerful tool for visualizing dynamic biological processes. Recently, fluorescence imaging is widely used in molecular biology, cellular immunology, microbiology and oncology. Organic fluorescent probes have high safety, good biocompatibility and strong optical stability. At present, a series of organic fluorescent probes have been developed, including polydopamine nanoparticles, organic small molecule dyes, near-infrared- DOI:10.3969/j.issn.1000-1565.2021.05.010有机小分子荧光探针的设计及其在酶类肿瘤标志物检测中的研究进展段新瑞,孟天姣(陕西师范大学 化学化工学院,陕西 西安 710119)段新瑞 理学博士,陕西师范大学化学化工学院教授,博士生导师.2003年毕业于河北大学化学与环境科学学院并获理学学士学位,2006 年毕业于河北大学获理学硕士学位,2010年毕业于中国科学院化学研究所并获理学博士学位,随后在美国南卡罗莱纳大学化学与生物化学学院进行博士后研究.主要从事癌干细胞成像、分离与相关核酸标志物检测方法学研究.在J Am Chem Soc、Chem Sci、Nat Protoc、Adv Mater、Anal Chem以及Acc Chem Res等国际知名学术杂志上发表论文50余篇.摘 要:高时空分辨率和高灵敏度的荧光成像技术是一种新兴的活体可视化检测工具,广泛应用于分子生物学、细胞免疫学、微生物学以及肿瘤学等领域.由于有机荧光探针具有安全性高、生物相容性好、光学稳定性强等优点,目前已开发了一系列生物相容性好、具有易于修饰、调节光谱且易于被生物体代谢的有机小分子荧光探针,包括可见光区有机小分子染料以及近红外有机染料等.本文综述了近些年新型有机小分子荧光探针在2种肿瘤标志物检测中的研究进展.关键词:荧光成像;有机荧光探针;肿瘤标志物 中图分类号:O157.1 文献标志码:A 文章编号:1000-1565(2021)05-0535-10Research progress in design of the organic fluorescence probes and its application for the detection of tumor biomarkerDUAN Xinrui, MENG Tianjiao(School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xian 710119,China)Abstract: Fluorescence imaging with high spatial-temporal resolution and high sensitivity provides a powerful tool for visualizing dynamic biological processes. Recently, fluorescence imaging is widely used in molecular biology, cellular immunology, microbiology and oncology. Organic fluorescent probes have high safety, good biocompatibility and strong optical stability. At present, a series of organic fluorescent probes have been developed, including polydopamine nanoparticles, organic small molecule dyes, near-infrared- 收稿日期:2021-05-10 基金项目:中央高校基本科研业务费项目重点项目(GK202002013) 第一作者:段新瑞(1981—),男,河北邯郸人,陕西师范大学教授、博士生导师,主要从事癌干细胞成像、分离与相关核酸标志物检测方法学研究.E-mail:duanxr@snnu.edu.cn第5期段新瑞等:有机小分子荧光探针的设计及其在酶类肿瘤标志物检测中的研究进展organic dyes, conjugated polymers and their nanoparticles. This paper reviews the recent research progress of organic small fluorescence probes in the detection of two tumor biomarkers.
    Review of studies on analysis of food safety and drug metabolism
    SUN Hanwen
    2021, 41(5):  545-550.  DOI: 10.3969/j.issn.1000-1565.2021.05.011
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    The development of modern analytical chemistry is described briefly. The progress of studies on separation science, food safety and drug metabolism analysis by the graduates under the author direction for nearly two decades is reviewed. The further development of foodomics and trug metabolomics analysis is expected.
