Preparation of abiraterone cyclodextrin inclusion complex tablets

doi:10.3969/j.issn.1000-1565.2020.05.007

Abstract

Abstract: To study the best technie of the abiraterone-2- hydroxypropyl-β-cyclodextrin inclusion complex tablets. Orthogonal experiment was used to select of the best preparation technology by using the time limit of the disintegrating of vegetarian tablets as the investigation index. Best preparation of tablets are lactose 15 g, the amount of crosslinked sodium carboxymethylcellulose 1 g, 3%(g/g)binder. This method of preparation of the abiraterone-2-hydroxypropyl-β-cyclodextrin inclusion complex tablets is reasonable and reliable.

Key words: abiraterone, complex tablets, disintegration time limit, solubility, bioavailability

CLC Number:

TANG Huayang,LI Jianheng,XU Feng. Preparation of abiraterone cyclodextrin inclusion complex tablets[J]. Journal of Hebei University (Natural Science Edition), 2020, 40(5): 494-499.

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