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    25 March 2022, Volume 42 Issue 2
    Estimation of mean life for random truncated data under ranked set sampling
    ZHANG Liangyong, DONG Xiaofang
    2022, 42(2):  113-117.  DOI: 10.3969/j.issn.1000-1565.2022.02.001
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    In order to improve the estimation efficiency of mean life for random truncated data, a nonparametric estimator based on ranked set sampling is proposed by adopting the idea of average rank. Its asymptotic normality is proved, and its asymptotic variance is identified. According to compare the new estimator with the corresponding estimator under simple random sampling, ranked set sampling is shown to be more efficient than simple random sampling. Finally, the application results of practical data verify the correctness of the theoretical results.
    Korovkin approximation theorem on fuzzy continuous functions of several variables
    CHEN Yingwei, CHANG Zhikui, WANG Zhijun
    2022, 42(2):  118-123.  DOI: 10.3969/j.issn.1000-1565.2022.02.002
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    We prove the trigonometric Korovkin approximation theorem for fuzzy valued functions of several variables and verify the approximation via the fuzzy modulus of continuity. Some applications concerning Fejér operators of fuzzy valued functions are also given.
    A new threshold segmentation method for cotton root images
    SHE Lixuan, KANG Jia, WANG Nan, SHAO Limin
    2022, 42(2):  124-130.  DOI: 10.3969/j.issn.1000-1565.2022.02.003
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    In order to detect the cotton root in situ, an automatic global threshold segmentation method was proposed for cotton root image segmentation. Digital device imaging method was used to collect the cotton in-situ root system images, and the automatic global threshold method was used to segment the images. Firstly, the acquired root images are spatially transformed, and the acquired root images are segmented in HSV space. Then, the global threshold segmentation method is used to select the threshold value to binarize the image, and the closed operation method is used to denoise the binary image. Finally, all the noises in the image were filtered through the shape feature screening, and the slender root features in the image are selected. This algorithm can effectively suppress the influence of noise and soil impurities, and can accurately segment the root system. It is an effective method for fast detection of crop root images.
    Effect of coarse aggregate of non-spontaneous combustion coal gangue on mechanical properties of concrete
    NIU Xiaoyan, GAO Qixiang, LI Shenzhen, WANG Guixiang, ZHAO Hui
    2022, 42(2):  131-138.  DOI: 10.3969/j.issn.1000-1565.2022.02.004
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    Non-spontaneous combustion coal gangue is a solid waste produced in the process of coal excavation and sorting. In order to reduce environmental pollution and resource waste caused by the accumulation of non-spontaneous combustion coal gangue and reducing the overuse of natural sand resources. In this work, the physical and chemical properties and the basic mechanical properties of non-spontaneous combustion coal gangue concrete under different coarse aggregate replacement rate, water-cement ratio, additional water consumption and aggregate gradation were studied. The results show that the bulk density and apparent density of non-spontaneous combustion coal gangue are smaller, water absorption is higher and crushing value is larger than that of ordinary gravel. The water-cement ratio and the replacement rate have significant effects on the slump of non-spontaneous combustion coal gangue concrete. The compressive strength, tensile strength and elastic modulus of concrete decrease gradually with the increase of non-spontaneous combustion coal gangue replacement rate and water-cement ratio. When the replacement rate is more than 50%, the above indexes decrease obviously. The additional water consumption and aggregate grade have a certain effect on the non-spontaneous combustion coal gangue concrete. - DOI:10.3969/j.issn.1000-1565.2022.02.004非自燃煤矸石粗骨料对混凝土力学性能的影响牛晓燕1,高琦翔1,李深圳1,王桂香1,赵晖2(1.河北大学 建筑工程学院,河北 保定 071002;2.太原理工大学 土木工程学院,山西 太原 030024)摘 要:非自燃煤矸石是煤炭开挖和分选等过程中产生的固体废弃物,为减少大量非自燃煤矸石堆积而造成的环境污染、资源浪费以及对天然砂石资源的过度利用,研究非自燃煤矸石的理化性能以及在不同粗骨料取代率、水灰比、附加用水量和骨料级配下的非自燃煤矸石混凝土基本力学性能.结果表明:与普通碎石相比,非自燃煤矸石的堆积密度与表观密度小、吸水率高、压碎值大.水灰比和非自燃煤矸石取代率对非自燃煤矸石混凝土坍落度的影响较为明显,随着非自燃煤矸石取代率和水灰比的增大,混凝土的抗压强度、抗拉强度和弹性模量总体上逐渐减小,当取代率超过50%时,以上指标减小较为明显.附加用水量和骨料级配对非自燃煤矸石混凝土力学性能有一定的影响,饱和面干状态下的非自燃煤矸石粗骨料可以有效提高混凝土的抗压强度和弹性模量,但对抗拉强度不利.建议实际工程中非自燃煤矸石取代率小于50%,且当非自燃煤矸石取代率为50%、水灰质量比为0.35时,混凝土强度可以满足C40的设计要求.