    Tethyan changes shaped global animal distribution
    LI Shuqiang, ZHAO Zhe, HOU Zhonge
    2021, 41(5):  551-564.  DOI: 10.3969/j.issn.1000-1565.2021.05.012
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    The Tethys Sea was an ancient ocean that existed between the continents of Gondwana and - DOI:10.3969/j.issn.1000-1565.2021.05.012特提斯海变迁对全球动物分布的影响李枢强,赵喆,侯仲娥(中国科学院 动物研究所, 动物进化与系统学重点实验室, 北京 100101)李枢强 博士,研究员,博士生导师,1985年毕业于河北大学生物系并获学士学位;1988年后在中国科学院动物研究所参加工作至今,是中国动物学会蛛形学专业委员会主任委员, Zoological Systematics主编;创办亚洲蜘蛛学会并任秘书长(2012年至今),创办国际虚拟蜘蛛分类研究所(2016 年至今),是世界蜘蛛名录7 位专家组成员之一;2011~2014 年承担国家杰出青年科学基金项目;1998年因研究化学农药对节肢动物的选择作用在德国获克诺尔科技奖,2009年因命名2 000余新物种使中国生物种类增加1%获周尧昆虫分类学奖励基金一等奖;近年主要基于生物地理学方法研究特提斯海变迁和青藏高原隆升对物种多样性的影响,发现特提斯海消退塑造了现生生物的分布格局;揭示了无脊椎动物全球多样性的起源和分化格局;在PNAS、Systematic Biology、Global Change Biology、Biological Reviews等刊物上共发表科研论文400余篇.摘 要:特提斯海是曾存在于冈瓦纳古陆和劳亚古陆之间的古海洋.特提斯海在其近2亿年的演化历程中,经历了扩张、分裂、收缩直至消亡.本文回顾了特提斯海区域不同动物类群的多样性研究,系统总结了特提斯海演化和变迁对全球动物多样性格局的影响.特提斯海演化通过改变栖息地之间的物理联系,决定了动物的扩散和隔离,进而直接影响了现今全球动物多样性的空间分布和组成;特提斯海的海陆变迁通过改变区域地理和生态环境,如阿尔卑斯-喜马拉雅造山带的形成、淡水生境的出现、中亚地区的干旱化、地中海盐度危机的发生,以及新的洞穴和湖泊生境的形成等,间接影响了特提斯海区域内动物的起源、扩散、分化、存留和灭绝.本文强调了特提斯海的演化和变迁是全球动物多样性演化的重要驱动因素,并揭示了特提斯海区域现今动物多样性格局的形成与地质构造运动之间的潜在联系.关键词:古地中海;系统发育;生物地理;辐射演化;适应性进化;灭绝中图分类号:Q935.2 文献标志码:A 文章编号:1000-1565(2021)05-0551-14Tethyan changes shaped global animal distributionLI Shuqiang, ZHAO Zhe, HOU Zhonge(Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China)Abstract: The Tethys Sea was an ancient ocean that existed between the continents of Gondwana and - 收稿日期:2021-05-22 基金项目:国家自然科学基金面上项目(31772418);中国科学院青年创新促进会项目(2019087) 第一作者:李枢强(1965—),男,河北保定人,中国科学院动物研究所研究员,博士生导师,主要从事特提斯海变迁与动物多样性演化等方向的研究. E-mail:lisq@ioz.ac.cn 通信作者:赵喆(1986—),男,辽宁沈阳人,中国科学院动物研究所助理研究员,博士,主要从事蜘蛛分类、欧亚地区物种多样性起源与演化等方向的研究. E-mail:zhaozhe@ioz.ac.cn第5期李枢强等:特提斯海变迁对全球动物分布的影响Laurasia. The Tethys Sea has experienced dramatic changes from expansion, split, narrowing to extinction in its 200 million-year evolutionary history. This paper reviews the diversity studies of different animals in the Tethyan region, and systematically summarizes the impacts of the evolution and changes of the Tethys Sea on the global diversity patterns of animals. The Tethyan evolution has directly affected the current distribution and composition of global animal diversity by changing the physical connection between habitats, which determined the dispersal and isolation of animals. The Tethyan sea-land changes have indirectly affected the origin, dispersal, diversification, maintaining and extinction of animals in the Tethyan region by changing regional topographies and ecological environments, such as the formation of the Alpine-Himalayan orogenic belt, the emergence of freshwater habitats, the aridification of Central Asia, the occurrence of Messinian salinity crisis, and the emergence of the new cave and lake habitats. This paper emphasizes that the evolution and changes of the Tethys Sea is an essential driving force for the evolution of global animals and reveals the potential links between the formation of the current diversity patterns of animals and the series of tectonic activities in the Tethyan region.
