Preparation of repaglinide hydrogel and evaluation of its transdermal release of drug in vitro and in vivo

doi:10.3969/j.issn.1000-1565.2022.02.008

Abstract

Abstract: The repaglinide hydrogel was prepared by repaglinide-arginine complex. The drug release from hydrogel through isolated skin of mice was investigated by using Franz diffusion cell in vitro. The drug release of hydrogel followed to the zero-order equation. The plasma concentration in rabbits was determined by HPLC. The pharmacokinetic data showed that the time to peak of plasma concentration in the electroporation group was shortened by 2 h, and the amount of drug through percutaneous penetration was 1.8 times of that in the normal group. Compared with repaglinide hydrogel coated with skin directly, rabbit skin using electroporation treatment and then coated with equal dose of drug hydrogel can promote the transdermal penetration of drugs. In addition, the drug release of repaglinide hydrogel showed a good correlation in vitro and in vivo.

Key words: repaglinide, hydrogel, electroporation, percutaneous absorption

CLC Number:

R917

MA Lilan, XU Na, WU Tong, LI Haiying, YANG Wenzhi. Preparation of repaglinide hydrogel and evaluation of its transdermal release of drug in vitro and in vivo[J]. Journal of Hebei University(Natural Science Edition), 2022, 42(2): 158-163.

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