关键词:非自燃煤矸石;物理性能;配合比;力学性能中图分类号:TU528 文献标志码:A 文章编号:1000-1565(2022)02-0131-08Effect of coarse aggregate of non-spontaneous combustion coal gangue on mechanical properties of concreteNIU Xiaoyan1, GAO Qixiang1, LI Shenzhen1, WANG Guixiang1, ZHAO Hui2(1.College of Civil Engineering and Architecture, Hebei University, Baoding 071002, China; 2. College of Civil Engineering, Taiyuan University of Technology, Taiyuan 030024, China)Abstract: Non-spontaneous combustion coal gangue is a solid waste produced in the process of coal excavation and sorting. In order to reduce environmental pollution and resource waste caused by the accumulation of non-spontaneous combustion coal gangue and reducing the overuse of natural sand resources. In this work, the physical and chemical properties and the basic mechanical properties of non-spontaneous combustion coal gangue concrete under different coarse aggregate replacement rate, water-cement ratio, additional water consumption and aggregate gradation were studied. The results show that the bulk density and apparent density of non-spontaneous combustion coal gangue are smaller, water absorption is higher and crushing value is larger than that of ordinary gravel. The water-cement ratio and the replacement rate have significant effects on the slump of non-spontaneous combustion coal gangue concrete. The compressive strength, tensile strength and elastic modulus of concrete decrease gradually with the increase of non-spontaneous combustion coal gangue replacement rate and water-cement ratio. When the replacement rate is more than 50%, the above indexes decrease obviously. The additional water consumption and aggregate grade have a certain effect on the non-spontaneous combustion coal gangue concrete. - 收稿日期:2021-08-21 基金项目:河北省自然科学基金资助项目(A2019201338) 第一作者:牛晓燕(1979—),女,河北沙河人,河北大学教授,博士,主要从事工程材料理论与应用领域研究.E-mail:niu-xiaoyan2002@163.com 通信作者:王桂香(1965—),女,河北保定人,河北大学副教授,主要从事机械结构设计研究. E-mail:wgxzg@sina.com第2期牛晓燕等:非自燃煤矸石粗骨料对混凝土力学性能的影响The non-spontaneous combustion coal gangue coarse aggregate in the dry state of saturated surface can effectively improve the compressive strength and elastic modulus of concrete, but the tensile strength is disadvantage. It is suggested that the replacement rate of non-spontaneous combustion coal gangue is less than 50% in actual engineering, and when the replacement rate is 50% and the water-cement ratio is 0.35, the concrete strength can meet the design requirements of C40.
    Vacuum stability of Higgs potential in the minimum supersymmetric model
    YAN Ben, FENG Taifu
    2022, 42(2):  139-143.  DOI: 10.3969/j.issn.1000-1565.2022.02.005
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    The one loop correction to the Higgs effective potential and the improvement of renormalization group equation in quantum field theory are discussed. These processing method is applied to the minimum supersymmetric model(MSSM). In the framework of MSSM, the limitation of a stable Higgs effective potential on the sensitive parameter tan β is discussed. Using the two loop order numerical solution for the renormalization group equation, the vacuum stability of the Higgs potential is studied under different energy scales. The results show that the behavior of the Higgs potential changes with the increase of the energy scale, but there is no instability as that in the standard model.
    Pattern of hexagon with line in dielectric barrier discharge
    WANG Yue, PAN Yuyang, LI Yaohua, LI Caixia, ZHAO Wei,FU Shaoduo
    2022, 42(2):  144-149.  DOI: 10.3969/j.issn.1000-1565.2022.02.006
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    Pattern of hexagon with line has been found for the first time in dielectric barrier discharge system. An intensified charge-coupled device camera and photomultiplier tubes were used to investigate the spatiotemporal structure and temporal correlation of the luminescent pattern. It is found that the luminescent pattern is composed of three sets of substructures: the center point in the hexagon, the point on the hexagon;the line between two points of the hexagon and the halo of the hexagon. Lets call them C(center), V(vertex)+L(line), H(halo). All of their discharges occur at the rising edge of the voltage. The optical signals at V and L were measured by two photomultiplier tubes simultaneously.It is found that both of their discharge in the second current pulse are random. Photos with exposure time of 50 μs were taken by high speed video camera, the results show that L is composed of random filaments. The wall charge theory- DOI:10.3969/j.issn.1000-1565.2022.02.006介质阻挡放电中带线六边形斑图王玥1,潘宇扬2,李耀华1,李彩霞3,赵薇2,付少铎2(1.河北大学 物理科学与技术学院,河北 保定 071002;2.河北大学 质量技术监督学院, 河北 保定 071002;3.河北大学 电子信息工程学院,河北 保定 071002)摘 要:在介质阻挡放电系统中首次发现了带线六边形斑图.利用高速照相机和光电倍增管对斑图的时空结构和时间相关性进行测量,发现该斑图是由带线六边形内的中心点、带线六边形上的点及线和带线六边形内晕3套子结构组成,分别将其记作C(center),V(vertex)+L(line),H(halo),放电全部发生在电压上升沿.利用2个光电倍增管同时对V、L处进行测量,发现二者都在第2个电流脉冲放电且放电顺序随机.利用高速录像机拍摄曝光时间为50 μs放电照片,发现L是由随机放电丝组成.利用壁电荷理论解释带线六边形斑图的时空结构及形成机制.