    Research progress of loop-mediated isothermal amplification technology
    SHI Lei, WANG Man, SHI Guoqiang, DONG Zhenguo, LIU Yu
    2021, 41(5):  565-571.  DOI: 10.3969/j.issn.1000-1565.2021.05.013
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    Loop-mediated isothermal amplification(LAMP)is an efficient, simple, highly specific nucleic acid amplification technology without thermal cycling equipment.As LAMP still has great potential for- DOI:10.3969/j.issn.1000-1565.2021.05.013环介导等温扩增技术研究进展石磊1,王曼2,时国强3,董振国3,刘昱2(1.暨南大学 食品安全与营养研究院,广东 广州 510000;2.河北农业大学 生命科学学院,河北 保定 071003; 3. 河北三狮生物科技有限公司 研发部,河北 石家庄 050000)石磊 博士,教授,博士生导师,1985年毕业于河北大学生物系并获学士学位,现任暨南大学食品安全与营养研究院院长,河北农业大学生命科学学院特聘兼职教授;国家重大人才工程入选者,国家重点研发计划首席科学家,肉食品安全生产技术国家重点实验室主任,第一届国家食品安全标准审评委员会委员,中国食源性微生物检测技术创新战略联盟副理事长,广东省免疫学会副理事长,广州双螺旋基因技术有限公司董事长;主要从事病原微生物快速诊断方法、临床微生物耐药基因解析及耐药性基因诊断研究;在SCI收录期刊上发表论文100余篇,申请专利26项,其中发明专利25项,实用新型专利1项;先后主持“国家重点研发计划”、“国家973计划项目”、“国家海洋经济创新发展区域示范专项”等10余项国家级项目;2018年获中国人民解放军军队科技进步二等奖,2019年获第四届中国水产学会范蠡科学技术奖技术推广奖、优秀成果奖.摘 要:环介导等温扩增(loop-mediated isothermal amplification,LAMP)技术是一种高效、简便、高特异性、无需热循环设备的核酸扩增技术. 由于LAMP依然具备巨大的改造潜力,所以近些年来,一直有研究改进其技术以期达到更好的扩增检测效果. 本文对LAMP的基本原理、应用领域范围以及技术改良方向进行了综述,为今后该技术的改良与发展提供参考. 关键词:环介导等温扩增(LAMP);技术改良;发展方向中图分类号:Q7 文献标志码:A 文章编号:1000-1565(2021)05-0565-07Research progress of loop-mediated isothermal amplification technologySHI Lei1, WANG Man2, SHI Guoqiang3, DONG Zhenguo3, LIU Yu2(1. Institute of Food Safety and Nutrition,Jinan University, Guangzhou 510000, China; 2. College of Life Science, Agricultural University of Hebei, Baoding 071003, China; 3.Research and Development Department,Hebei Sanshi Biological Technology Co., LTD, Shijiazhuang 050000, China)Abstract: Loop-mediated isothermal amplification(LAMP)is an efficient, simple, highly specific nucleic acid amplification technology without thermal cycling equipment.As LAMP still has great potential for- 收稿日期:2021-06-16 基金项目:河北省创新能力提升计划项目(205A7601D);石家庄市高层次科技创新创业人才项目(05202001) 第一作者:石磊(1961—),男,河北保定人,暨南大学教授,博士生导师,主要从事病原微生物核酸分子检测等研究. E-mail:leishi88@139.com 通信作者:刘昱(1990—),男,山东临沂人,河北农业大学在读博士研究生,主要从事病原微生物核酸分子检测的研究.E-mail:1085869940@qq.com第5期石磊等:环介导等温扩增技术的研究进展modification, many studies have been conducted in recent years to improve its technology in order to achieve better amplification detection results.In this paper, the basic principle, application scope and technical improvement direction of LAMP were reviewed, to provide references for the improvement and development of LAMP technology in the future.
