Isolation and identification of secondary metabolites of Fusarium equiseti

doi:10.3969/j.issn.1000-1565.2023.05.010

Journal of Hebei University(Natural Science Edition) ›› 2023, Vol. 43 ›› Issue (5): 512-516.DOI: 10.3969/j.issn.1000-1565.2023.05.010

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Isolation and identification of secondary metabolites of Fusarium equiseti

PAN Huayang¹, LIU Huaguang¹, QI Zexin¹, ZHAO Xiaolong^1,2, LUO Duqiang^1,2

1. College of Chemistry and Materials Science, Hebei University, Baoding 071002, China; 2. College of Life Sciences, Hebei University, Baoding 071002, China

Received:2022-10-21 Online:2023-09-25 Published:2023-10-25

Abstract

Abstract: In order to find compounds with new structures and significant pharmacological effects, three compounds 1, 2 and 3 were isolated and identified from the secondary metabolites of the endophytic fungus Fusarium equiseti from Harmonia axyridis by modern isolation methods. Among them, compounds 1(equisetin)and 2(epi-equisetin)are a pair of epiisomers, and 3(6-methoxy-droperylene)belongs to steroids. In vitro protein tyrosine phosphatase 1B(PTP1B)inhibitory activity test showed that compounds 1 and 2 had certain inhibitory activity on PTP1B, and IC₅₀ values were(8.73 ± 0.03),(12.88 ± 0.16)μg/mL. It provides potential drug lead compounds for the development of new PTP1B inhibitors.

Key words: insect endophytic fungi, structure identification, activity test

CLC Number:

Q936

PAN Huayang, LIU Huaguang, QI Zexin, ZHAO Xiaolong, LUO Duqiang. Isolation and identification of secondary metabolites of Fusarium equiseti[J]. Journal of Hebei University(Natural Science Edition), 2023, 43(5): 512-516.

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Isolation and identification of secondary metabolites of Fusarium equiseti

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