关键词:斑图;介质阻挡放电;六边形结构;壁电荷 中图分类号:O43 文献标志码:A 文章编号:1000-1565(2022)02-0144-06Pattern of hexagon with line in dielectric barrier dischargeWANG Yue1, PAN Yuyang2, LI Yaohua1, LI Caixia3, ZHAO Wei2,FU Shaoduo2(1. College of Physics Science and Technology, Hebei University, Baoding 071002, China;2. College of Quality and Technical Supervision, Hebei University, Baoding 071002, China;3.College of Electronic Information Engineering, Hebei University, Baoding 071002, China)Abstract: Pattern of hexagon with line has been found for the first time in dielectric barrier discharge system. An intensified charge-coupled device camera and photomultiplier tubes were used to investigate the spatiotemporal structure and temporal correlation of the luminescent pattern. It is found that the luminescent pattern is composed of three sets of substructures: the center point in the hexagon, the point on the hexagon;the line between two points of the hexagon and the halo of the hexagon. Lets call them C(center), V(vertex)+L(line), H(halo). All of their discharges occur at the rising edge of the voltage. The optical signals at V and L were measured by two photomultiplier tubes simultaneously.It is found that both of their discharge in the second current pulse are random. Photos with exposure time of 50 μs were taken by high speed video camera, the results show that L is composed of random filaments. The wall charge theory- 收稿日期:2021-03-22 基金项目:国家自然科学基金资助项目(12075075);河北省科技计划项目(A2020201016);河北大学大学生创新项目(2021373) 第一作者:王玥(1997—),女,河北唐山人,河北大学在读硕士研究生,主要从事非线性介质阻挡放电斑图研究. E-mail:478722914@qq.com 通信作者:潘宇扬(1989—),女,河北保定人,河北大学副教授,主要从事光学及测量控制等方面研究.E-mail: Pyy1616@163.com第2期王玥等:介质阻挡放电中带线六边形斑图is used to explain the spatiotemporal structure and the formation mechanism of pattern of hexagon with line.
    Preparation of novel microsphere for hepatic arterial embolism
    SONG Pengjin, HAN Xiao, SUN Caifeng, SUN Haichuan, CAO Xiaoliang, HU Liandong
    2022, 42(2):  150-157.  DOI: 10.3969/j.issn.1000-1565.2022.02.007
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    To develop curcumin loaded microspheres suitable for transcatheter arterial chemoembolization(TACE)and to explore its therapeutic effect on liver cancer, microspheres were prepared with polyvinyl alcohol(PVA)as a carrier material by emulsification cross-linking method. The morphology and particle size distribution of the drug-loaded microspheres were evaluated. The inhibitory effects of microspheres on cancer cells were observed. We used VX2 liver cancer rabbit models to discuss the effectiveness of curcumin-loaded microspheres for hepatic artery embolization. Scanning electron microscope and particle size analysis showed that the microspheres had good sphericity. Safety testing determined that the safety index of microspheres was higher. The pharmacodynamic study showed that curcumin embolic microspheres could effectively play the role of arterial embolization after embolization administration and improve the therapeutic effect of liver cancer. Curcumin embolic microspheres had been successfully prepared in this study, which were expected to be used for embolization to improve the therapeutic efficiency- DOI:10.3969/j.issn.1000-1565.2022.02.007新型肝动脉栓塞微球制剂的制备宋鹏锦1,韩啸1,孙彩凤1,孙海川2,曹晓亮3,胡连栋1(1.河北大学 河北省药物质量分析控制重点实验室,药学院,河北 保定 071002;2.保定市第一中心医院 医务处,河北 保定 071000;3.保定市第一医院 介入医学科,河北 保定 071000)摘 要:开发了一种适合肝动脉灌注化疗栓塞(TACE)用的姜黄素载药微球,并探究其对肝癌的治疗效果.以聚乙烯醇(PVA)为载体,采用乳液交联法制备微球,观察微球的外观和粒度,证明微球对癌细胞的抑制作用,在VX2兔模型中评估肝动脉栓塞微球治疗肝癌的功效.扫描电镜和粒度分析显示制备的微球球形完整;生物安全性证明微球材料安全指数较高;药效学研究表明姜黄素栓塞微球可在栓塞给药后有效发挥动脉栓塞作用,提高肝癌的治疗效果.本研究成功地制备了姜黄素栓塞微球,有望将其用于栓塞以提高TACE在肝癌中的治疗效果.关键词:肝细胞癌;姜黄素;微球;肝动脉化疗栓塞中图分类号:R944 文献标志码:A 文章编号:1000-1565(2022)02-0150-08Preparation of novel microsphere for hepatic arterial embolismSONG Pengjin1, HAN Xiao1, SUN Caifeng1, SUN Haichuan2, CAO Xiaoliang3, HU Liandong1(1. College of Pharmacy, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China; 2. Medical Affair Department, Baoding First Central Hospital, Baoding 071000, China;3. Intervention Therapy Department, Baoding No. 1 Hospital, Baoding 071000, China)Abstract: To develop curcumin loaded microspheres suitable for transcatheter arterial chemoembolization(TACE)and to explore its therapeutic effect on liver cancer, microspheres were prepared with polyvinyl alcohol(PVA)as a carrier material by emulsification cross-linking method. The morphology and particle size distribution of the drug-loaded microspheres were evaluated. The inhibitory effects of microspheres on cancer cells were observed. We used VX2 liver cancer rabbit models to discuss the effectiveness of curcumin-loaded microspheres for hepatic artery embolization. Scanning electron microscope and particle size analysis showed that the microspheres had good sphericity. Safety testing determined that the safety index of microspheres was higher. The pharmacodynamic study showed that curcumin embolic microspheres could effectively play the role of arterial embolization after embolization administration and improve the therapeutic effect of liver cancer. Curcumin embolic microspheres had been successfully prepared in this study, which were expected to be used for embolization to improve the therapeutic efficiency- 收稿日期:2021-06-20 基金项目:河北省重点研发计划(19272701D);河北省自然科学基金资助项目(H2020201036);河北省研究生创新资助项目(CXZZSS2020002);河北省创新能力提升计划(20567605H) 第一作者:宋鹏锦(1998—),女,河北邢台人,河北大学在读硕士研究生.E-mail: 1943006472@qq.com 通信作者:胡连栋(1978—),男,河北石家庄人,河北大学教授,博士,主要从事药物新制剂研究.E-mail:hbupharm@126.com第2期宋鹏锦等:新型肝动脉栓塞微球制剂的制备of TACE in liver cancer.