    Competition and induction inhibition of bacterium HT-6 on mycelia growth of Phytophthora infestans
    JIANG Jizhi, ZHANG Congying, LIANG Jiao, QIAO Liu, MENG Cuili
    2021, 41(5):  572-580.  DOI: 10.3969/j.issn.1000-1565.2021.05.014
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    In order to deeply understand the antagonistic mechanism of bacterium HT-6 against Phytophthora infestans, the agar column method was used to observe the competition in spatial position between HT-6 strain and P. infestans. Chrome Azurol Sulphonate(CAS)medium was used to survey and determine the production of siderophore. Sulfuric acid anthrone colorimetric method and salicylic acid-concentrated sulfuric acid colorimetry method were used to compare the utilization rates of glucose and nitrate nitrogen, respectively. At the same time, P. infestans and its cell wall preparation(CWP)were used as inducers to induce the cellulase and β-1,3-glucanase produced by HT-6, which were observed based on the plate transparent circle method and measured with DNS method. The inhibition of HT-6 free cell fermentation liquid induced by CWP on P. infestans mycelia growth was evaluated with dual culture method. The results showed that P. infestans mycelia inoculated on PDA column alone could grow along column and spread quickly onto Rye medium, HT-6 docked with P. infestans on the agar column could rapidly grow and spread on the surface of the Rye medium, as well, while P. infestans docked with HT-6 on the agar column grew only in agar column and was inhibited by HT-6; HT-6 could produce siderophore, while P. infestans could not. The utilization rates of glucose(75.66%)and nitrate nitrogen(69.05%)by HT-6 were significantly higher than those of P. infestans(55.97% and 56.87%), respectively. And HT-6 strain could not produce cellulase and β-1,3-glucanase as it was cultured alone, but both P. infestans strain and its CWP could induce HT-6 to produce these two enzymes. Activities of cellulase and β-1,3-glucanase induced by P. infestans strain were 6.638,2.913 U, while those by CWP were 1.326,1.289 U, respectively. There was a significant difference between two induction treatments(P<0.05); HT-6 free cell fermentation liquid containing two enzymes after CWP induction had a significant inhibitory effect on P. infestans mycelia growth, inhibition rate was 33.25%, but it was significantly lower than that of the HT-6 bacterial solution, inhibition rate reached up to 81.33%. It indicated that the bacterium HT-6 can inhibit the P. infestans through both the competition of space and nutrition,and producing the cell wall degrading enzymes induced by P.infestans, in which space and nutrition competition are dominant.
    Description of two species of Conothele Thorell, 1878 from Tibet, China(Mygalomorphae: Halonoproctidae)
    ZHANG Feng, YU Kun
    2021, 41(5):  581-586.  DOI: 10.3969/j.issn.1000-1565.2021.05.015
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    Two species of Conothele Thorell, 1878 from Tibet are described and illustrated in this article: Conothele linzhi H. Liu, Xu, Zhang, F. Liu & Li, 2019 and Conothele medoga sp. nov.; the male of C. linzhi is described for the first time.
