光动力抗菌治疗骨髓炎的研究进展

doi:10.3969/j.issn.1000-1565.2022.02.014

摘要/Abstract

摘要： 骨髓炎是由细菌感染引起的深部组织感染性炎症,持续感染会导致骨组织的溶解和坏死. 目前,手术治疗及抗生素治疗很难彻底治愈骨髓炎,且长期使用抗生素还会使细菌产生耐药性,从而增加了骨髓炎的治疗难度. 光动力抗菌化学疗法(photodynamic antimicrobial chemotherapy,PACT)是一种抗感染治疗的新方法,对耐药菌引起的感染具有很好的疗效. 本文介绍了骨髓炎难治的原因和PACT在治疗骨髓炎方面的优势及近期的研究进展. 随着光动力治疗骨髓炎的深入研究,PACT有望成为彻底治愈骨髓炎的新方法.

关键词: 光动力抗菌化学疗法(PACT), 骨髓炎, 光敏剂, 多重耐药菌

Abstract: Osteomyelitis is an infectious inflammation of deep tissues caused by bacterial infection. Persistent infection will lead to dissolution and necrosis of bone tissues. At present, it is difficult to cure osteomyelitis completely by surgical treatment and antibiotic treatment, and long-term use of antibiotics will make bacteria resistant, which makes it more difficult to treat osteomyelitis. Photodynamic antibacterial chemotherapy(PACT)is a new method of anti-infection treatment. Infection caused by drug-resistant bacteria has a good curative effect. This paper introduces the causes of refractory osteomyelitis, the advantages of PACT in the treatment of osteomyelitis and the recent experimental research progress. With the in-depth study of PACT for osteomyelitis, PACT is expected to become a new method to completely cure osteomyelitis.

Key words: photodynamic antibacterial chemotherapy(PACT), osteomyelitis, photosensitizer, multi-drug resistant bacteria

中图分类号:

赵建喜,尹秀娟,方子源,杜梓硕,朱林,赵占娟. 光动力抗菌治疗骨髓炎的研究进展[J]. 河北大学学报(自然科学版), 2022, 42(2): 199-207.

ZHAO Jianxi, YIN Xiujuan, FANG Ziyuan, DU Zishuo, ZHU Lin, ZHAO Zhanjuan. Research progress of photodynamic therapy for osteomyelitis[J]. Journal of Hebei University(Natural Science Edition), 2022, 42(2): 199-207.

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