    Preparation of repaglinide hydrogel and evaluation of its transdermal release of drug in vitro and in vivo
    MA Lilan, XU Na, WU Tong, LI Haiying, YANG Wenzhi
    2022, 42(2):  158-163.  DOI: 10.3969/j.issn.1000-1565.2022.02.008
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    The repaglinide hydrogel was prepared by repaglinide-arginine complex. The drug release from hydrogel through isolated skin of mice was investigated by using Franz diffusion cell in vitro. The drug release of hydrogel followed to the zero-order equation. The plasma concentration in rabbits was determined by HPLC. The pharmacokinetic data showed that the time to peak of plasma concentration in the electroporation group was shortened by 2 h, and the amount of drug through percutaneous penetration was 1.8 times of that in the normal group. Compared with repaglinide hydrogel coated with skin directly, rabbit skin using electroporation treatment and then coated with equal dose of drug hydrogel can promote the transdermal penetration of drugs. In addition, the drug release of repaglinide hydrogel showed a good correlation in vitro and in vivo.
    Chidamide induces apoptosis of colon cancer HCT-15 cells through mitochondrial apoptosis pathway
    ZHAO Linshan, LI Yumiao, LI Nan, JIA Youchao, WANG Xiaofang, HAN Qiang, ZANG Aimin
    2022, 42(2):  164-170.  DOI: 10.3969/j.issn.1000-1565.2022.02.009
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    The inhibitory effect and mechanism of Chidamide on the proliferation of colon cancer cell line HCT-15 were studied. HCT-15 were treated with different concentrations of Chidamide, and cell proliferation and drug sensitivity were detected by CCK-8 method; The ability of cell clone formation in vitro was detected by plate clone formation assay. Apoptosis was detected by flow cytometry. The cell cycle was detected by EdU experiment, the expression level of acetylated histone, mitochondrial apoptosis-related proteins, and cell cycle-related proteins were detected by Western blot. The results show that Chidamide inhibited the proliferation of HCT-15 cells in a concentration and time-dependent manner, weakened the ability- DOI:10.3969/j.issn.1000-1565.2022.02.009西达本胺通过线粒体凋亡途径诱导结肠癌HCT-15细胞凋亡赵琳珊1,2,李玉苗1,李楠1,贾友超1,王晓芳1,韩强1,臧爱民1(1.河北大学附属医院 肿瘤内科,河北省肿瘤放化疗机制与规程研究重点实验室,河北 保定 071000;2.河北大学 临床医学院,河北 保定 071000)摘 要:研究西达本胺(Chidamide)对结肠癌细胞系HCT-15的增殖抑制作用及机制. 以不同浓度西达本胺处理HCT-15细胞,CCK-8法检测细胞增殖情况及细胞的药物敏感性;平板克隆形成实验检测细胞体外克隆形成能力;流式细胞术检测细胞凋亡;EdU实验检测细胞增殖周期;Western blot检测乙酰化组蛋白、线粒体凋亡途径相关蛋白、细胞周期相关蛋白表达水平的变化. 结果表明:西达本胺抑制HCT-15细胞增殖呈浓度和时间依赖性,细胞体外克隆形成能力减弱,凋亡增多,细胞分裂相明显减少、总周期变慢,乙酰化组蛋白H3和H4、线粒体介导的相关凋亡蛋白表达上调、p21、p27表达上调、CDK2、CyclinA2蛋白表达下调. 西达本胺可抑制HCT-15细胞增殖,通过线粒体途径诱导细胞凋亡并阻滞细胞周期. 关键词:西达本胺;结肠癌;乙酰化;线粒体凋亡途径中图分类号:R917 文献标志码:A 文章编号:1000-1565(2022)02-0164-07Chidamide induces apoptosis of colon cancer HCT-15 cells through mitochondrial apoptosis pathwayZHAO Linshan1,2, LI Yumiao1, LI Nan1, JIA Youchao1, WANG Xiaofang1, HAN Qiang1, ZANG Aimin1(1. Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Department of Medical Oncology, Affiliated Hospital of Hebei University, Baoding 071000, China; 2. Clinical Medical College, Hebei University, Baoding 071000, China )Abstract: The inhibitory effect and mechanism of Chidamide on the proliferation of colon cancer cell line HCT-15 were studied. HCT-15 were treated with different concentrations of Chidamide, and cell proliferation and drug sensitivity were detected by CCK-8 method; The ability of cell clone formation in vitro