    A double mode measurement method of asymmetric relationship between scientific documents
    XU Jianmin, WANG Xin
    2021, 41(5):  587-598.  DOI: 10.3969/j.issn.1000-1565.2021.05.016
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    Aiming at the problem of different degree of similarity and influence between scientific documents, a new measurement method is proposed by analyzing the asymmetric relationship between scientific documents.This method defines the asymmetric relationship between scientific documents as document coverage, and uses formula coverage and text coverage to measure it.The formula coverage is- DOI:10.3969/j.issn.1000-1565.2021.05.016科技文档间非对称关系的双模态度量方法徐建民,王鑫(河北大学 网络空间安全与计算机学院,河北 保定 071002)徐建民 管理学博士,现任河北大学教授,河北大学计算机科学与技术专业硕士生导师,管理科学与工程专业、图书情报与档案专业博士生导师,入选河北省省管优秀专家,教育部科技委管理学部委员. 曾出版高等学校教材10部,学术专著1部,发表科研论文100余篇,获河北省教学成果一、二、三等奖各1项,国家教学成果奖1项,获河北省科技进步二、三等奖各1项,河北省社会科学优秀成果一等奖1项. 主要研究方向为信息检索、个性化推荐、在线社交网络分析、网络舆情监测与分析.摘 要:针对科技文档间相似程度和影响力不同的问题,通过分析科技文档间非对称关系,提出一种新的度量方法.该方法将科技文档间非对称关系定义为文档覆盖度,并用公式覆盖度和文本覆盖度对其进行度量.公式覆盖度由改进的非对称因子计算,文本覆盖度通过利用文本的相对突出性调整特征向量的余弦夹角计算,公式覆盖度和文本覆盖度线性融合得到科技文档覆盖度.实验结果表明:与已有的2种科技文档关系度量方法相比,本文提出的非对称关系度量方法在聚类中的平均准确率分别提高了8%和4%.关键词:科技文档;非对称性;覆盖度;关系度量中图分类号:TP391 文献标志码:A 文章编号:1000-1565(2021)05-0587-12A double mode measurement method of asymmetric relationship between scientific documentsXU Jianmin, WANG Xin(College of Cyberspace Security and Computer, Hebei University, Baoding 071002, China)Abstract: Aiming at the problem of different degree of similarity and influence between scientific documents, a new measurement method is proposed by analyzing the asymmetric relationship between scientific documents.This method defines the asymmetric relationship between scientific documents as document coverage, and uses formula coverage and text coverage to measure it.The formula coverage is- 收稿日期:2021-03-05 基金项目:国家社会科学基金后期资助项目(17FTQ002);河北省自然科学基金资助项目(F2015201142) 第一作者:徐建民(1966—),男,河北邯郸人,河北大学教授,博士生导师,主要从事信息检索、在线社交网络方向研究.E-mail: hbuxjm@hbu.edu.cn 通信作者:王鑫(1996—),男,河北保定人,河北大学在读硕士研究生,主要从事信息检索方向研究.E-mail:838148632@qq.com第5期徐建民等:科技文档间非对称关系的双模态度量方法calculated by an improved asymmetric factor, and the text coverage is calculated by using the relative prominence of the text to adjust the cosine angle of the feature vector, The formula coverage and text coverage are linearly fused to obtain the coverage of scientific documents.The experimental results show that compared with the existing two measurement methods for relationship between scientific documents, the average accuracy of the asymmetric relationship measurement method proposed in this paper is improved by about 8 percentage points and 4 percentage points.
    A review of proof of data possession in cloud storage environment
    TIAN Junfeng, SONG Qianqian, WANG Haoning
    2021, 41(5):  599-611.  DOI: 10.3969/j.issn.1000-1565.2021.05.017
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    With the development of network storage technology, more and more users choose to store data in the cloud, thus users lose direct control of the data. How to verify the integrity of the data stored in the cloud becomes one of the most concerned issue. Proof of Data Possession(PDP)mechanism is considered to be an important means to solve this problem in academia and industry. This paper discusses- DOI:10.3969/j.issn.1000-1565.2021.05.017云存储环境下数据持有性证明研究综述田俊峰,宋倩倩,王浩宁(河北大学 网络空间安全与计算机学院,河北 保定 071002)田俊峰 河北大学教授,博士生导师,现任网络空间安全与计算机学院院长,河北省高可信信息系统重点实验室主任.1986年毕业于河北大学电子系,2004年博士毕业于中国科技大学计算机科学与技术专业.河北省网络安全学会理事长,《通信学报》《网络与信息安全学报》《信息安全研究》编委,中国计算机学会分布式计算与系统委员会委员.先后被评为河北省具有突出贡献的中青年专家,河北省具有突出贡献的中青年教师,河北省“三三三人才工程”人选,2016年度宝钢奖优秀教师.多年来一直从事分布计算、网络安全与可信计算等方向的教学和科研工作.主持国家自然科学基金、河北省杰出青年科学基金、河北省自然科学基金、军地委托开发项目等基金项目30余项.在国内外重要学术期刊和会议上发表学术论文80余篇,主编出版专著2部,课程教材3部.