was detected by plate clone formation assay. Apoptosis was detected by flow cytometry. The cell cycle was detected by EdU experiment, the expression level of acetylated histone, mitochondrial apoptosis-related proteins, and cell cycle-related proteins were detected by Western blot. The results show that Chidamide inhibited the proliferation of HCT-15 cells in a concentration and time-dependent manner, weakened the ability- 收稿日期:2021-11-19 基金项目:河北省政府资助临床医学优秀人才课题(361007);河北大学医学学科培育项目(2021B15) 第一作者:赵琳珊(1995—),女,河南安阳人,河北大学在读硕士研究生,主要从事肿瘤药理学研究. E-mail:13502155703@163.com 通信作者:臧爱民(1962—),女,河北保定人,河北大学附属医院教授,主要从事肿瘤生物学治疗方向研究. E-mail:booszam@sina.com韩强(1968—),女,河北保定人,河北大学附属医院主任医师,主要从事肿瘤生物学治疗方向研究. E-mail:hanqiang68716@alliyun.com第2期赵琳珊等:西达本胺通过线粒体凋亡途径诱导结肠癌HCT-15细胞凋亡of cell cloning in vitro, increased apoptosis, significantly reduced the image of cell division, and slowed down the total cycle. The results of western blot showed that acetylated histones H3, H4, mitochondria-mediated apoptosis-related proteins, p21, and p27 were up-regulated. Meanwhile, CDK2 and cyclin A2 were down-regulated. Chidamide could inhibit proliferation, induce apoptosis and block the cell cycle of HCT-15 cells.
    Determination of trace copper in water by alizarin red “switch” fluorescent probe
    LYU Yajuan, SHI Xinrong, LI Zhiying
    2022, 42(2):  171-176.  DOI: 10.3969/j.issn.1000-1565.2022.02.010
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    A complex emitting orange yellow fluorescence were generated by the mixture of the alizarin red and excessive Al3+ at pH = 5.2. The maximum fluorescence excitation and emission wavelength of the colored complex were located at 469 nm and at 585 nm, respectively, The fluorescence intensity of the alizarin red-Al3+ system could be quenched by a certain amount of Cu2+,and the fluorescence quenching value showed a linear relationship with the concentration of Cu2+ within limits, thus establishing a sensitive and switching method for the determination of Cu2+. The optimal factors of the determination system were investigated,such as the dosage ratio, reaction temperature, reaction time,pH and buffer solution. The results showed that the standard working curve was ΔF=19.7c+101.21(R2=0.999 5), the linear range was 0.2~30 μmol/L, and the detection limit was 0.022 μmol/L. The method shows high accuracy, high sensitivity, good selectivity, and could be used for the detection of trace copper ion in water.
    Description of one new species of the subgenus Euryhelops Reitter, 1902 from China(Coleoptera: Tenebrionidae: Platyscelidini)
    REN Guodong, NIU Yiping, BAI Xinglong
    2022, 42(2):  177-181.  DOI: 10.3969/j.issn.1000-1565.2022.02.011
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    One new species of the subgenus Euryhelops from China(Henan, Shanxi), Bioramix(Euryhelops)funiushanensis sp. nov. is described in this paper, characters and habitus are figured. B. funiushanensis sp. nov. is similar to B. globipunctata L. Bai & Ren, 2016, it differs from the later by:1)anterior margin of gena paralleled anterior to eyes; 2)pronotal surface without metallic sheen, punctures merging into longitudinal wrinkles partially at sides; 3)pronotal and elytral surface with tiny yellow setae; 4)distal part of parameres slightly curved dorsally in lateral view. Known Chinese species of the subgenus Euryhelops are listed, distribution characteristics of the subgenus from China is generalized. The materials are deposited at Hebei University Museum.
    Diversity of bird community in spring in Bodhi islands, Hebei province
    YANG Junfeng,LIU Qiqi,ZHANG Kan,LIN Qingqian,HOU Jianhua
    2022, 42(2):  182-189.  DOI: 10.3969/j.issn.1000-1565.2022.02.012
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    In order to grasp the dynamic changes of birds in Bodhi islands in spring,the line method and point method were used to investigate the bird situation in the islands from February to May, 2021, and the results showed that:1)A total of 146 species belonging to 40 families and 16 orders were recorded, among which 84 species were migratory birds, 28 resident birds, 24 summer migrants and 10 winter migrants birds.2)The dominant species of Dunlin(Calidris alpina)and Black-bellied Plover(Pluvialis squatarola), 13 common species, 20 rare species and 111 rare species;3)There were 4 species of birds under the first class state protection and 19 species under the second class state protection;4)Bird abundance and species richness peaked in April.Shannon-Wiener index(H')was the highest in May, and Pielou evenness index(J)was the highest in February.The Sørensen similarity coefficient(Si)of bird community was the highest in March and April, and the lowest in May and February.5)In different habitats,H' was the highest in woodland and the lowest in dune.The J was the highest in grassland, and the lowest in residential area and dune. The(Si)of bird community between grassland and reed wetland is the highest,and the(Si)in the intertidal beach and dune is the lowest.The results show that the Bodhi islands are rich in bird resources in spring, with a large number of rare and endangered birds, and are a resting- DOI:10.3969/j.issn.1000-1565.2022.02.012河北菩提岛诸岛春季鸟类群落多样性杨俊锋,刘琪琪,张侃,林庆乾,侯建华(河北大学 生命科学学院,河北 保定 071002)摘 要:为掌握菩提岛诸岛春季鸟类的动态变化,2021年2月至5月运用样线法和样点法对该岛鸟类情况进行了调查,结果发现:1)共记录鸟类146种,隶属于16目40科,其中旅鸟84种、留鸟28种、夏候鸟24种、冬候鸟10种;2)优势种为黑腹滨鹬(Calidris alpina)和灰鸻(Pluvialis squatarola),常见种13种,稀有种20种,罕见种111种;3)国家一级重点保护鸟类4种,国家二级重点保护鸟类19种;4)鸟类多度和物种丰富度在4月达到峰值.Shannon-Wiener指数(H')5月最高,Pielou均匀度指数(J)2月最高.3月和4月鸟类群落Sørensen相似性系数(Si)最高,5月和2月最低;5)在不同生境中,林地H'最高,沙丘最低.草地J最高,居住区和沙丘最低.草地与芦苇湿地之间的鸟类群落Si最高,潮间带滩涂与沙丘最低.研究结果表明,菩提岛诸岛春季鸟类资源丰富,珍稀濒危鸟类众多,是多种迁徙鸟类的停歇地,应加强保护和监管力度.关键词:菩提岛;春季;鸟类群落;多样性中图分类号:Q958.1 文献标志码:A 文章编号:1000-1565(2022)02-0182-08Diversity of bird community in spring in Bodhi islands, Hebei provinceYANG Junfeng,LIU Qiqi,ZHANG Kan,LIN Qingqian,HOU Jianhua(School of Life Sciences,Hebei University,Baoding 071002,China)Abstract: In order to grasp the dynamic changes of birds in Bodhi islands in spring,the line method and point method were used to investigate the bird situation in the islands from February to May, 2021, and the results showed that:1)A total of 146 species belonging to 40 families and 16 orders were recorded, among which 84 species were migratory birds, 28 resident birds, 24 summer migrants and 10 winter migrants birds.2)The dominant species of Dunlin(Calidris alpina)and Black-bellied Plover(Pluvialis squatarola), 13 common species, 20 rare species and 111 rare species;3)There were 4 species of birds under the first class state protection and 19 species under the second class state protection;4)Bird abundance and species richness peaked in April.Shannon-Wiener index(H')was the highest in May, and Pielou evenness index(J)was the highest in February.The Sørensen similarity coefficient(Si)of bird community was the highest in March and April, and the lowest in May and February.5)In different habitats,H' was the highest in woodland and the lowest in dune.The J was the highest in grassland, and the lowest in residential area and dune. The(Si)of bird community between grassland and reed wetland is the highest,and the(Si)in the intertidal beach and dune is the lowest.The results show that the Bodhi islands are rich in bird resources in spring, with a large number of rare and endangered birds, and are a resting- 收稿日期:2021-08-23 基金项目:国家林业局全国第二次陆生野生动物资源调查项目(2017—2018);河北大学自然科学研究计划项目(2014-299) 第一作者:杨俊锋(1996—),男,四川广安人,河北大学在读硕士研究生,主要从事动物学研究.E-mail:2523292527@qq.com 通信作者:侯建华(1968—),男,河北保定人,河北大学教授,博士,博士生导师,主要从事动物生态学研究.E-mail:13633325718@163.com第2期杨俊锋等:河北菩提岛诸岛春季鸟类群落多样性place for many kinds of migratory birds, so protection and supervision should be strengthened.