获河北省科技进步奖4项,军队科技进步奖1项,河北省优秀教学成果二等奖1项. 摘 要:随着网络存储技术的发展,越来越多的用户选择将数据存储到云端,从而用户失去对数据的直接控制.如何验证存储在云端的数据完整性便成为用户最关心的问题之一.学术界和工业界普遍认为数据持有性证明(provable data possession,PDP)机制是解决该问题的重要手段,本文对现有的部分经典数据持有性证明方案进行了梳理.给出了数据持有性证明系统模型和审计框架;分析了数据持有性证明系统的功能特性和安全需求;分别从实现原理、应用场景和不同实体3个不同的视角,对目前主要的数据持有性证明方案进行了总结归纳,并对未来的研究趋势进行了展望.关键词:云存储;数据完整性;数据持有性证明中图分类号:TP301 文献标志码:A 文章编号:1000-1565(2021)05-0599-13A review of proof of data possession in cloud storage environmentTIAN Junfeng, SONG Qianqian, WANG Haoning( School of Cyberspace Security and Computer, Hebei University, Baoding 071002, China )Abstract: With the development of network storage technology, more and more users choose to store data in the cloud, thus users lose direct control of the data. How to verify the integrity of the data stored in the cloud becomes one of the most concerned issue. Proof of Data Possession(PDP)mechanism is considered to be an important means to solve this problem in academia and industry. This paper discusses- 收稿日期:2021-04-28 基金项目:河北省自然科学基金重点项目(F2016201244) 第一作者:田俊峰(1965—),男,河北蠡县人,河北大学教授,博士生导师,主要从事可信计算和信息安全方向研究.E-mail:tjf@hbu.cn 通信作者:宋倩倩(1996—),女,河北邯郸人,河北大学在读硕士研究生,主要从事信息安全方向研究.E-mail:songqianhbu@163.com第5期田俊峰等:云存储环境下数据持有性证明研究综述some of the existing major PDP schemes. Firstly, this paper describes the data possession attestation system model and audit framework, analyzes the functional characteristics and security requirements of the data possession attestation system. Secondly, from the three different perspectives of implementation principles, application scenarios and different entities, the current main data ownership certification schemes have been carried out. Finally, this paper introduces the future research trends in this field.
    Analysis of spike and LFP phase-locking distribution in rhesus monkeys with reach-grasp movement
    LIU Xiuling, GUO Tianxiang, WANG Jie, SUN Hongji, XIONG Peng
    2021, 41(5):  612-622.  DOI: 10.3969/j.issn.1000-1565.2021.05.018
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    The phase-locking relationship between spike firing and local field potential(LFP)is an important neural coding information. However, the analysis of phase-locking distribution characteristics during continuous motion is still lacking.In this study, we used the phase-locking characteristics of spike and LFP delta rhythm in macaques with single-hand reach-to-grasping paradigm to analyze the phase-locking phase distribution in M1, S1 and PPC brain regions at different movement stages, at 100 ms before and after different events, and at continuous time bins.It was found that the phase-locking distribution of Spike and LFP had different phase distribution characteristics and peak position during different stages of continuous movement.In this paper, we analyzed the phase-locking phase distribution in the time bin of 100 ms before and after the occurrence of the key events TargetOn, CenterRelease and TargetHit. The results showed that the phase-locking distribution in the time bin of 100 ms before and after the occurrence of the event was significantly different, and the peak location of phase-locking increased with time.The continuous time bin was used to analyze the phase-locking phase distribution in motion, and the results showed that the phase-locking phase distribution changed with time, and this change became more dramatic before and after the CenterRelease event. Analysis of the mean difference of adjacent time bins showed that the phase-locking phase distribution changed most dramatically in the reaching stage.The regularity of the phase distribution of phase locking at different periods of time in continuous motion can provide a new way to interpret the neural information encoding in the process of motion.