    Temporal distribution of metazoan zooplankton functional groups and environmental driving factors in Beidaihe national wetland park
    ZHOU Jing,XIAO Guohua,WU Dayong,WANG Junxia,LIU Cunqi
    2022, 42(2):  190-198.  DOI: 10.3969/j.issn.1000-1565.2022.02.013
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    The investigation of metazoan zooplankton and water environment were operated from April 2019 to November 2019 in Beidaihe national wetland park, in order to analyze the temporal distribution of metazoan zooplankton functional groups and environmental driving factors. The results showed that a total of 95 species of metazoan zooplankton were identified. According to the size and feeding habits, 8 functional groups of metazoan zooplankton were identified. The functional groups are consisted with that small size metazoan zooplankton were dominant in the whole year in density and biomass. There were significant differences in the functional groups of metazoan zooplankton between spring and the other three seasons by analysis of similarities(ANOSIM)and non-metric multidimensional scaling(NMDS)in coastal freshwater wetland. The results showed that the driving factors of distribution of metazoan zooplankton functional groups had seasonal differences by the Mantel test, redundancy analysis(RDA)and partial least- DOI:10.3969/j.issn.1000-1565.2022.02.013北戴河国家湿地公园后生浮游动物功能群季节分布及影响因子周静1,肖国华2,武大勇3,王军霞1,刘存歧1(1.河北大学 生命科学学院,河北 保定 071002;2.河北省海洋生物资源与环境重点实验室,河北 秦皇岛 066200;3.衡水学院 河北省湿地生态与保护重点实验室,河北 衡水 053000)摘 要:2019年4月至11月在北戴河国家湿地公园进行后生浮游动物和水环境调查,以探究滨海淡水湿地后生浮游动物功能群的季节分布特征及影响因子.采用相似性分析(analysis of similarities,ANOSIM)、非度量多维尺度分析(non-metric multidimensional scaling,NMDS)、Mantel检验、冗余分析(redundancy analysis,RDA)及偏最小二乘路径模型(partial least squares-path modeling,Pls-pm)对后生浮游动物功能群和影响因子进行研究,调查期间共采集并鉴定后生浮游动物95种,共划分为8个功能群.结果显示,研究地后生浮游动物功能群组成春季与夏、秋、冬3季差异显著;小型个体组成的功能群在全年密度和生物量中均占优势;非营养盐类环境因子为后生浮游动物功能群季节演替主要驱动因子;营养盐类环境因子对后生浮游动物功能群季节演替影响较小.关键词:滨海淡水湿地;后生浮游动物;功能群;季节演替;驱动因子中图分类号:Q145 文献标志码:A 文章编号:1000-1565(2022)02-0190-09Temporal distribution of metazoan zooplankton functional groups and environmental driving factors in Beidaihe national wetland parkZHOU Jing1,XIAO Guohua2,WU Dayong3,WANG Junxia1,LIU Cunqi1(1. School of Life Sciences, Hebei University, Baoding 071002, China; 2. Hebei Key Laboratory of Marine Biological Resources and Environment, Qinhuangdao 066200, China; 3. Hebei Key Laboratory of Wetland Ecology and Conservation, Hengshui University, Hengshui 053000, China)Abstract: The investigation of metazoan zooplankton and water environment were operated from April 2019 to November 2019 in Beidaihe national wetland park, in order to analyze the temporal distribution of metazoan zooplankton functional groups and environmental driving factors. The results showed that a total of 95 species of metazoan zooplankton were identified. According to the size and feeding habits, 8 functional groups of metazoan zooplankton were identified. The functional groups are consisted with that small size metazoan zooplankton were dominant in the whole year in density and biomass. There were significant differences in the functional groups of metazoan zooplankton between spring and the other three seasons by analysis of similarities(ANOSIM)and non-metric multidimensional scaling(NMDS)in coastal freshwater wetland. The results showed that the driving factors of distribution of metazoan zooplankton functional groups had seasonal differences by the Mantel test, redundancy analysis(RDA)and partial least- 收稿日期:2021-10-12 基金项目:生态环境部生物多样性调查评估项目(2019HJ2096001006);河北省重点研发计划项目(20373603D);河北省湿地生态与保护重点实验室开放基金资助项目(hklk202003) 第一作者:周静(1989—),女,天津人,河北大学在读硕士研究生,主要从事水生态研究. E-mail: 280972025@qq.com 通信作者:刘存歧(1967—),男,河北秦皇岛人,河北大学教授,博士,主要从事水生态研究. E-mail: liucunqi@sina.com王军霞(1974—),女,河北新乐人,河北大学副教授,主要从事水生态研究. E-mail: 303370613@qq.com第2期周静等:北戴河国家湿地公园后生浮游动物功能群季节分布及影响因子squares-path modeling(Pls-pm)in coastal freshwater wetland. The physical-chemical factors were the main driving factors for the seasonal succession of metazoan zooplankton functional groups. Nutrients had little effect on the seasonal succession of metazoan zooplankton functional groups.
    Research progress of photodynamic therapy for osteomyelitis
    ZHAO Jianxi, YIN Xiujuan, FANG Ziyuan, DU Zishuo, ZHU Lin, ZHAO Zhanjuan
    2022, 42(2):  199-207.  DOI: 10.3969/j.issn.1000-1565.2022.02.014
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    Osteomyelitis is an infectious inflammation of deep tissues caused by bacterial infection. Persistent infection will lead to dissolution and necrosis of bone tissues. At present, it is difficult to cure osteomyelitis completely by surgical treatment and antibiotic treatment, and long-term use of antibiotics will make bacteria resistant, which makes it more difficult to treat osteomyelitis. Photodynamic antibacterial chemotherapy(PACT)is a new method of anti-infection treatment. Infection caused by drug-resistant bacteria has a good curative effect. This paper introduces the causes of refractory osteomyelitis, the advantages of PACT in the treatment of osteomyelitis and the recent experimental research progress. With the in-depth study of PACT for osteomyelitis, PACT is expected to become a new method to completely cure osteomyelitis.
    Neighbor sample joint learning for malaria parasite recognition
    HA Yan,MENG Xiangjie,TIAN Junfeng
    2022, 42(2):  208-216.  DOI: 10.3969/j.issn.1000-1565.2022.02.015
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    Malaria is a serious and fatal infectious disease and early detection of the patients infection severity can effectively curb the outbreak of this infectious disease. Deep learning has been verified to have excellent capability in image classification and disease diagnosis in many challenging tasks, such as cell detection and histological image classification. There exist many deep learning studies on malaria parasite recognition with successful applications, but they mainly focus on binary classification of single ring stage and red blood cells. The most important disadvantages of them are ignoring other stages of malaria parasites, including Trophozoite, Gametocytes and Schizont. In this paper, we are the first to study the multi-stage malaria parasite recognition problem, and propose a novel Neighbor Sample Joint Learning(NSJL)for this challenging task. Specifically, NSJL consists of CNN(Convolutional Neural Network)feature learning, neighbour correlation mining and graph representation modules. The method firstly extracts CNN representations from each parasite image and then establishes the neighbour correlations among CNN features by K-Nearest Neighbour(K-NN)graph building algorithms, with operating Graph Convolutional Network(GCN)on CNN features and their correlations. To evaluate the performance of our- DOI:10.3969/j.issn.1000-1565.2022.02.015基于近邻样本联合学习模型的疟疾识别算法哈艳1,2,孟翔杰3,田俊峰2,4(1.河北大学 管理学院,河北 保定 071002;2.河北省高可信信息系统重点实验室,河北 保定 071002;3.河北大学 数学与信息科学学院,河北 保定 071002;4.河北大学 网络空间安全与计算机学院,河北 保定 071002)摘 要:疟疾早期诊断可以有效防止疾病暴发.深度学习在细胞形态和组织图像检测等任务中具有出色能力.已有许多基于深度学习的疟疾研究,但它们主要用于环状体和红细胞二分类.本文首次研究疟疾多阶段识别,并提出近邻样本联合学习(neighbor sample joint learning,NSJL)模型.NSJL包括卷积神经网络(convolutional neural network,CNN)特征学习、领域相关性挖掘和图特征嵌入.它提取CNN特征,并将其与K近邻(K-nearset neighbor,K-NN)建立的邻域图传入图卷积网络(graph convolutional network,GCN).为评估NSJL,将其与先进方法比较,结果表明NSJL模型可达92.50%准确率,92.84%精确度,92.50%召回率和92.52%F1分数,至少高于其他方法7%的准确率表明其优秀疟疾识别能力.关键词:疟原虫识别;图卷积网络;多阶段分类;样本联系;深度学习.中图分类号:TP391 文献标志码:A 文章编号:1000-1565(2022)02-0208-09Neighbor sample joint learning for malaria parasite recognitionHA Yan1,2,MENG Xiangjie3,TIAN Junfeng2,4(1. School of Management, Hebei University, Baoding 071002,China;2. Key Laboratory on High Trusted Information System in Hebei Province, Baoding 071002,China; 3. College of Mathematics and Information Science, Hebei University, Baoding 071002,China; 4. School of Cyber Security and Computer, Hebei University, Baoding 071002,China)Abstract: Malaria is a serious and fatal infectious disease and early detection of the patients infection severity can effectively curb the outbreak of this infectious disease. Deep learning has been verified to have excellent capability in image classification and disease diagnosis in many challenging tasks, such as cell detection and histological image classification. There exist many deep learning studies on malaria parasite recognition with successful applications, but they mainly focus on binary classification of single ring stage and red blood cells. The most important disadvantages of them are ignoring other stages of malaria parasites, including Trophozoite, Gametocytes and Schizont. In this paper, we are the first to study the multi-stage malaria parasite recognition problem, and propose a novel Neighbor Sample Joint Learning(NSJL)for this challenging task. Specifically, NSJL consists of CNN(Convolutional Neural Network)feature learning, neighbour correlation mining and graph representation modules. The method firstly extracts CNN representations from each parasite image and then establishes the neighbour correlations among CNN features by K-Nearest Neighbour(K-NN)graph building algorithms, with operating Graph Convolutional Network(GCN)on CNN features and their correlations. To evaluate the performance of our- 收稿日期:2021-05-26 基金项目:国家自然科学基金资助项目(61802106);河北省自然科学基金资助项目(F2021201049) 第一作者:哈艳(1974—),女,回族,河北肃宁人,河北大学教授,河北大学在读博士,主要从事深度学习、可信计算方向研究.E-mail:hayanhbu@163.com第2期哈艳等:基于近邻样本联合学习模型的疟疾识别算法NSJL model, we compare it with several advanced existing methods, and our model can achieve a high accuracy of 92.50%, precision of 92.84%, recall of 92.50% and F1-score of 92.52%. The comparison with existing advanced methods verifies the NSJL model has excellent capability for recognizing multi-stage malaria parasite, which is higher than the compared methods by at least 7% in accuracy.
    A deep siamese network algorithm with template updating for object tracking
    CHEN Liping, YUAN Tongtong, YANG Wenzhu, CHEN Xiangyang, WANG Sile
    2022, 42(2):  217-224.  DOI: 10.3969/j.issn.1000-1565.2022.02.016
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    To solve the problem of inaccurate target location caused by scale variation, occlusion and motion blur during the tracking process, a deep Siamese network target tracking algorithm with high confidence template updating mechanism is proposed based on the SiamFC(fully convolutional siamese network). First, the main network uses ResNet-50 residual network for feature extraction and multi-layer feature maps for target prediction; second, a high confidence template updateing module is constructed to avoid the template drift caused by frequent updating. Experimental results indicate that the success rate and tracking accuracy of the proposed algorithm are increased by about 3.4% and 2.6% respectively compared to the benchmark algorithm when running on the dataset of OTB100. The experiments under various challenging factors show that the proposed algorithm has good robustness, which can resist the effects of various complex factors effectively such as target occlusion, scale variation and motion blur.