    Ancient Chinese character image retrieval based on space and channel attention fusion network
    TIAN Xuedong, YANG Qiong, YANG Fang
    2021, 41(5):  623-632.  DOI: 10.3969/j.issn.1000-1565.2021.05.019
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    The image retrieval of ancient Chinese characters is an effective auxiliary tool for the research- DOI:10.3969/j.issn.1000-1565.2021.05.019融合空间及通道注意网络的古籍汉字图像检索田学东1,2,杨琼1,2,杨芳1,2(1. 河北大学 网络空间安全与计算机学院,河北 保定 071002;2. 河北大学 智能图文信息处理研究所,河北 保定 071002)田学东 河北大学教授,博士生导师,中国中文信息学会理事,中国计算机学会高级会员,河北省人工智能学会理事.主要从事文字识别、数学信息检索、中文信息处理等方面的研究工作和计算机专业的教学工作.主持国家自然科学基金项目2项,河北省自然科学基金项目4项,其他省部级项目4项.获河北省科技进步三等奖3项,河北省教育厅高校科技成果一等奖1项,授权国家发明专利2项,发表论文30余篇.主要讲授电路分析基础、电子线路基础、数字电路与逻辑设计、软件工程、微机原理与汇编语言等本科课程和模式识别、文字识别工程、计算语言学等研究生课程.摘 要:古籍汉字图像检索是古籍汉字研究的有效工具.然而,古籍汉字字形复杂、书写风格多变的特点导致传统文字图像检索技术在应用于古籍汉字图像时效果欠佳.针对现有方法在古籍汉字图像特征提取时存在的字形结构细节信息和低层视觉特征提取问题,设计了一种融合空间注意力和通道注意力网络高低层特征的古籍汉字图像检索模型.首先,融合空间注意力的低维特征和通道注意力的高维特征,捕捉古籍汉字空间结构间的依赖关系,提取更丰富的古籍汉字语义特征信息;其次,构建inception残差结构模块,丰富古籍汉字图像特征的感受野,使网络模型更易优化,保留足够的古籍汉字细节信息;最后,运用加权交叉熵损失函数,解决数据集中存在的正负样本不平衡问题,增强检索模型的鲁棒性.在上下、左右、包围和独体结构古籍汉字图像数据集上检索实验的MAP(mean average precision)值分别为77.89%、79.89%、78.21%、80.75%,表明了方法的有效性.关键词:古籍汉字;图像检索;空间注意力;通道注意力;加权交叉熵 中图分类号:TP391.43 文献标志码:A 文章编号:1000-1565(2021)05-0623-10Ancient Chinese character image retrieval based on space and channel attention fusion networkTIAN Xuedong1,2, YANG Qiong1,2, YANG Fang1,2(1. School of Cyber Security and Computer, Hebei University, Baoding 071002, China;2.Institute of Intelligent Image and Document Information Processing,Hebei University,Baoding 071002,China)Abstract: The image retrieval of ancient Chinese characters is an effective auxiliary tool for the research- 收稿日期:2021-05-07 基金项目:河北省自然科学基金资助项目(F2019201329) 第一作者:田学东(1963—),男,天津人,河北大学教授,博士生导师,主要从事信息检索、模式识别方向研究. E-mail:xuedong_tian@126.com第5期田学东等:融合空间及通道注意网络的古籍汉字图像检索of ancient Chinese characters. However, the complex shape of ancient Chinese characters and the variety of writing styles have led to poor performance of traditional text image retrieval techniques when applied to ancient Chinese character images. Aiming at the problems in extracting the detailed information of the glyph structure and the low-level visual features in the extraction of the image features of ancient Chinese characters in the existing methods, an ancient Chinese character image retrieval model is designed that combines the high and low-level features of the spatial attention and channel attention network. Firstly, this model integrates the low-dimensional features of spatial attention and the high-dimensional features of channel attention, capture the dependence of the spatial structure of ancient Chinese characters, and extract richer semantic feature information of ancient Chinese characters. Secondly, this model constructs the inception residual structure module to enrich the receptive field of the image features of ancient Chinese characters, make the network model easier to optimize, and retains enough detailed information of the ancient Chinese characters. Finally, the weighted cross-entropy loss function is used to solve the imbalance positive and negative samples in the data set and enhance the robustness of the retrieval model. The MAP values of the retrieval experiment on the ancient Chinese character image data sets with up and down, left and right, enclosing and single-body structures are 77.89%, 79.89%, 78.21%, and 80.75%, respectively, indicating the effectiveness of the method.